Results 131 to 140 of about 4,987 (175)

Thermal investigation on polymorphism in sodium saccharine

Journal of Thermal Analysis and Calorimetry, 2014
The thermal behavior of sodium saccharin polymorphic forms was investigated using thermogravimetry and differential scanning calorimetry, while structural changes during the dehydration processes were monitored by X-ray powder diffraction. In solid state, sodium saccharine may exhibit three forms: anhydrate, 2/3 hydrate (triclinic), and 15/8 hydrate ...
Deyber Arley Vargas Medina, Ana Paula Garcia Ferreira, Eder Tadeu Gomes Cavalheiro   +2 more
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Study of sodium saccharin co-carcinogenicity in the rat

Food and Chemical Toxicology, 1994
A co-carcinogenicity experiment was conducted with female Sprague-Dawley rats in which the effects of short-term sodium saccharin dosing and initiation with a direct-acting carcinogen were examined in the urinary bladder. All initiated animals were administered 0.5 mg N-methyl-N-nitrosourea (MNU) by instillation into the bladder at 8 wk of age.
R W, West, W G, Sheldon, D W, Gaylor, R R, Allen, F F, Kadlubar   +4 more
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Sodium Cyclamate, Saccharin and Food Efficiency

Nature, 1969
FOLLOWING experiments with 0.43 per cent sodium cyclamate in rat's food1 in which rats consuming cyclamate had a better food efficiency than the controls, I performed two further experiments using two basic rations; saccharin was introduced, and both sweetening agents were given in varying amounts to weanling Wistar strain albino rats of both sexes ...
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The inhibition of urease and proteases by sodium saccharin

Cancer Letters, 1982
Sodium saccharin, at concentrations similar to those in the urine of rats fed 1-5% sodium saccharin in their diet, markedly inhibited urease, and 3 proteases in vitro and sodium ion did not appear to play a role in enzyme inhibition. These observations suggest that enzyme inhibition of any of a large number of enzymes may play a role in the ...
E, Lok, F, Iverson, D B, Clayson
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Antimutagenesis in Yeast by Sodium Chloride, Potassium Chloride, and Sodium Saccharin

1990
Aqueous salt solutions containing NaCl, KCl, MgCl2, Na2SO4, CaCl2, NH4Cl, or sodium saccharin are mutagenic in yeast when logarithmic growth of cells is interrupted by exposure to a 0.5-2.0 M salt solution. Stationary-phase cells are not mutated by this treatment.
K R, Parker, R C, von Borstel
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Alterations in the rat kidney associated with sodium saccharin feeding

Toxicology Letters, 1982
Sodium saccharin has previously been demonstrated to induce hyperplasia and tumors of the urothelium of the rat urinary bladder. It was fed as 5% of the diet to male F344 rats for 2 years. In the present experiment, mild simple hyperplasia of the urinary bladder epithelium was again frequently observed, and a marked nodular and papillary hyperplasia of
G, Murasaki, R E, Greenfield, S M, Cohen
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Subacute toxicity studies with sodium saccharin and two hydrolytic derivatives

Toxicology, 1976
The subacute toxicity of sodium saccharin and 2 hydrolytic derivatives, o-sulfamoylbenzoic acid (Compound I) and ammonium o-carboxybenzene sulfonate (Compound II) was evaluated by feeding each of the compounds alone at a dietary level of 20 000 ppm to both beagle dogs and albino rats. Additionally, groups of dogs and rats were fed combinations of the 3
G L, Kennedy, O E, Fancher, J C, Calandra   +2 more
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Production of Urinary Bladder Carcinomas in Mice by Sodium Saccharin

Science, 1970
Pellets weighing 20 to 24 milligrams and containing 20 percent sodium saccharin suspended in cholesterol were surgically implanted into the urinary bladder lumens of female Swiss mice (60 to 90 days old) under ether anesthesia. Incidences of mouse bladder carcinomas in animals exposed to these pellets were 47 and 52 percent as compared with incidences ...
G T, Bryan, E, Ertürk, O, Yoshida
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Sodium Saccharin Inhibits Adenylyl Cyclase Activity in Non-Taste Cells

Cellular Signalling, 1997
We have studied the in vitro effect of sodium saccharin (NaSacch) on the rat adipocyte adenylyl cyclase complex. NaSacch (2.5-50 mM) inhibited significantly in a dose-dependent manner basal and isoproterenol-stimulated cAMP accumulation on isolated rat adipocytes.
K, Dib, F, Wrisez, A, el Jamali, B, Lambert, C, Correze   +4 more
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In vitro cytotoxicity of the sodium, potassium and calcium salts of saccharin, sodium ascorbate, sodium citrate and sodium chloride

Toxicology in Vitro, 1989
The in vitro effects of saccharin were evaluated in a transformed rat-bladder epithelial cell line. AY-27 cells were seeded in a 35-mm tissue culture well and incubated for 24 hr with saccharin or other test compounds dissolved in the media. The cytotoxic effects of saccharin were dependent on the salt form tested.
E M, Garland, J M, Parr, D S, Williamson, S M, Cohen   +3 more
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