Advanced Functional Materials, EarlyView.Many cancer nanotherapeutics, while potent, suffer from the inability to escape from the tumor vasculature, especially in the absence of endothelial permeability. In this work, ultrasmall gold nanoclusters could engineer nanomaterials induced endothelial leakiness (NanoEL) and harness strong NIR induced photothermal characteristics to suppress tumor ...
Nengyi Ni +8 more
wiley +1 more source
<i>In silico</i> exploration of bioactive secondary metabolites with anesthetic effects on sodium channels Nav 1.7, 1.8, and 1.9 in painful human dental pulp. [PDF]
Mol PainSaini RS +3 more
europepmc +1 more source
Novel Functional Materials via 3D Printing by Vat Photopolymerization
Advanced Functional Materials, EarlyView.This Perspective systematically analyzes strategies for incorporating functionalities into 3D‐printed materials via Vat Photopolymerization (VP). It explores the spectrum of achievable functionalities in recently reported novel materials—such as conductive, energy‐storing, biodegradable, stimuli‐responsive, self‐healing, shape‐memory, biomaterials, and
Sergey S. Nechausov +3 more
wiley +1 more source
Similar excitability through different sodium channels and implications for the analgesic efficacy of selective drugs. [PDF]
ElifeXie YF, Yang J, Ratté S, Prescott SA.
europepmc +1 more source
Advanced Functional Materials, EarlyView.This study develops a self‐powered permeable electronic dressing (SPED) that synergistically integrates exudate management, electrical stimulation, and on‐demand drug delivery. The dressing effectively absorbs exudate while demonstrating potent antibacterial activity and accelerated tissue regeneration in diabetic mouse models, thereby promoting ...
Jiaheng Liang +12 more
wiley +1 more source
Ranolazine: a potential anti-metastatic drug targeting voltage-gated sodium channels. [PDF]
Br J CancerDjamgoz MBA.
europepmc +1 more source
Advanced Functional Materials, EarlyView.MagPiezo enables wireless activation of endogenous Piezo1 channels without genetic modification using 19 nm magnetic nanoparticles and low‐intensity magnetic fields. It generates torque forces at the piconewton scale to trigger mechanotransduction in endothelial cells, standing as a novel platform to interrogate and manipulate Piezo1 activity in vitro.
Susel Del Sol‐Fernández +7 more
wiley +1 more source
Peripherally targeted analgesia via AAV-mediated sensory neuron-specific inhibition of multiple pronociceptive sodium channels. [PDF]
J Clin InvestShin SM +7 more
europepmc +1 more source
Nucleation‐Controlled Reconstruction of CuOx for Selective CO2 Electroreduction
Advanced Functional Materials, EarlyView.The ratio of oxygen vacancies (Ov) and exposed Cu2O (111)/(200) of CuOx precatalyst is modulated by nucleation control of Cu(OH)2 precursor. Low Ov ratio and high ratio of Cu2O (111)/(200) in slow‐nucleated CuOx reconstructs to high‐coordinated oxide‐derived copper (OD‐Cu) during electrochemical CO2 reduction reaction (CO2RR) and exhibits enhanced ...
Ying Ying Ch'ng +14 more
wiley +1 more source
Voltage-gated sodium channels in genetic epilepsy: up and down of excitability. [PDF]
J NeurochemRusina E +4 more
europepmc +1 more source