Results 61 to 70 of about 626 (142)

The role of sodium oxybate in idiopathic hypersomnia: A case report showing improvement of excessive daytime sleepiness and reduced symptoms

, 2023
Our aim is to report the clinical profile and outcome of patients diagnosed with idiopathic hypersomnia (IH). Idiopathic hypersomnolence is a complex, debilitating, and uncommon sleep disorder manifested mainly by chronic excessive daytime ...
Patel, Palak, Kharel, Kirti K, Akhtar, Jamshaid, Vera Ricaurte, Michael, Sundaram, Akshay, Kagzi, Mohammad   +5 more
core   +1 more source

Narcolepsy: Pathophysiology, Diagnosis, Management, and Future Directions, a Narrative Review

Brain and Behavior, Volume 15, Issue 12, December 2025.
This visual summary outlines the pathophysiology of narcolepsy, driven by hypocretin loss, and details its clinical diagnosis, current management strategies, and the shift toward future disease‐modifying therapies like orexin agonists and immunomodulation.
Natasha Elaine Hastings, Khalil El Abdi, Fazeela Bibi, Bilal Aslam, Milka Rosario Nuñez, Muhammad Tahla Rehman Sherani, Sujeet Shadmani, Umama Alam, Vohra Maham Hassan, Hoor‐e‐Ainaa, Hania Imran, James Hanna, Said Hamid Sadat   +12 more
wiley   +1 more source

Prolonged Detection of GHB Intake in Urine: Are We Finally There?

Drug Testing and Analysis, Volume 17, Issue 12, Page 2429-2446, December 2025.
In a randomised placebo‐controlled trial with 30 volunteers, urinary LC‐MS/MS analysis demonstrated that a tentative GHB‐pentose conjugate remained elevated in urine up to 72 h post‐administration. This biomarker showed clear distinction from placebo and may offer extended detection compared to GHB itself, representing a significant step forward in ...
Kathrine B. Faldborg, Jørgen B. Hasselstrøm, Thomas Kraemer, Charlotte U. Andersen, Andrea E. Steuer   +4 more
wiley   +1 more source

Treatment of Neurogenic Voice Disorders

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 11, Issue 4, Page 541-547, December 2025.
ABSTRACT This overview serves as a foundational resource for clinicians caring for neurologically complex patients presenting with voice complaints. Neurogenic voice disorders are diverse in their clinical presentations and therapeutic approaches. A thorough medical history, including family history, detailed laryngeal examination, voice assessments ...
Mausumi Syamal
wiley   +1 more source

Effect of sodium oxybate on disrupted nighttime sleep in patients with narcolepsy

, 2017
This post hoc analysis evaluated the dose-related effects of sodium oxybate on sleep continuity and nocturnal sleep quality in patients with narcolepsy-cataplexy.
Dauvilliers, Yves, Dynin, Efim, Guinta, Diane, Alvarez-Horine, Sarah, Roth, Thomas, Black, Jed   +5 more
core  

Narcolepsy: a machine learning bibliometric analysis (1996–2024)

Frontiers in Neurology
BackgroundNarcolepsy is a rare neurological cause of chronic sleepiness. This study aimed to better understand global narcolepsy through bibliometric analysis.MethodsArticles and reviews on narcolepsy were sourced from the Web of Science Core Collection.
Minheng Zhang, Xiaodong Hu, Haiyan Wu, Haixia Fan   +3 more
doaj   +1 more source

Alcohol-responsive Action Myoclonus of the Leg in Prostate Cancer: A Novel Paraneoplastic Syndrome?

Tremor and Other Hyperkinetic Movements, 2015
Background: Paraneoplastic movement disorders in prostate cancer are rare, and to our knowledge paraneoplastic myoclonus has not previously been reported.
Pichet Termsarasab, Steven J. Frucht
doaj   +1 more source

Calcium, Magnesium, Potassium and Sodium Oxybates (Xywav®) in Sleep Disorders: A Profile of Its Use

, 2022
Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest Young-A Heo is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts ...
Young-A Heo (5060039)
core   +1 more source

Dosing Optimization of Low-Sodium Oxybate in Narcolepsy and Idiopathic Hypersomnia in Adults: Consensus Recommendations

Neurology and Therapy
Introduction Low-sodium oxybate (LXB) is approved for treatment of narcolepsy in patients aged 7 years and older and treatment of idiopathic hypersomnia in adults. LXB contains the same active moiety with 92% less sodium than sodium oxybate (SXB). As the
Anne Marie Morse, Richard K. Bogan, Asim Roy, Michael J. Thorpy   +3 more
doaj   +1 more source

Plasma total ghrelin and leptin levels in human narcolepsy and matched healthy controls: Basal concentrations and response to sodium oxybate

, 2013
Contains fulltext : 149653.pdf (Publisher’s version ) (Closed access)STUDY OBJECTIVES: Narcolepsy is caused by a selective loss of hypocretin neurons and is associated with obesity. Ghrelin and leptin interact with hypocretin neurons to
Donjacour, CEHM Claire, Pijl, H., Donjacour, C.E., Roelfsema, F., Overeem, S Sebastiaan, Lammers, Gert Jan Gert, Roelfsema, Ferdinand, Frolich, M., Aziz, N Ahmad, Frölich, Marijke, Pardi, Daniel, Lammers, G.J., Aziz, N.A., Pijl, Hanno, Donjacour, C.E.H.M., Overeem, S., Pardi, D.   +16 more
core   +1 more source