Results 41 to 50 of about 560,945 (139)

Biomimetic Macrophage Cell Membrane‐Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy

Advanced Science, Volume 13, Issue 52, 18 September 2026.
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen, Haoyu You, Hefa Huang, Huihui Chai, Ruize Zhu, Yun Guan, Qisheng Tang, Tianwen Li, Shan Jiang, Houshi Xu, Peng Wang, Yue Wang, Maoyuan Sun, Beining Liu, Zhen Li, Yulai Zeng, Weiqiu Ping, Yanlin Teng, Songlin Yan, Qinghui Li, Long Gu, Tao Sun, Zhifeng Shi   +22 more
wiley   +1 more source

Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain tumor treatment is the presence of blood brain barrier (BBB). BBB comprises different molecular components and transport systems, which in turn create efflux machinery or ...
Arijit Bhowmik, Rajni Khan, Mrinal Kanti Ghosh, Yoshinori Marunaka   +3 more
wiley   +1 more source

Effect of Electroporation on Cell Killing by Boron Neutron Capture Therapy Using Borocaptate Sodium (¹⁰B‐BSH) [PDF]

Japanese Journal of Cancer Research, 1998
The cell membrane permeability of 10B‐enriched borocaptate sodium (BSH) and the extent to which BSH is accumulated in cells are controversial. To elucidate these points and to enhance the accumulation of BSH in cells, the effect of electroporation on boron neutron capture therapy (BNCT) using BSH was investigated.
Ono, Koji, Kinashi, Yuko, Masunaga, Shin‐ichiro, Suzuki, Minoru, Takagaki, Masao   +4 more
openaire   +2 more sources

Emerging agents for boron neutron capture therapy: Biomolecular carriers paving the way for precision radiotherapy

Precision Radiation Oncology, Volume 10, Issue 2, Page 254-264, June 2026.
Boron neutron capture therapy (BNCT) requires key non‐negotiable technical criteria: megadose administration, precise tumor‐specific targeting, favorable biocompatibility, and sustained tumor retention. Overcoming these interconnected challenges fundamentally depends on biomolecular carriers, which are critical for translating the therapeutic potential
Chang Chen, Maosong Yang, Jiheng Wang, Ling Zhang, Shaobo Huang, Xiao Xu, Yang Liu   +6 more
wiley   +1 more source

Application of Nanoparticles on Diagnosis and Therapy in Gliomas

BioMed Research International, Volume 2013, Issue 1, 2013., 2013
Glioblastoma multiforme (GBM) is one of the most deadly diseases that affect humans, and it is characterized by high resistance to chemotherapy and radiotherapy. Its median survival is only fourteen months, and this dramatic prognosis has stilled without changes during the last two decades; consequently GBM remains as an unsolved clinical problem ...
Norma Y. Hernández-Pedro, Edgar Rangel-López, Roxana Magaña-Maldonado, Verónica Pérez de la Cruz, Abel Santamaría del Angel, Benjamín Pineda, Julio Sotelo, Alejandro Sosnik   +7 more
wiley   +1 more source

Accelerator-based boron neutron capture therapy for malignant glioma: a pilot neutron irradiation study using boron phenylalanine, sodium borocaptate and liposomal borocaptate with a heterotopic U87 glioblastoma model in SCID mice [PDF]

International Journal of Radiation Biology, 2020
Purpose: To evaluate the efficacy of boron neutron capture therapy (BNCT) for a heterotopic U87 glioblastoma model in SCID mice using boron phenylalanine (BPA), sodium borocaptate (BSH) and liposomal BSH as boron compounds at a unique, accelerator-based neutron source.Materials and methods: Glioblastoma models were obtained by subcutaneous implantation
Evgenii Zavjalov, Alexander Zaboronok, Vladimir Kanygin, Anna Kasatova, Aleksandr Kichigin, Rinat Mukhamadiyarov, Ivan Razumov, Tatiana Sycheva, Bryan J. Mathis, Sakura Eri B. Maezono, Akira Matsumura, Sergey Taskaev   +11 more
openaire   +2 more sources

Boron delivery agents in BNCT: A mini review of current developments and emerging trends

Nano TransMed
Boron Neutron Capture Therapy (BNCT) is a highly targeted form of radiation therapy offering significant potential for treating hard-to-manage cancers such as glioblastoma, head and neck cancer, and recurrent melanoma [1]. Its effectiveness relies on the
Rolemae M. Murilla, Gladys G. Edilo, Marco Laurence M. Budlayan, Eulogio S. Auxtero, Jr.   +3 more
doaj   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Taming the Immiscibility of Gold, Iron, and Boron to Craft Chemodegradable Nanoparticles for Multimodal Imaging and Radiotherapy

Advanced Healthcare Materials, Volume 15, Issue 16, 24 April 2026.
Over half of cancer patients undergo radiotherapy. Laser ablation enabled the synthesis of immiscible Au‐Fe‐B nanoparticles designed as degradable bimodal radiosensitizers for X‐ray radiotherapy (XRT), boron neutron capture therapy (BNCT), and bimodal imaging for X‐ray computed tomography (CT) and magnetic resonance imaging (MRI). These nanosensitizers
Michael Bissoli, Clara M.G. de Faria, Veronica Torresan, Maria Assunta Lacavalla, Mattia Cattelan, Denis Badocco, Paolo Pastore, Pasquina Marzola, Laura Cansolino, Cinzia Ferrari, Ian Postuma, Riccardo Vago, Silva Bortolussi, Antonello E. Spinelli, Daniel Forrer, Vincenzo Amendola   +15 more
wiley   +1 more source

Boric Acid Suppresses Cell Survival by Triggering Endoplasmic Reticulum Stress‐Induced Autophagy in Cervical Cancers

Journal of Cellular and Molecular Medicine, Volume 29, Issue 14, July 2025.
ABSTRACT Cervical cancer ranks as the fourth most common cancer amongst women globally. This study aimed to investigate boric acid's effects on endoplasmic reticulum (ER) stress and autophagy signalling pathways in cervical cancer cells. We first assessed boric acid's effects on cell viability and proliferation in HUF and HeLa cell lines. Subsequently,
Betul Keyif, Ceyhan Hacioglu
wiley   +1 more source