Results 61 to 70 of about 644,536 (348)

Do sodium channel proteolytic fragments regulate sodium channel expression? [PDF]

Channels, 2017
The cardiac voltage-gated sodium channel (gene: SCN5A, protein: NaV1.5) is responsible for the sodium current that initiates the cardiomyocyte action potential. Research into the mechanisms of SCN5A gene expression has gained momentum over the last few years.
Onwuli, Donatus O., Yañez-Bisbe, Laia, Pinsach-Abuin, Mel·lina, Tarradas, Anna, Brugada, Ramon, Greenman, John, Pagans, Sara, Beltran-Alvarez, Pedro   +7 more
openaire   +3 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Sodium Channels and Mammalian Sensory Mechanotransduction [PDF]

, 2012
Background: Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation.
Edith Hummler, Fan Wang, Francois Rugiero, Hannes Kiesewetter, John N Wood, Mohammed A Nassar, Rachel Hatch, Ramin Raouf   +7 more
core   +4 more sources

Roles of Voltage-Dependent Sodium Channels in Neuronal Development, Pain, and Neurodegeneration

Journal of Pharmacological Sciences, 2006
Besides initiating and propagating action potentials in established neuronal circuits, voltage-dependent sodium channels sculpt and bolster the functional neuronal network from early in embryonic development through adulthood (e.g., differentiation of ...
Akihiko Wada
doaj   +1 more source

Influences: Sodium channel excitement [PDF]

Journal of General Physiology, 2018
Mandel reflects on the influence that a very broad training had on her scientific career.
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

First-Principles Study on Electron Conduction in Sodium Nanowire

, 2004
We present detailed first-principles calculations of the electron-conduction properties of a three-sodium-atom nanowire suspended between semi-infinite crystalline Na(001) electrodes during its elongation.
B?ttiker M, Chelikowsky J R, Costa-Kr?mer J L, Costa-Kr?mer J L, Datta S, Egami Y, Fujimoto Y, Hansen K, Kikuji Hirose, Krans J M, Lang N D, Lang N D, Messiah A, Ono T, Perdew J P, Sasaki T, Sim H S, Takashi Sasaki, Tomoya Ono, Troullier N, van Ruitenbeek J M, Yoshiyuki Egami   +21 more
core   +2 more sources

MicroED structure of the NaK ion channel reveals a Na+ partition process into the selectivity filter. [PDF]

, 2018
Sodium (Na+) is a ubiquitous and important inorganic salt mediating many critical biological processes such as neuronal excitation, signaling, and facilitation of various transporters.
Gonen, Tamir, Liu, Shian
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Skeletal Muscle Na+ Channel Disorders

Frontiers in Pharmacology, 2011
Five inherited human disorders affecting skeletal muscle contraction have been traced to mutations in the gene encoding the voltage-gated sodium channel Nav1.4.
Dina eSimkin, Saïd eBendahhou
doaj   +1 more source