Results 221 to 230 of about 240,167 (261)
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Current Opinion in Nephrology and Hypertension, 1994
The highly selective amiloride-sensitive epithelial sodium channel is expressed in the distal part of the nephron, the distal colon, and the lung. It plays a critical role in the control of sodium balance, extracellular volume, blood pressure, and of fluid reabsorption in the lung. The primary structure of the rat epithelial sodium channel has recently
B C, Rossier +3 more
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The highly selective amiloride-sensitive epithelial sodium channel is expressed in the distal part of the nephron, the distal colon, and the lung. It plays a critical role in the control of sodium balance, extracellular volume, blood pressure, and of fluid reabsorption in the lung. The primary structure of the rat epithelial sodium channel has recently
B C, Rossier +3 more
openaire +2 more sources
Cardiac Sodium Channel Diseases
Clinical Chemistry and Laboratory Medicine, 2003In the last few years, a very active line of research took place after the first identification of SCN5A mutations associated with an inherited form of cardiac arrhythmias and sudden death, the LQT3 variant of the long QT syndrome. Subsequently, two allelic diseases additional to LQT3 were shown to be due to mutations in the same gene, the Brugada ...
Napolitano,C, Rivolta, I, Priori, SG
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2017
Voltage-gated sodium channels (VGSC) are critical determinants of cellular electrical activity through the control of initiation and propagation of action potential. To ensure this role, these proteins are not consistently delivered to the plasma membrane but undergo drastic quality controls throughout various adaptive processes such as biosynthesis ...
Mercier, Aurélie +2 more
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Voltage-gated sodium channels (VGSC) are critical determinants of cellular electrical activity through the control of initiation and propagation of action potential. To ensure this role, these proteins are not consistently delivered to the plasma membrane but undergo drastic quality controls throughout various adaptive processes such as biosynthesis ...
Mercier, Aurélie +2 more
openaire +3 more sources
Current Opinion in Pharmacology, 2015
Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the periphery. Sensory fibers contain a heterogeneous yet specific distribution of voltage-gated sodium channel isoforms. Major efforts by industry and academic groups are underway to develop medicines that interrupt inappropriate ...
Kevin, Kwong, Michael J, Carr
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Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the periphery. Sensory fibers contain a heterogeneous yet specific distribution of voltage-gated sodium channel isoforms. Major efforts by industry and academic groups are underway to develop medicines that interrupt inappropriate ...
Kevin, Kwong, Michael J, Carr
openaire +2 more sources
Current Opinion in Pharmacology, 2001
Increased knowledge of the molecular diversity of sodium channel alpha- and beta-subunits, and their distribution of expression have been highlights of the past year. The development of subtype-specific channel blockers remains elusive, but the discovery of selective inhibitors such as mu-conotoxins promises useful antagonists in the near future.
J N, Wood, M, Baker
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Increased knowledge of the molecular diversity of sodium channel alpha- and beta-subunits, and their distribution of expression have been highlights of the past year. The development of subtype-specific channel blockers remains elusive, but the discovery of selective inhibitors such as mu-conotoxins promises useful antagonists in the near future.
J N, Wood, M, Baker
openaire +2 more sources
Epithelial Sodium Channels (ENaCs)
2015Amiloride-sensitive epithelial sodium (Na+) channels (ENaCs) play a crucial role in Na+ transport and fluid reabsorption in the kidney, lung, and colon. ENaC is made up of three homologous subunits, α, β, and γ. The magnitude of ENaC-mediated Na+ transport in epithelial cells depends on the average open probability of the channels and the number of ...
Chang Song, He-Ping Ma, Douglas C. Eaton
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Epithelial Sodium Channel: A Ligand-Gated Channel?
Nephron Physiology, 2004The epithelial sodium channel (ENaC) is a key component of the transepithelial Na<sup>+</sup> transport. In epithelia, it is responsible for the maintenance of Na<sup>+</sup> balance (which in turn controls extracellular fluid volume and arterial blood pressure) and the regulation of airway surface fluid. While the regulation of
Jean-Daniel, Horisberger +1 more
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The physiological function of different voltage-gated sodium channels in pain
Nature Reviews Neuroscience, 2021George Goodwin, Stephen B Mcmahon
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Structure and Pharmacology of Voltage-Gated Sodium and Calcium Channels
Annual Review of Pharmacology and Toxicology, 2020Michael J Lenaeus, Tamer M Gamal El-Din
exaly
Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells
Nature Reviews Nephrology, 2014Kristina Kusche-Vihrog +2 more
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