Results 31 to 40 of about 560,945 (139)

Electrogenic sodium-bicarbonate cotransport in human ciliary muscle cells [PDF]

, 1992
We investigated membrane voltage and intracellular pH (pHi) in cultured human ciliary muscle cells using a cell line (H7CM) and primary-cultured human ciliary muscle cells.
Lepple-Wienhues, A., Stahl, F., E. Tamm, M. Wiederholt, Kuppinger, M., M. Kuppinger, Tamm, Ernst R., A. Lepple-Wienhues, Wiederholt, M., F. Stahl   +9 more
core   +1 more source

Effects of 2 days sodium bicarbonate loading on simulated football performance test [PDF]

, 2011
There is well-documented researches exist on sodium bicarbonate, however, not many studies have examined the effectiveness of this ergogenic aids during prolonged exercises also including a sport specific performance test.
Kurum, Orcun
core   +2 more sources

The effect of sodium valproate in Cushing's disease, Nelson's syndrome and Addison's disease [PDF]

, 1988
We investigated the effect of sodium valproate on plasma ACTH and serum cortisol concentrations in different pathological states of ACTH hypersecretion.
Winkelmann, W., Allolio, B., Kaulen, D., Jaursch-Hancke, C., Reincke, Martin   +4 more
core   +1 more source

Metabolism of borono-phenylalanine-fructose complex (BPA-fr) and borocaptate sodium (BSH) in cancer patients--results from EORTC trial 11001.

, 2010
Within the clinical trial EORTC 11001, patients were infused with (11)B-enriched borono-phenylalanine-fructose complex (BPA-fr), or borocaptate sodium (BSH) solutions, which are used as boron carriers for boron neutron capture therapy. Urine samples were
Basilico F, Mauri PL, Sauerwein W, Bendel P, Wittig A   +4 more
core   +1 more source

Comprehensive study of photon and proton interactions to interpret the radiation parameters of boron derivative drugs for chemoradiotherapy

Journal of Nigerian Society of Physical Sciences
 For chemoradiotherapy applications, this work investigated the photon and proton interaction parameters in five boron-based medications: sodium borocaptate, bortezomib, delanzomib, boronophenylalanine, and boric acid. Photon interaction parameters such
A. M. Olaosun, C. A. Aborisade, D. E. Shian, P. T. Osuolale   +3 more
doaj   +1 more source

In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy

Cells, 2020
Boron neutron capture therapy (BNCT) requires pharmaceutical innovations and molecular-based evidence of effectiveness to become a standard cancer therapeutic in the future. Recently, in Japan, 4-borono-L-phenylalanine (BPA) was approved as a boron agent
Atsushi Fujimura, Seiji Yasui, Kazuyo Igawa, Ai Ueda, Kaori Watanabe, Tadashi Hanafusa, Yasuaki Ichikawa, Sachiko Yoshihashi, Kazuki Tsuchida, Atsunori Kamiya, Shuichi Furuya   +10 more
doaj   +1 more source

The R563Q Mutation of the Beta Subunit of the Epithelial Sodium Channel: Prevalence and Effect [PDF]

, 2009
Hypertension is a major worldwide predictor of morbidity and mortality. The search for genes that contribute to blood pressure is ongoing. The epithelial sodium channel genes were implicated when the beta subunit (SCNN1B, gene ID 6338) was found to have ...
Jones, Dr Erika Sherad Wilshire, Jones, Erika Sherad Wilshire   +1 more
core   +3 more sources

In vitro delivery of borocaptate ions to U87 glioma cells via silk fibroin nanoparticles for boron neutron capture therapy [PDF]

Boron neutron capture therapy (BNCT) is an oncological treatment based on the neutron capture reaction on 10B. The only two compounds approved for phase I/II clinical trials are sodium borocaptate (BSH) and 4-boronophenylalanine (BPA).
Elia Bari, Ian Postuma, Yuan-Hao Liu, Silva Bortolussi, Maria Luisa Torre, Ivana Miletto, Daniela Imperio, Yuan Zhenwei, Luigi Panza, Cinzia Ferrari, Laura Cansolino   +10 more
core   +1 more source

Boron‐embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma

Smart Molecules, EarlyView.
A brain‐targeting multifunctional nanoplatform (DM&Ce6@COF‐Ang) was engineered by employing boron‐enriched APTES‐COF‐1 as both the therapeutic boron agent and the nanocarrier co‐delivery of DMXAA and Ce6. This nanoplatform achieved synergistic tumor‐specific boron delivery, real‐time pharmacokinetic monitoring, and immunomodulation.
Yiming Liu, Xuejian Wang, Bangjian Li, Kun Shao, Jianlong Su, Yang Wang, Lin Cheng, Zhihao Wu, JinRong Li, Guanyi Zhang, Xu Wang, Yuxuan Zhang, Yuanhao Liu, Guangzhe Li   +13 more
wiley   +1 more source

Role of the C-terminal domain in the structure and function of tetrameric sodium channels [PDF]

, 2013
Voltage-gated sodium channels have essential roles in electrical signalling. Prokaryotic sodium channels are tetramers consisting of transmembrane (TM) voltage-sensing and pore domains, and a cytoplasmic carboxy-terminal domain.
Clapham, D.E., Hall, Benjamin A., Wallace, Bonnie A., Claire E. Naylor, Christopher W. M. Kay, Paul G. Decaen, Clapham, David, Hall, B.A., Wallace, B. A., DeCaen, P.G., Naylor, Claire E., Benjamin A. Hall, B. A. Wallace, Bagneris, Claire, Kay, C.W.M., DeCaen, Paul, David E. Clapham, Kay, Christopher W. M.   +17 more
core   +2 more sources