Results 11 to 20 of about 17,437 (131)

SnRNA-Seq of Pancreas Revealed the Dysfunction of Endocrine and Exocrine Cells in Transgenic Pigs with Prediabetes [PDF]

International Journal of Molecular Sciences, 2023
Diabetes poses a significant threat to human health. Exocrine pancreatic dysfunction is related to diabetes, but the exact mechanism is not fully understood. This study aimed to describe the pathological phenotype and pathological mechanisms of the pancreas of transgenic pigs (PIGinH11) that was constructed in our laboratory and to compare it with ...
Cong Tao, Kaiyi Zhang, Yanfang Wang
exaly   +5 more sources

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq [PDF]

Neuron
Both neuronal and peripheral tissues become disrupted in Alzheimer's disease (AD). However, a comprehensive understanding of how AD impacts different tissues across the whole organism is lacking. Using Drosophila, we generated an AD Fly Cell Atlas (AD-FCA) based on whole-organism single-nucleus transcriptomes of 219 cell types from flies expressing AD ...
Hongjie Li
exaly   +4 more sources

Perspectives on single-nucleus RNA sequencing in different cell types and tissues [PDF]

Journal of Pathology and Translational Medicine, 2023
Single-cell RNA sequencing has become a powerful and essential tool for delineating cellular diversity in normal tissues and alterations in disease states.
Nayoung Kim, Huiram Kang, Areum Jo, Seung-Ah Yoo, Hae-Ock Lee   +4 more
doaj   +1 more source

Comparative Analysis of Single-cell and Single-nucleus RNA-sequencing in a Rabbit Model of Retinal Detachment-related Proliferative Vitreoretinopathy

Ophthalmology Science, 2023
Purpose: Proliferative vitreoretinopathy (PVR) is the most common cause of failure of retinal reattachment surgery, and the molecular changes leading to this aberrant wound healing process are currently unknown.
Clayton P. Santiago, PhD, MS, Megan Y. Gimmen, BSc, Yuchen Lu, BSc, Minda M. McNally, MS, Leighton H. Duncan, MA, BSc, Tyler J. Creamer, PhD, Linda D. Orzolek, MS, Seth Blackshaw, PhD, Mandeep S. Singh, MD, PhD   +8 more
doaj   +1 more source

Recent advances in deciphering hippocampus complexity using single-cell transcriptomics

Neurobiology of Disease, 2023
Single-cell and single-nucleus RNA sequencing (scRNA-seq and snRNA-seq) technologies have emerged as revolutionary and powerful tools, which have helped in achieving significant progress in biomedical research over the last decade.
Chenxu Chang, Hongyan Zuo, Yang Li
doaj   +1 more source

Integrative snRNA-seq, molecular docking and dynamics simulations identifies Lasmiditan as drug candidate for Alzheimer's disease [PDF]

Clinical and Translational Medicine
Martin C Nwadiugwu, Afolabi Boluwatife Lawrence, Demetrius Maraganore   +2 more
exaly   +2 more sources

Comprehensive snRNA-Seq Datasets of Human and Mouse Podocytopathy Integrated with GWAS of Microalbuminuria. [PDF]

Sci Data
Podocyte (POD) injury is a hallmark of glomerular diseases and a central cause of albuminuria and nephrotic syndrome. Despite the rapid advancements in single-cell sequencing technologies in recent years, POD capture remains limited, resulting in a lack of comprehensive single-cell datasets related to Podocytopathies (PCPs). In this study, we collected
Qing J, Hu J, Wang X, Wu J.
europepmc   +3 more sources

Single cell full-length transcriptome of human subcutaneous adipose tissue reveals unique and heterogeneous cell populations

iScience, 2022
Summary: White adipose tissue (WAT) is a complex mixture of adipocytes and non-adipogenic cells. Characterizing the cellular composition of WAT is critical for identifying where potential alterations occur that impact metabolism.
Katie L. Whytock, Yifei Sun, Adeline Divoux, GongXin Yu, Steven R. Smith, Martin J. Walsh, Lauren M. Sparks   +6 more
doaj   +1 more source

SnRNA-seq reveals seizure-induced remodelling of excitatory and inhibitory neuron populations. [PDF]

Sci Rep
Wang Y, Wang L, Luo K, Chen Z, Xia L.
europepmc   +2 more sources

Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets

Genome Medicine, 2021
Background Human pancreatic islets are a central focus of research in metabolic studies. Transcriptomics is frequently used to interrogate alterations in cultured human islet cells using single-cell RNA-sequencing (scRNA-seq). We introduce single-nucleus
Giorgio Basile, Sevim Kahraman, Ercument Dirice, Hui Pan, Jonathan M. Dreyfuss, Rohit N. Kulkarni   +5 more
doaj   +1 more source