Results 71 to 80 of about 4,121,484 (357)

Reactivity of TEMPO anion as a nucleophile and its applications for selective transformations of haloalkanes or acyl halides to aldehydes [PDF]

, 2004
Sodium 2,2,6,6-tetramethylpiperidine-N-oxide (TEMPO−Na+), generated by reduction of TEMPO· with sodium naphthalenide in THF, reacted with alkyl halides or acyl halides to produce O-alkylated or acylated TEMPOs, which were in turn oxidized with ...
Allen, Anderson, Boger, Braslau, Braslau, Gilbert, Hawker, Henry-Riyad, Hiroyuki Kawafuchi, Hudlicky, Hunter, Inokuchi, Jahn, Johnstone, Kersey, Kilenyi, Kruse, Matyjaszewski, Nahm, Ollivier, Page, Paquette, Ren, Rossi, Saunders, Schämann, Semmelhack, Sholle, Skene, Studer, Togo, Tsutomu Inokuchi, Uneyama, Wetter, Whitesides, Winterfeldt   +35 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Empowering Young Adults as Agents of Household Dietary Change: Findings From a Pilot Study Involving a Digital, Family-Led Sodium Reduction Intervention in Singapore

Current Developments in Nutrition
Background: Unhealthy dietary habits such as high-sodium intake, are socially embedded and often resistant to individual-level interventions. Family-led approaches, where 1 member initiates change within the household, may offer a more effective ...
Kimberly Mei Yi Low, Cindy Mei Jun Chan, Ian Yi Han Ang, Mary Foong-Fong Chong, Shahmir H Ali   +4 more
doaj   +1 more source

LETM1-Mediated K+ and Na+ Homeostasis Regulates Mitochondrial Ca2+ Efflux

Frontiers in Physiology, 2017
Ca2+ transport across the inner membrane of mitochondria (IMM) is of major importance for their functions in bioenergetics, cell death and signaling. It is therefore tightly regulated.
Shane Austin, Mojtaba Tavakoli, Christina Pfeiffer, Julia Seifert, Andrea Mattarei, Diego De Stefani, Mario Zoratti, Mario Zoratti, Karin Nowikovsky   +8 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Urinary electrolyte parameters in sepsis-associated acute kidney injury: A prospective observational study

Indian Journal of Anaesthesia
Background and Aims: Sepsis-associated acute kidney injury (SA-AKI) significantly contributes to morbidity and mortality. Current biomarkers have limitations, necessitating the exploration of alternative indicators.
Rajathadri Hosur Ravikumar, Anjan Trikha, Rashmi Ramachandran, Sudip Kumar Datta, Mrudula Prasanna, Vimi Rewari   +5 more
doaj   +1 more source

Salinity reduces nutrients absorption and efficiency of their utilization in cassava plants

Ciência Rural, 2018
: The objective of this research was to evaluate the influence of salinity on the absorption and utilization of nutrients by cassava. For the study, cassava was submitted to four saline concentrations: 0, 20, 40, and 60mM NaCl.
Jailson Lopes Cruz, Eugênio Ferreira Coelho, Mauricio Antônio Coelho Filho, Andrade Alves dos Santos   +3 more
doaj   +1 more source

The use of topical diclofenac in the pain management of osteoarthritis of the knee [PDF]

, 2006
Osteoarthritis (OA) is a common complaint that affects millions of people worldwide. As there is no cure for OA, drug treatment is the main form of management.
Banning, M
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Ab initio quality neural-network potential for sodium

, 2010
An interatomic potential for high-pressure high-temperature (HPHT) crystalline and liquid phases of sodium is created using a neural-network (NN) representation of the ab initio potential energy surface.
E. Shpil’rain, Hagai Eshet, Jörg Behler, K. Syassen, Michele Parrinello, Rustam Z. Khaliullin, Thomas D. Kühne   +6 more
core   +1 more source