Results 141 to 150 of about 247,522 (255)

Sodium Channels [PDF]

Science-Business eXchange, 2012
openaire   +2 more sources

Voltage-gated sodium channels in the nervous system: Molecular physiology to therapeutic interventions. [PDF]

Neural Regen Res
Li N, Yan L, Peng A, Fu X, Qin H, Yao K, Yao K.   +6 more
europepmc   +1 more source

Engineering Nanoplatforms for Alzheimer's Disease Detection via Biomolecular Corona Proteomic and Lipidomic Profiling

Advanced Healthcare Materials, EarlyView.
Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco, Roberto Baretta, Andrea Di Fonzo, Andrea Armirotti, Stefano Cinti, Mara Mirasoli, Marco Frasconi, Claudia Corbo   +7 more
wiley   +1 more source

A Modular Liver–Microbial Microfluidic Platform to Evaluate Therapeutic and Adverse Effects of Microbial Metabolites

Advanced Healthcare Materials, EarlyView.
This study introduces a modular microfluidic platform that connects liver cells with live microbes to mimic key aspects of the gut–liver interaction in steatosis. Using this system, both microbial metabolites and live bacteria significantly reduced fat accumulation in liver cells, but live microbes triggered inflammation and broader metabolic changes ...
Hsih‐Yin Tan, In Young Hwang, Nanthini Jayabalan, Hui Ling Lee, Louis Jun Ye Ong, Chwee Teck Lim, Matthew Wook Chang, Yi‐Chin Toh   +7 more
wiley   +1 more source

Voltage-Gated Sodium Channels: A Therapeutic Target in Ischemic Heart Disease. [PDF]

Rev Cardiovasc Med
Zhang XL, Wei TP, Yang F, Liu HH, Qian LL, Wang RX.   +5 more
europepmc   +1 more source

Bioprinting High‐Cell‐Density Cardiac Tissue Constructs With Sustained Contractile Function

Advanced Healthcare Materials, EarlyView.
Contractile cardiomyocytes in 3D culture provide insights into the behavior of the heart. Combining a 3D bioprinting approach with a multi‐electrode array allows the development of the 3D culture to be monitored over time, and matured cultures allow the effect of drugs on cardiac function to be modelled, replicating effects seen in clinical application.
Priscila Melo, Wing Tai Tung, Harvey Lewis, Kavin Hettiarachchilage, Babis Tzivelekis, Rolando Berlinguer‐Palmini, Ana Marina Ferreira, Jason Gill, Kenneth Dalgarno   +8 more
wiley   +1 more source

Pharmacological targeting and characterization of Voltage-Gated Sodium Channels (VGSCs) expressed in the high-grade glioma microenvironment. [PDF]

BMC Cancer
Fletcher EV, Shard C, Boyle Y, Milligan CJ, Cross RSN, Jones AC, Francis A, Dewdney B, Barker M, Rezaeiravesh S, Ng ZY, Yeow Y, Kuznetsova I, Jones ME, Ormsby RJ, Poonnoose SI, Patil A, Valvi S, Jenkins MR, Forrest ARR, Petrou S, Gomez GA, Johns TG.   +22 more
europepmc   +1 more source

A 3D‐Printed Vascular‐Like Perfusion Tumor‐on‐a‐Chip Recapitulates High‐Grade Breast Cancer With in Vivo‐Relevant Drug Resistance

Advanced Healthcare Materials, EarlyView.
A high‐resolution 3D‐printed tumor‐on‐a‐chip platform sustains breast cancer tissues at in vivo–like cell densities through vascular‐like perfusion. This engineered system recapitulates grade‐dependent molecular features and exhibits drug‐resistance profiles that uniquely align with clinically relevant Cmax values.
Geonhui Lee, Bingjie Sun, Nicholas X. Fang, Chunguang Xia   +3 more
wiley   +1 more source

Beta Toxins Isolated from the Scorpion <i>Centruroides hirsutipalpus</i> (Scorpiones; Buthidae) Affect the Function of Sodium Channels of Mammals. [PDF]

Toxins (Basel)
Valdez-Velazquez LL, Olamendi-Portugal T, Restano-Cassulini R, Riaño-Umbarila L, Jiménez-Vargas JM, Zamudio F, Salazar-Monge H, Becerril B, Possani LD.   +8 more
europepmc   +1 more source

Multifunctional Catechol‐Functionalized Cellulose Hydrogels for the Minimally Invasive Treatment of Acute Optic Nerve Injuries

Advanced Healthcare Materials, EarlyView.
Catechol‐functionalized cellulose hydrogels are developed as injectable, bioadhesive platforms for retinal neuroprotection. The hydrogels exhibit tunable rheological and mechanical properties, strong tissue adhesion, and sustained antioxidative activity.
Kai‐Hsiang Chang, Yi‐Ke Lin, Wei‐Li Chen, Ta‐Ching Chen, Jiashing Yu   +4 more
wiley   +1 more source