Results 21 to 30 of about 626 (142)

Pharmacotherapy of Narcolepsy: Focus on Sodium Oxybate

, 2010
Narcolepsy is a complex disease with multiple symptoms that include excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep paralysis. Pharmacologic management of patients with narcolepsy is based on treating these symptoms. Sodium
Sanjeev V. Kothare, Joseph Kaleyias
core   +1 more source

Sodium Oxybate for Excessive Daytime Sleepiness and Sleep Disturbance in Parkinson Disease: A Randomized Clinical Trial [PDF]

, 2018
IMPORTANCE: Sleep-wake disorders are a common and debilitating nonmotor manifestation of Parkinson disease (PD), but treatment options are scarce. OBJECTIVE: To determine whether nocturnal administration of sodium oxybate, a first-line treatment ...
Christian R. Baumann, Büchele, Fabian, Maric, A, Hackius, M, Daniel Waldvogel, Waldvogel, Daniel, Hägele-Link, Stefan, Hackius, Marc, Omlor, W, Werth, Esther, Lukas L. Imbach, Stefan Hägele-Link, Maric, Angelina, Imbach, LL, Imbach, Lukas L, Omlor, Wolfgang, Esther Werth, Baumann, CR, Sebastian R. Schreglmann, Schreglmann, Sebastian R, Schreglmann, SR, Werth, E, Fabian Büchele, Büchele, F, Angelina Maric, Wolfgang Omlor, Hägele-Link, S, Baumann, Christian R, Marc Hackius, Waldvogel, D   +29 more
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Efficiency of sodium oxybate in episodic cluster headache

, 2013
We report the case of a 60-year-old man suffering from episodic cluster headache treated successfully with sodium oxybate.
Hidalgo, H, Kallweit, U, Uhl, V, Gantenbein, A R, Sándor, P S   +4 more
core   +1 more source

Successful Treatment of Narcolepsy and Cataplexy: A Review

Canadian Respiratory Journal, 2005
A 25-year-old woman with narcolepsy and cataplexy was treated with well-recognized drugs for these conditions. Because she did not respond, a decision was made to treat her with sodium oxybate.
B Lockrane, P Bhatia, Robin Gore
doaj   +1 more source

Sodium oxybate plus nalmefene for the treatment of alcohol use disorder: A case series.

, 2016
The treatment of alcohol use disorder still remains a challenge. The efficacy of the combined pharmacological treatment for alcohol use disorder has been widely investigated with controversial results.
BERNARDI, MAURO, Addolorato, G, D'Amore, Antonio, Maremmani, Angelo G. I., Caputo, F, Caputo, Francesco Maria, Caputo, Fabio, Addolorato, Giovanni, Maremmani, A, D’Amore, A, DOMENICALI, MARCO, Zoli, Giorgio, Maremmani, Icro, Zoli, G   +13 more
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Green spectrofluorimetric method for quantification of sodium oxybate in pharmaceutical and plasma samples

Scientific Reports
Sodium oxybate is a newly approved oral treatment for narcolepsy-related cataplexy and excessive daytime sleepiness. It has been misused recreationally and implicated in drug-facilitated crimes.
Reem M. Alnemari, Farooq M. Almutairi, Muneef M. Aldhafeeri, Maram H. Abduljabbar, Rami M. Alzhrani, Yusuf S. Althobaiti, Musaad M. Althobaiti, Sherif Ramzy, Atiah H. Almalki   +8 more
doaj   +1 more source

Cerebrospinal fluid orexin testing in Australians with narcolepsy type 1

Internal Medicine Journal, EarlyView.
Abstract A clinical diagnosis of narcolepsy type 1 can be challenging, particularly in relation to cataplexy. Despite its specificity, cerebrospinal fluid (CSF) orexin testing is under‐utilised in Australasia. We describe the use of CSF orexin testing in 15 clinically indicated patients from two sleep centres, highlighting its utility in the ...
Mario Fernando, Gianluca Cotta, Samantha Kung, Grace Garden, Jian Eu Tai, Elie Matar, Brendon Yee, Claire Ellender, Sheila Sivam   +8 more
wiley   +1 more source

Treatment of paediatric narcolepsy with sodium oxybate: a double-blind, placebo-controlled, randomised-withdrawal multicentre study and open-label investigation

, 2018
Background: Narcolepsy is a lifelong neurological disorder with onset commonly in childhood or adolescence. No drugs are indicated for cataplexy and excessive daytime sleepiness in paediatric patients with narcolepsy.
Ruoff, Chad, Dauvilliers, Yves, Wang, Youyu Grace, Michel Lecendreux, Rosen, Carol, Carol L Rosen, Parvataneni, Rupa, Chad Ruoff, Plazzi, Giuseppe, Guinta, Diane, Giuseppe Plazzi, Diane Guinta, Black, Jed, Rosen, Carol L, Youyu Grace Wang, Rupa Parvataneni, Jed Black, Yves Dauvilliers, Lecendreux, Michel, Mignot, Emmanuel, Emmanuel Mignot   +20 more
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Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Sodium oxybate therapy for the treatment of alcohol withdrawal syndrome and the maintenance of alcohol abstinence

, 2017
Gamma-hydroxybutyrate (GHB or sodium oxybate) is both an exogenous and endogenous molecule with neuromodulator properties. In the United States, GHB is an approved drug for the treatment of narcolepsy and narcolepsy with cataplexy in adults.
Pichini, Simona, Michele Navarra, Ventura Spagnolo, E, Calapai, Fabrizio, Simona Pichini, Mannucci, Carmen, Gangemi, Sebastiano, Gioacchino Calapai, Navarra, Michele, Sebastiano Gangemi, Elvira Ventura Spagnolo, Calapai, Gioacchino, Carmen Mannucci, Fabrizio Calapai   +13 more
core   +1 more source