Results 101 to 110 of about 560,945 (139)

Additional Impurities Identified in Borocaptate Sodium

1996
Reliable quality control has long been an issue with the production of borocaptate sodium (BSH) because of the toxicity associated with the degradation products of BSH1,2. The quality control issues have largely centered around the oxidation of BSH to the dimer, BSS, and oxidized dimer BSSO.
W. F. Bauer, G. L. Gresham, A. K. Gianotto   +2 more
exaly   +2 more sources

Purity and Quality Determinations of Borocaptate Sodium

1993
The chemical purity or “quality” of any drug can influence it’s action in the body. Knowledge of the chemical purity of the boron delivery agent borocaptate sodium (Na2B12H11SH or BSH) can have a direct effect upon it’s toxicity1, biodistribution2 and the proper interpretation of experimental data3.
A. K. Gianotto, W. F. Bauer
exaly   +2 more sources

Update on Biodistribution of Borocaptate Sodium (BSH) in Patients with Intracranial Tumors

1993
The use of borocaptate sodium (BSH) for Boron Neutron Capture Therapy (BNCT) has been studied since 1968. BSH has shown differential accumulation in rodent tumor models both subcutaneously and intracerebrally implanted. BSH administration to humans for BNCT has also been reported [1,2,3,4], including at this symposium [see report by D. Haritz]. In 1990,
Giuseppe Stragliotto, Daniel Schüpbach, Patrick R. Gavin, Heinz Fankhauser   +3 more
openaire   +1 more source

Biodistribution of boron in dogs with spontaneous intracranial tumors following borocaptate sodium administration.

Cancer research, 1994
Borocaptate sodium (Na2B12H11SH) is a potentially useful compound for boron neutron capture therapy of intracranial tumors. Tumor and normal tissue boron concentrations were evaluated in 30 dogs with naturally occurring intracranial tumors after i.v. borocaptate sodium infusion (55 mg boron/kg).
S L, Kraft, P R, Gavin, C W, Leathers, C E, DeHaan, W F, Bauer, D L, Miller, R V, Dorn, M L, Griebenow   +7 more
openaire   +2 more sources

Response of the central nervous system to fractionated boron neutron capture irradiation: studies with borocaptate sodium

International Journal of Radiation Biology, 1997
The response of the central nervous system (CNS) to fractionated doses of boron neutron capture (BNC) irradiation was assessed using a rat spinal cord model. The thermal neutron beam at the Brookhaven Medical Research Reactor (BMRR) was used for the spinal cord irradiations, with borocaptate sodium (BSH) as the neutron capture agent.
G M, Morris, J A, Coderre, J W, Hopewell, M, Rezvani, P L, Micca, C D, Fisher   +5 more
openaire   +2 more sources

NMR Studies of the Interaction of Borocaptate Sodium with Serum Albumin

1993
The interaction between BSH and serum albumin is of interest because it is related to the pharmacokinetics of BSH. Early research[1]suggested that covalent disulfide bridge might be involved in the interaction, but the idea was contradicted by subsequent studies[2, 3, 4]using11B Nuclear Magnetic Resonance (NMR) spectroscopy. NMR has been proved to be a
Peng-Peng Z. Tang, Martin P. Schweizer, William F. Bauer, Kenneth M. Bradshaw   +3 more
exaly   +2 more sources

Borocaptate sodium (BSH) toxicity issues

1995
ISU`s Center for Toxicology Research has been conducting toxicity testing of borocaptate sodium (BSH) to aid in assessing if proposed human studies of BSH are likely to be acceptably safe. This report describes BSH interactions with other biological agents.
openaire   +1 more source

Effectiveness of Borocaptate Sodium for Boron Neutron Capture Therapy in Malignant Brain Tumors

1996
Since 1990, we have treated fourteen glioblastoma patients by BNCT using BSH according to Hatanaka’s procedures. However, in our early patients, who were almost all advanced cases, good clinical results were not obtained, probably because the tumor to blood ratio of 10B concentration in our BNCT subjects was always under 1 and/or around lOppm ...
Masao Takagaki, Yoshifumi Oda, Yasushi Koda, Haruhiko Kikuchi, Koji Ono   +4 more
openaire   +1 more source

Uptake and Washout of Borocaptate Sodium and Borono-phenylalanine in Cultured Melanoma Cells: A Multi-nuclear NMR Study

Radiation Research, 2000
The cellular uptake and washout of the two principal boron neutron capture therapy (BNCT) agents, borocaptate sodium (BSH) and borono-phenylalanine (BPA), were monitored on-line, noninvasively, using nuclear magnetic resonance (NMR) spectroscopy. The uptake and washout of inorganic borate (B(i)) was also followed for comparison.
V, Panov, Y, Salomon, G W, Kabalka, P, Bendel   +3 more
openaire   +2 more sources

A Treatment Protocol for Bnct of Malignant Gliomas with Borocaptate Sodium (BSH) and Epithermal Neutrons

1993
The research program of the European Concerted Action on Boron Neutron Capture Therapy (BNCT) for Tumors is now approaching a clinical trial with epithermal neutrons and borocaptate sodium (BSH) for 10B delivery. The therapeutic beam prepared with a liquid argon filter has become available for normal tissue tolerance studies in healthy dogs injected ...
Heinz Fankhauser, Patrick R. Gavin, Axel Siefert, Giuseppe Stragliotto   +3 more
openaire   +1 more source