Results 21 to 30 of about 15,972 (195)

Perspectives on single-nucleus RNA sequencing in different cell types and tissues [PDF]

Journal of Pathology and Translational Medicine, 2023
Single-cell RNA sequencing has become a powerful and essential tool for delineating cellular diversity in normal tissues and alterations in disease states.
Nayoung Kim, Huiram Kang, Areum Jo, Seung-Ah Yoo, Hae-Ock Lee   +4 more
doaj   +1 more source

Integrative snRNA‐seq, molecular docking and dynamics simulations identifies Lasmiditan as drug candidate for Alzheimer's disease [PDF]

Clinical and Translational Medicine
Martin C Nwadiugwu, Hong-Wen Deng, Afolabi Boluwatife Lawrence   +2 more
exaly   +2 more sources

Comparative Analysis of Single-cell and Single-nucleus RNA-sequencing in a Rabbit Model of Retinal Detachment-related Proliferative Vitreoretinopathy

Ophthalmology Science, 2023
Purpose: Proliferative vitreoretinopathy (PVR) is the most common cause of failure of retinal reattachment surgery, and the molecular changes leading to this aberrant wound healing process are currently unknown.
Clayton P. Santiago, PhD, MS, Megan Y. Gimmen, BSc, Yuchen Lu, BSc, Minda M. McNally, MS, Leighton H. Duncan, MA, BSc, Tyler J. Creamer, PhD, Linda D. Orzolek, MS, Seth Blackshaw, PhD, Mandeep S. Singh, MD, PhD   +8 more
doaj   +1 more source

Integrating spatial transcriptomics and snRNA-seq data enhances differential gene expression analysis results of AD-related phenotypes [PDF]

Human Genetics and Genomics Advances
Aron S Buchman, David A Bennett, Philip L De Jager   +2 more
exaly   +2 more sources

Recent advances in deciphering hippocampus complexity using single-cell transcriptomics

Neurobiology of Disease, 2023
Single-cell and single-nucleus RNA sequencing (scRNA-seq and snRNA-seq) technologies have emerged as revolutionary and powerful tools, which have helped in achieving significant progress in biomedical research over the last decade.
Chenxu Chang, Hongyan Zuo, Yang Li
doaj   +1 more source

Comprehensive analyses of brain cell communications based on multiple scRNA‐seq and snRNA‐seq datasets for revealing novel mechanism in neurodegenerative diseases [PDF]

CNS Neuroscience and Therapeutics, 2023
Chunlong Zhang, Guiyuan Tan, Yunpeng Zhang   +2 more
exaly   +2 more sources

snRNA‐Seq and Spatial Transcriptome Reveal Cell–Cell Crosstalk Mediated Metabolic Regulation in Porcine Skeletal Muscle [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Fengna Li
exaly   +2 more sources

Single cell full-length transcriptome of human subcutaneous adipose tissue reveals unique and heterogeneous cell populations

iScience, 2022
Summary: White adipose tissue (WAT) is a complex mixture of adipocytes and non-adipogenic cells. Characterizing the cellular composition of WAT is critical for identifying where potential alterations occur that impact metabolism.
Katie L. Whytock, Yifei Sun, Adeline Divoux, GongXin Yu, Steven R. Smith, Martin J. Walsh, Lauren M. Sparks   +6 more
doaj   +1 more source

Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles

Genome Medicine, 2023
Background Single-cell RNA sequencing (scRNA-seq) provides valuable insights into human islet cell types and their corresponding stable gene expression profiles. However, this approach requires cell dissociation that complicates its utility in vivo.
Randy B. Kang, Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa Siddiq, Prashant Rajbhandari, Andrew F. Stewart, Donald K. Scott, Adolfo Garcia-Ocana, Geming Lu   +9 more
doaj   +1 more source

Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets

Genome Medicine, 2021
Background Human pancreatic islets are a central focus of research in metabolic studies. Transcriptomics is frequently used to interrogate alterations in cultured human islet cells using single-cell RNA-sequencing (scRNA-seq). We introduce single-nucleus
Giorgio Basile, Sevim Kahraman, Ercument Dirice, Hui Pan, Jonathan M. Dreyfuss, Rohit N. Kulkarni   +5 more
doaj   +1 more source