Results 81 to 90 of about 844,246 (269)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Brain mechanisms underlying the modulation of heart rate variability when accepting and reappraising emotions

Scientific Reports
Heart rate variability (HRV) has been linked to resilience and emotion regulation (ER). How HRV and brain processing interact during ER, however, has remained elusive.
Simón Guendelman, Laura Kaltwasser, Mareike Bayer, Vittorio Gallese, Isabel Dziobek   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

When is social media use social interaction? Defining mediated social interaction [PDF]

New Media & Society, 2016
This investigation explores the question, when is social media use social interaction? The results of three studies indicated that social media use was rarely considered social interaction. After using social media for 5 or 10 minutes, Study 1 ( N = 116) demonstrated that infrequent, directed social media behavior (e.g.
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The differential impact of autistic traits on implicit and explicit approach-avoidance tendencies toward social and non-social stimuli

Comprehensive Psychiatry
Autistic traits are associated with atypical social behaviors, particularly in approach-avoidance tendencies. However, the differential impact of these traits on responses to social versus non-social stimuli, and the variation of these effects across ...
Muyu Lin, Andreea Tapuc, Magdalena Matyjek, Simon Guendelman, Isabel Dziobek   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Stakeholder acceptance of a robot-assisted social training scenario for autistic children compared to a tablet-computer-based approach

Scientific Reports
Recent studies indicate the potential benefits of robot-assisted therapy (RAT) for children on the autism spectrum (AS), yet acceptance among stakeholders remains unclear due to methodological shortcomings in existing research.
Jonas Frenkel, Simone Kirst, Sandra Naumann, Martina Simon, Julian Sessner, Eileen Roesler, Linda Onnasch, Isabel Dziobek   +7 more
doaj   +1 more source

Assessing communicative-pragmatic ability in telehealth: e-ABaCo in autistic individuals

Frontiers in Psychiatry
IntroductionAutism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by difficulties in social communication. Autistic individuals who are verbally fluent, often show difficulties in pragmatic ability, i.e.
Ilaria Traetta, Ilaria Gabbatore, Alessandra Aimar, Giuseppe Maurizio Arduino, Francesca M. Bosco   +4 more
doaj   +1 more source