Results 91 to 100 of about 237,174 (301)

Old Games, Same Concerns: Examining First Generation Video Games Through Popular Press Coverage from 1972-1985 [PDF]

, 2013
This study explores early video game technology by examining video game fears in the popular press in the 1970s and 1980s. This textual analysis examines games during their formative years, assesses risks associated with new technology, and encourages ...
Rogers, Ryan
core   +1 more source

Exploring individual differences in online addictions: the role of identity and attachment [PDF]

, 2017
Research examining the development of online addictions has grown greatly over the last decade with many studies suggesting both risk factors and protective factors.
A Fossati, A Schimmenti, American Psychiatric Association, BB Christopherson, BE Zamani, C Brezing, C Hazan, CS Andreassen, CS Andreassen, DJ Kuss, E Ceyhan, E Rom, G Fioravanti, H Odacı, HD Grotevant, HM Pontes, J Bowlby, J Bowlby, JA Feeney, JA Oldmeadow, JE Grant, JE Marcia, JH Lin, K Bartholomew, KS Young, L Monacis, L Monacis, Lucia Monacis, M Arabzadeh, MA Jenkins-Guarnieri, Maria Sinatra, Mark D. Griffiths, MD Berzonsky, MD Griffiths, MD Griffiths, MP Lin, NM Petry, RA Elphinston, RZ Goldstein, S Severino, TA Pempek, Valeria de Palo, Ü Morsünbül   +42 more
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Social media addiction and depression among adolescents in two Malaysian states

International Journal of Adolescence and Youth
Addiction to social media addiction is considered a leading risk factor for depression among adolescents, but the relationship needs to be supported empirically. This study investigates the social media addiction level and its association with depression
Stephanie Ann Victor, Muhamad Shamsul Ibrahim, Sarina Yusuf, Norasyikin Mahmud, Khairul Azam Bahari, Loh Yoke Ling, Nur Nadia Abd Mubin   +6 more
doaj   +1 more source

Prevalence and predictors of video game addiction: a study based on a national representative sample of gamers [PDF]

, 2015
Video gaming has become a popular leisure activity in many parts of the world, and an increasing number of empirical studies examine the small minority that appears to develop problems as a result of excessive gaming.
C Hagquist, Charlotte Thoresen Wittek, CJ Ferguson, CS Andreassen, CS Peters, D Bhugra, D Williams, D Williams, Daniel Hanss, DL King, DL King, DL King, EJ Kim, F Rehbein, GS Brunborg, GS Brunborg, H Choo, H Cole, H Pontes, Helge Molde, HG Wenzel, HR Eriksen, IBM Corp Released, JP Charlton, JS Lemmens, JS Wiggins, K Kroenke, L Elliot, M Algeria, Mark D. Griffiths, MB Donellan, MD Griffiths, MD Griffiths, PT Costa, RA Mentzoni, RL Thorndike, Rune Aune Mentzoni, Ståle Pallesen, Turi Reiten Finserås, Y Takata   +39 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Cognitive deficits in problematic internet use : meta-analysis of 40 studies [PDF]

, 2019
© The Royal College of Psychiatrists 2019. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and ...
Chamberlain, Samuel R, Fineberg, Naomi A, Goudriaan, Anna E, Grant, Jon E, Hook, Roxanne, Ioannidis, Konstantinos, Vlies, Simon   +6 more
core   +2 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source