Safety and efficacy of long-term use of sodium oxybate for narcolepsy with cataplexy in routine clinical practice [PDF]
Sleep Medicine, 2017 Background Sodium oxybate is licensed in Europe for the treatment of narcolepsy with cataplexy in adults. The aim of this study was to assess the efficacy and safety of sodium oxybate in clinical practice in patients with narcolepsy and cataplexy ...
D'Ancona, Grainne +11 more
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Sodium Oxybate: Practical Considerations and Patient Perspectives. [PDF]
CNS DrugsNarcolepsy is a rare, chronic sleep disorder with significant impacts on the quality of life of people affected by the disorder. People with narcolepsy (PWN) are a diverse patient population with evolving symptoms, comorbidities, and perspectives. As PWN
Lavender M, Martin C, Anderson D.
europepmc +2 more sources
Mayo Clinic ProceedingsOBJECTIVE To compare intermediate-term risk of new-onset hypertension between normotensive patients with narcolepsy initiating sodium oxybate (SXB cohort) and those not initiating sodium oxybate (control cohort). PATIENTS AND METHODS This retrospective
Rami H. Ben-Joseph +10 more
semanticscholar +3 more sources
Improvements in daytime sleepiness and disrupted nighttime sleep with once-nightly sodium oxybate in people with narcolepsy type 1 and type 2: a plain language summary [PDF]
Journal of Comparative Effectiveness ResearchWhat is this summary about? This is a plain language summary of a published article in the journal Sleep. Narcolepsy is a sleep condition that has 2 different subtypes: narcolepsy type 1 and narcolepsy type 2. These are called NT1 and NT2 for short.
Yves Dauvilliers +6 more
doaj +2 more sources
Effects of High- Versus Low-Sodium Oxybate on Blood Pressure in Patients With Narcolepsy. [PDF]
HypertensionBACKGROUND: People with narcolepsy are at increased risk for hypertension and cardiovascular disease; excessive sodium intake is linked to both. METHODS: We studied patients with narcolepsy and office systolic blood pressures (BPs) of 130 to 155 mm Hg ...
White WB +11 more
europepmc +2 more sources
Can Sodium Oxybate Mitigate the Symptoms of Schizophrenia? [PDF]
Curr NeuropharmacolSchizophrenia remains a therapeutic challenge. For much of its long history, the physiological basis of its symptoms and clinical presentation remained elusive.
Mamelak M.
europepmc +2 more sources
Efficacy of Once-Nightly Sodium Oxybate in Patients with Narcolepsy: Post Hoc Analyses of Sensitivity, Effect Size, and Numbers Needed to Treat from the Phase 3 REST-ON Trial. [PDF]
CNS DrugsOnce-nightly sodium oxybate (ON-SXB; LUMRYZ™; FT218) treatment significantly improved the coprimary endpoints of mean sleep latency on the Maintenance of Wakefulness Test (MWT), Clinical Global Impression of Improvement (CGI-I) rating, and number of ...
Roth T +3 more
europepmc +2 more sources
Neurology and Therapy, 2023 Narcolepsy is associated with disrupted nighttime sleep (DNS). Sodium oxybate (SXB; Xyrem®), administered twice nightly, is indicated for the treatment of cataplexy and excessive daytime sleepiness in patients 7 years or older with narcolepsy.
Russell Rosenberg +5 more
doaj +1 more source
Assessing Early Efficacy After Initiation of Once-Nightly Sodium Oxybate (ON-SXB; FT218) in Participants with Narcolepsy Type 1 or 2: A Post Hoc Analysis from the Phase 3 REST-ON Trial. [PDF]
CNS DrugsOnce-nightly sodium oxybate (LUMRYZ™; ON-SXB; FT218) significantly improved narcolepsy symptoms in the phase 3 REST-ON trial. The objective of this post hoc analysis was to investigate the early efficacy of ON-SXB at weeks 1 (4.5-g dose) and 2 (6-g dose).
Krahn L +4 more
europepmc +2 more sources
Sleep Dysfunction in Fibromyalgia and Therapeutic Approach Options [PDF]
, 2020 Fibromyalgia, characterised by persistent pain, sleep disturbance, fatigue and cognitive dysfunction, is a central sensitivity syndrome that also involves abnormality in peripheral generators and in the hypothalamic pituitary adrenal axis.
Lawson, Kim
core +1 more source