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1996
Research programs investigating the potential use of BNCT for brain tumors have been initiated in Europe and in the U.S. using epithermal neutron beams and either borocaptate sodium (BSH) or boronophenylalanine (BPA) as boron compounds. The BSH biodistribution and pharmacokinetics have been studied in patients with malignant gliomas in Japan1, Germany2,
R. Huiskamp +4 more
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Research programs investigating the potential use of BNCT for brain tumors have been initiated in Europe and in the U.S. using epithermal neutron beams and either borocaptate sodium (BSH) or boronophenylalanine (BPA) as boron compounds. The BSH biodistribution and pharmacokinetics have been studied in patients with malignant gliomas in Japan1, Germany2,
R. Huiskamp +4 more
openaire +1 more source
Oral Oncology, 2004
Boron neutron capture therapy (BNCT) is a unique radiation therapy in which boron compounds are trapped into tumor cells. To determine the biodistribution of boronophenylalanine (BPA) in nude mice carrying oral squamous cell carcinoma (SCC), BPA was administered at a dose of 250 mg/kg body weight intraperitoneally.
Shigeki, Obayashi +7 more
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Boron neutron capture therapy (BNCT) is a unique radiation therapy in which boron compounds are trapped into tumor cells. To determine the biodistribution of boronophenylalanine (BPA) in nude mice carrying oral squamous cell carcinoma (SCC), BPA was administered at a dose of 250 mg/kg body weight intraperitoneally.
Shigeki, Obayashi +7 more
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Large animal normal tissue tolerance using an epithermal neutron beam and borocaptate sodium.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1993Irradiation of the canine head following intravenous Na2B12H11SH (BSH) administration has provided useful information concerning the tolerance of skin and brain to the resultant complex form of irradiation. The effect of the boron capture reaction in skin and brain has provided estimates of the influence of the microscopic dosimetry involved.
P R, Gavin +4 more
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1992
Normal tissue tolerance establishes the dose limitations for any form of radiation therapy. The complexity of the mixed form of radiation from Boron Neutron Capture Therapy (BNCT) makes it difficult to predict normal tissue tolerance. A premise for BNCT is that the ideal boron compound should result in minimal boron concentrations in normal tissues and
S. L. Kraft +4 more
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Normal tissue tolerance establishes the dose limitations for any form of radiation therapy. The complexity of the mixed form of radiation from Boron Neutron Capture Therapy (BNCT) makes it difficult to predict normal tissue tolerance. A premise for BNCT is that the ideal boron compound should result in minimal boron concentrations in normal tissues and
S. L. Kraft +4 more
openaire +1 more source
1992
Epithermal neutron beams are being developed for potential boron neutron capture therapy (BNCT) to allow treatment of deep seated tumors, like glioblastoma multiforme, through the intact skin. The neutron capture cross-sections for elements in normal tissue are several orders of magnitude lower than that for boron but due to the relatively high ...
Patrick R. Gavin +5 more
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Epithermal neutron beams are being developed for potential boron neutron capture therapy (BNCT) to allow treatment of deep seated tumors, like glioblastoma multiforme, through the intact skin. The neutron capture cross-sections for elements in normal tissue are several orders of magnitude lower than that for boron but due to the relatively high ...
Patrick R. Gavin +5 more
openaire +1 more source
2012
The first clinical trials of BNCT were conducted at the Brookhaven Graphic Reactor and the Brookhaven Medical Research Reactor during 1951 and 1952 and at the Massachusetts Institute of Technology Reactor from 1959 to 1962 [3]. The boron compounds used were boric acid and borate as the boron carrier.
Teruyoshi Kageji +2 more
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The first clinical trials of BNCT were conducted at the Brookhaven Graphic Reactor and the Brookhaven Medical Research Reactor during 1951 and 1952 and at the Massachusetts Institute of Technology Reactor from 1959 to 1962 [3]. The boron compounds used were boric acid and borate as the boron carrier.
Teruyoshi Kageji +2 more
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1996
In conventional external beam radiation therapy of intracranial high grade gliomas the dose that can be delivered to the tumor is limited by the tolerance of adjacent normal brain. Boron neutron capture therapy (BNCT) theoretically allows the selective delivery of high linear energy transfer (LET) radiation to brain tumors while at the same time ...
Katharina H. I. Philipp +3 more
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In conventional external beam radiation therapy of intracranial high grade gliomas the dose that can be delivered to the tumor is limited by the tolerance of adjacent normal brain. Boron neutron capture therapy (BNCT) theoretically allows the selective delivery of high linear energy transfer (LET) radiation to brain tumors while at the same time ...
Katharina H. I. Philipp +3 more
openaire +1 more source