Results 31 to 40 of about 1,224,792 (212)

Sodium Oxybate (SMO) as Part of Agonist Opioid Treatment in Alcohol-Heroin-Addicted Patients. [PDF]

J Clin Med
Background: Alcohol use disorder in the context of heroin addiction presents a significant challenge for clinicians, particularly in selecting the most appropriate pharmacological treatment.
Maremmani AGI, Della Rocca F, Pacini M, Bacciardi S, Cimino S, Cerniglia L, Miccoli M, Maremmani I.   +7 more
europepmc   +2 more sources

Evidence of Accidental Dosing Errors with Immediate-Release Sodium Oxybate: Data from the US Food and Drug Administration Adverse Event Reporting System

Drugs - Real World Outcomes, 2023
Introduction Sodium oxybate has been approved by the US Food and Drug Administration (FDA) to treat narcolepsy for 20 years; however, the only available products have been immediate-release (IR) formulations given twice nightly—once at bedtime and a ...
Jennifer Gudeman, Danielle Burroughs
doaj   +1 more source

Pharmacokinetics, bioavailability, and bioequivalence of lower‐sodium oxybate in healthy participants in two open‐label, randomized, crossover studies

Clinical and Translational Science, 2021
American Academy of Sleep Medicine practice parameters designate sodium oxybate (SXB) as a standard of care for cataplexy, excessive daytime sleepiness (EDS), and disrupted night‐time sleep in narcolepsy.
Cuiping Chen, Jack Jenkins, Katie Zomorodi, Roman Skowronski   +3 more
doaj   +1 more source

Feasibility of following up gamma-hydroxybutyric acid concentrations in sodium oxybate (Xyrem®)-treated narcoleptic patients using dried blood spot sampling at home : an exploratory study [PDF]

, 2013
Background: Gamma-hydroxybutyric acid (GHB), well known as a party drug, especially in Europe, is also legally used (sodium oxybate, Xyrem (R)) to treat a rare sleep disorder, narcolepsy with cataplexy.
Hertegonne, Katrien, Ingels, Ann-Sofie, Lambert, Willy, Stove, Christophe   +3 more
core   +1 more source

Determination of gamma-hydroxybutyric acid in dried blood spots using a simple GC-MS method with direct 'on spot' derivatization [PDF]

, 2010
The objective of this study was the development of an accurate and sensitive method for the determination of gamma-hydroxybutyric acid (GHB) in dried whole blood samples using a GC-MS method.
Ingels, Ann-Sofie, Lambert, Willy, Stove, Christophe   +2 more
core   +1 more source

Current treatments to counter sleep dysfunction as a pathogenic stimulus of fibromyalgia [PDF]

, 2016
Fibromyalgia is characterized by chronic widespread pain, fatigue and nonrestorative sleep. Polysomnography showed reduced short-wave sleep and abnormal alpha rhythms during nonrapid eye movement sleep in patients with fibromyalgia.
Choy, Ernest H.
core   +2 more sources

Efficacy of modified atkins ketogenic diet in chronic cluster headache. An open-label, single-arm, clinical trial [PDF]

, 2018
Introduction: Drug-resistant cluster headache (CH) is still an open clinical challenge. Recently, our group observed the clinical efficacy of a ketogenic diet (KD), usually adopted to treat drug-resistant epilepsies, on migraine.
Cherubino Di Lorenzo, Davide Di Lenola, Francesco Pierelli, Francesco Pierelli, Gianluca Coppola, Giorgio Di Lorenzo, Giulio Sirianni, Mariano Serrao, Maurizio Evangelista, Paolo Rossi   +9 more
core   +3 more sources

Narcolepsy treatment: from exorcism and bloodletting to modern therapy with histamine receptor inverse agonists

Neurologijos seminarai, 2020
In this review article, we present the treatment of narcolepsy since ancient times when patients experiencing the phenomenon of incubus (today understood as sleep paralysis with hypnagogic or hypnopompic hallucinations) were “cured” during the sessions ...
E. Sakalauskaitė-Juodeikienė, R. Masaitienė   +1 more
doaj   +1 more source

Physician experiences with and perceptions of risk evaluation and mitigation strategy programs with elements to assure safe use.

PLoS ONE, 2023
PurposeThe US Food and Drug Administration (FDA) Amendments Act of 2007 authorized the FDA to require risk evaluation and mitigation strategy (REMS) programs for drugs with important safety concerns.
Ameet Sarpatwari, Beatrice L Brown, Sarah A McGraw, Sara Z Dejene, Abdurrahman Abdurrob, Aaron S Kesselheim   +5 more
doaj   +1 more source

Prescribing sodium oxybate for narcolepsy: Demanding that a patient's need is "exceptional" is irrational and should be abandoned [PDF]

, 2016
PublishedEditorialJournalEditorial
Zaiwalla, Z, Zeman, A
core   +1 more source