Results 51 to 60 of about 560,945 (139)

Evaluation and Validation of clinical 4.23 T sodium MRI in animals and human: Application of oblique multi-slice spin-echo pulse sequence [PDF]

, 2009
Objective: Application of high-field 4.23 T MRI clinical imager was demonstrated for sodium-magnetic resonance imaging (MRI) data acquisition. Primary hypothesis: Sodium [Na] in brain is MR visible. Secondary hypothesis was, if, application of multislice
Jose Katz, Rakesh Sharma
core  

Hexagonal boron nitride nanomaterials for biomedical applications

BMEMat, Volume 2, Issue 2, June 2024.
Hexagonal boron nitride nanomaterials are a type of characteristic biomedicine. This review summarizes the recent progress of BN nanometarials in the biomedical applications, including drug delivery, boron neutron capture therapy, bioimaging and nanozyme. The advantages and problems of BN nanomedicines are discussed, and the challenges and perspectives
Congling Wang, Yanyang Long, Yuxian Deng, Yuxin Han, Daria Tishkevich, Minh Ngoc Ha, Qunhong Weng   +6 more
wiley   +1 more source

Effects of Boron Neutron Capture Therapy Using Borocaptate Sodium in Combination with a Tumor‐selective Vasoactive Agent in Mice [PDF]

Japanese Journal of Cancer Research, 1998
Boron neutron capture therapy (BNCT) destroys tumor cells by means of α particles and recoil protons emitted by 10B(n,α)7Li reaction. For BNCT to be effective, the tumor/normal tissue concentration ratio of 10B must be larger than 1.0, because neutron distribution is not selective.
Ono, Koji, Masunaga, Shin‐ichiro, Kinashi, Yuko, Takagaki, Masao, Akaboshi, Mitsuhiko, Suzuki, Minoru, Baba, Hideo   +6 more
openaire   +2 more sources

Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer

Radiation Oncology, 2012
Boron neutron capture therapy (BNCT) is a biochemically targeted radiotherapy based on the nuclear capture and fission reactions that occur when non-radioactive boron-10, which is a constituent of natural elemental boron, is irradiated with low energy ...
Barth Rolf F, Vicente M Graca H, Harling Otto K, Kiger W S, Riley Kent J, Binns Peter J, Wagner Franz M, Suzuki Minoru, Aihara Teruhito, Kato Itsuro, Kawabata Shinji   +10 more
doaj   +1 more source

Borax affects cellular viability by inducing ER stress in hepatocellular carcinoma cells by targeting SLC12A5

Journal of Cellular and Molecular Medicine, Volume 28, Issue 10, May 2024.
Abstract Hepatocellular carcinoma (HCC) presents a persistent challenge to conventional therapeutic approaches. SLC12A5 is implicated in an oncogenic capacity and facilitates the progression of cancer. The objective of this investigation is to scrutinize the inhibitory effects of borax on endoplasmic reticulum (ER)‐stress and apoptosis mediated by ...
Ceyhan Hacioglu, Didem Oral
wiley   +1 more source

Borax induces ferroptosis of glioblastoma by targeting HSPA5/NRF2/GPx4/GSH pathways

Journal of Cellular and Molecular Medicine, Volume 28, Issue 7, April 2024.
Abstract Glioblastoma multiforme (GBM) is a highly aggressive and lethal form of primary brain tumour. Borax has been demonstrated to exhibit anti‐cancer activity through cell death pathways. However, the specific impact of borax on ferroptosis in GBM is not well‐established, and the underlying regulatory mechanisms remain unclear.
Cengiz Tuncer, Ceyhan Hacioglu
wiley   +1 more source

Theoretical implication of liganding reactions in axonal sodium channel gating [PDF]

, 1980
Dorogi PL, Neumann E. Theoretical implication of liganding reactions in axonal sodium channel gating. Neurochemistry International. 1980;2:45-51.Mathematical simulation models for measured permeability properties of axonal Na+ channels point to the ...
Dorogi, Peter L., Neumann, Eberhard
core   +1 more source

Human glioblastoma-derived cell membrane nanovesicles: a novel, cell-specific strategy for boron neutron capture therapy of brain tumors

Scientific Reports
Glioblastoma (GBM), one of the deadliest brain tumors, accounts for approximately 50% of all primary malignant CNS tumors, therefore novel, highly effective remedies are urgently needed. Boron neutron capture therapy, which has recently repositioned as a
Alice Balboni, Giorgia Ailuno, Sara Baldassari, Giuliana Drava, Andrea Petretto, Nicole Grinovero, Ornella Cavalleri, Elena Angeli, Andrea Lagomarsino, Paolo Canepa, Alessandro Corsaro, Beatrice Tremonti, Federica Barbieri, Stefano Thellung, Paola Contini, Katia Cortese, Tullio Florio, Gabriele Caviglioli   +17 more
doaj   +1 more source

ADMET-Guided Design and In Silico Planning of Boron Delivery Systems for BNCT: From Transport and Biodistribution to PBPK-Informed Irradiation Windows

Molecules
BNCT (Boron Neutron Capture Therapy) is a binary radiotherapeutic modality in which high LET (Linear Energy Transfer) particles are generated from 10B(n,α)7Li reaction, ideally within boron-loaded tumour cells, so the therapeutic outcome depends ...
Karolina Ewa Wójciuk, Emilia Balcer, Łukasz Bartosik, Michał Dorosz, Natalia Knake, Zuzanna Marcinkowska, Emilia Wilińska, Marcin Zieliński   +7 more
doaj   +1 more source

Transition metal oxides for high performance sodium ion battery anodes [PDF]

, 2014
Sodium-ion batteries (SIBs) are attracting considerable attention with expectation of replacing lithium-ion batteries (LIBs) in large-scale energy storage systems (ESSs).
Yuan, Tianzhi, Yan, Mi, Hu, Meijuan, Jiang, Yinzhu, Zhang, Dan, Xu, Ben, Sun, Wenping   +6 more
core   +1 more source