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Sodium channels and transporters in the myometrium
Current Opinion in Physiology, 2020In excitable cells such as neurons and cardiomyocytes, sodium influx across the plasma membrane contributes to the resting membrane potential, and sodium is the key ion for generating action potentials. In myometrial smooth muscle cells, however, the functions of sodium influx have not been fully elucidated.
Chinwendu Amazu +3 more
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Bacterial Sodium Channels: Models for Eukaryotic Sodium and Calcium Channels
2014Eukaryotic sodium and calcium channels are made up of four linked homologous but different transmembrane domains. Bacteria express sodium channels comprised of four identical subunits, each being analogous to a single homologous domain of their eukaryotic counterparts.
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Sodium channel mutations and arrhythmias
Nature Reviews Cardiology, 2009Since the identification of the first SCN5A mutation associated with long QT syndrome in 1995, several mutations in this gene for the alpha subunit of the cardiac sodium channel have been identified in a heterogeneous subset of cardiac rhythm syndromes, including Brugada syndrome, progressive cardiac conduction defect, sick sinus node syndrome, atrial ...
Ruan Y, Liu N, PRIORI, SILVIA GIULIANA
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Gating of sodium and potassium channels
The Journal of Membrane Biology, 1985Voltage-dependent conductances play a fundamental role in the generation and propagation of the action potential. Hodgkin and Huxley (1952c) made a complete description of the membrane currents underlying the generation of the impulse. Their description introduced the concepts of separate pathways for sodium and potassium (today called Na and K ...
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Epithelial Sodium Channels (ENaCs)
2015Amiloride-sensitive epithelial sodium (Na+) channels (ENaCs) play a crucial role in Na+ transport and fluid reabsorption in the kidney, lung, and colon. ENaC is made up of three homologous subunits, α, β, and γ. The magnitude of ENaC-mediated Na+ transport in epithelial cells depends on the average open probability of the channels and the number of ...
Chang Song, He-Ping Ma, Douglas C. Eaton
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Gating in Sodium Channels of Nerve
Annual Review of Physiology, 1976During the period 1937-1952 the study of electrical excitability mechanisms in axons matured from discoveries of membrane impedance changes to a complete kinetic description of ionic permeability changes in the squid giant axon (35). There followed a period of relative stagnation while the results on squid were rechecked and new voltage clamp methods ...
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Sodium channels and pain therapy
Current Opinion in Anaesthesiology, 2000Researchers have characterized changes in the nervous system that occur in response to tissue injury in order to identify possible targets for novel therapeutic interventions for the treatment of pain. That blockers of voltage-gated sodium channels (VGSCs) are clinically effective for the treatment of pain associated with certain types of tissue injury
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Structure and Pharmacology of Voltage-Gated Sodium and Calcium Channels
Annual Review of Pharmacology and Toxicology, 2020Michael J Lenaeus, Tamer M Gamal El-Din
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