Results 101 to 110 of about 511,275 (351)

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Channel diffusion of sodium in a silicate glass

, 2001
We use classical molecular dynamics simulations to study the dynamics of sodium atoms in amorphous Na$_2$O-4SiO$_2$. We find that the sodium trajectories form a well connected network of pockets and channels. Inside these channels the motion of the atoms
A.K. Jonscher, B. Roling, D.E. Day, D.L. Sidebottom, G.J. Kramer, G.N. Greaves, G.N. Greaves, G.N. Greaves, H. Kahnt, J. Horbach, J. Horbach, J. Oviedo, J.P. Hansen, K. Funke, K. Funke, M.D. Ingram, M.D. Ingram, N. Bansal, P. Jund, P. Maass, P. Maass, Philippe Jund, Rémi Jullien, S. Sen, S. Sen, S.R. Elliott, Walter Kob   +26 more
core   +1 more source

Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing [PDF]

, 2012
Voltage-gated sodium channels are vital membrane proteins essential for electrical signalling; in humans, they are key targets for the development of pharmaceutical drugs. Here we report the crystal structure of an open-channel conformation of NavMs, the
A Lampert, A Vagin, AJ McCoy, AM Powl, AM Waterhouse, AO O’Reilly, D Ren, D Shaya, DA Doyle, DP Klose, E Blanc, EC McCusker, GM Clayton, IH van Stokkum, J Payandeh, JD Thompson, JG Lees, JG Lees, K Charalambous, K Irie, L Whitmore, M Petrek, M Strong, NA Baker, P Emsley, R Koishi, RA Laskowski, RM Keegan, SB Long, VB Chen, W Kabsch, W Kabsch, Y Zhao, Y Zhao   +33 more
core   +2 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Systematic Study of Binding of μ-Conotoxins to the Sodium Channel NaV1.4

Toxins, 2014
Voltage-gated sodium channels (NaV) are fundamental components of the nervous system. Their dysfunction is implicated in a number of neurological disorders, such as chronic pain, making them potential targets for the treatment of such disorders.
Somayeh Mahdavi, Serdar Kuyucak
doaj   +1 more source

Voltage-gated sodium channels: new targets in cancer therapy? [PDF]

, 2006
Early detection and treatment of cancers have increased survival and improved clinical outcome. The development of metastases is often associated with a poor prognostic of survival. Finding early markers of metastasis and developing new therapies against
Besson, Pierre, Le Guennec, Jean-Yves, Potier, Marie, Roger, Sébastien, Vandier, Christophe   +4 more
core   +2 more sources

How Epilepsy Changes Sodium Channels [PDF]

Epilepsy Currents, 2003
Induction of Neonatal Sodium Channel II and III α-Isoform mRNAs in Neurons and Microglia After Status Epilepticus in the Rat Hippocampus Aronica E, Yankaya B, Troost D, van Vliet EA, Lopes da Silva FH, Gorter JA Eur J Neurosci 2001;13(6):1261 Sodium channels (NaChs) regulate neuronal excitability in both physiologic and pathological conditions ...
openaire   +2 more sources

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury

Archives of Medical Science, 2019
Introduction RS100642, a mexiletine analogue, is a novel sodium channel blocker with neuroprotective and antioxidant activities. The protectivity of RS100642, which has been shown against focal cerebral ischemia, was investigated in global cerebral ...
Suat Kamisli, Cenk Basaran, Kadir Batcioglu, Mustafa Namık Oztanir, Mehmet Gul, Basri Satilmis, Ayse Burcin Uyumlu, Basak Kayhan, Metin Genc   +8 more
doaj   +1 more source

A novel strategy for screening mutations in the voltage-gated sodium channel gene of Aedes albopictus based on multiplex PCR-mass spectrometry minisequencing technology [PDF]

, 2023
Qunzheng Mu, Xin Zhao, Fengfeng Li, Wenyu Li, Xinxin Zhou, Xinchang Lun, Yiguan Wang, Dongdong Hua, Qiyong Liu, Di Xiao, Fengxia Meng   +10 more
openalex   +1 more source