Results 211 to 220 of about 247,522 (255)

Amiloride and the sodium channel

Naunyn-Schmiedeberg's Archives of Pharmacology, 1974
Amiloride and the sodium channel. The diuretic drugs amiloride and triamterene have been used as probes for sodium channels in the mucosal surface of isolated frog skin. Both substances interact competitively with sodium for the channel. Using 14C-amiloride measurements were made of the number of channels present in the mucosal surface under a variety ...
A W, Cuthbert, W K, Shum
openaire   +2 more sources

Introduction to Sodium Channels

2014
Voltage-gated sodium channels (VGSCs) are present in many tissue types within the human body including both cardiac and neuronal tissues. Like other channels, VGSCs activate, deactivate, and inactivate in response to changes in membrane potential.
Colin H, Peters, Peter C, Ruben
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Cardiac Sodium Channel Diseases

Clinical Chemistry and Laboratory Medicine, 2003
In the last few years, a very active line of research took place after the first identification of SCN5A mutations associated with an inherited form of cardiac arrhythmias and sudden death, the LQT3 variant of the long QT syndrome. Subsequently, two allelic diseases additional to LQT3 were shown to be due to mutations in the same gene, the Brugada ...
Napolitano,C, Rivolta, I, Priori, SG
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Sodium Channel Trafficking

2017
Voltage-gated sodium channels (VGSC) are critical determinants of cellular electrical activity through the control of initiation and propagation of action potential. To ensure this role, these proteins are not consistently delivered to the plasma membrane but undergo drastic quality controls throughout various adaptive processes such as biosynthesis ...
Mercier, Aurélie, Bois, Patrick, Chatelier, Aurelien   +2 more
openaire   +3 more sources

Sodium Channels and Pain

2015
Human and mouse genetic studies have led to significant advances in our understanding of the role of voltage-gated sodium channels in pain pathways. In this chapter, we focus on Nav1.7, Nav1.8, Nav1.9 and Nav1.3 and describe the insights gained from the detailed analyses of global and conditional transgenic Nav knockout mice in terms of pain behaviour.
Abdella M, Habib, John N, Wood, James J, Cox   +2 more
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Sodium channels and pain

Neurology, 2007
Voltage-gated sodium (Na+) channels play a key role in membrane excitation in neurons. These channels have a critical role in the development and maintenance of several pain syndromes, including inflammatory pain, neuropathic pain, and central pain associated with spinal cord injury.1–4 The increasing understanding of the molecular organization ...
openaire   +2 more sources

Bacterial Sodium Channels: Models for Eukaryotic Sodium and Calcium Channels

2014
Eukaryotic sodium and calcium channels are made up of four linked homologous but different transmembrane domains. Bacteria express sodium channels comprised of four identical subunits, each being analogous to a single homologous domain of their eukaryotic counterparts.
openaire   +2 more sources

Epithelial Sodium Channel: A Ligand-Gated Channel?

Nephron Physiology, 2004
The epithelial sodium channel (ENaC) is a key component of the transepithelial Na⁺ transport. In epithelia, it is responsible for the maintenance of Na⁺ balance (which in turn controls extracellular fluid volume and arterial blood pressure) and the regulation of airway surface fluid. While the regulation of
Horisberger JD, Chraïbi A
openaire   +3 more sources

A Sodium Channel Model

Annals of the New York Academy of Sciences, 1993
C, Sato, G, Matsumoto
openaire   +2 more sources

Structure and Pharmacology of Voltage-Gated Sodium and Calcium Channels

Annual Review of Pharmacology and Toxicology, 2020
William Catterall, Tamer M Gamal El-Din, Michael Lenaeus   +2 more
exaly