Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun +27 more
wiley +1 more source
From Clogging Mitigation to Clogging Acceleration: Particle Deposition Under Oscillatory Flow in Microfluidic Porous Media. [PDF]
Okaybi W, Roman S, Soulaine C.
europepmc +1 more source
Breaking the Toughness‐Stretchability Trade‐Off in Hydrogels with Dynamic Hydrogen Bonding
A novel nanocomposite hydrogel architecture overcomes the inherent conflict between toughness and stretchability by integrating uniformly dispersed aminopropyl‐hybrid‐phyllosilicate nanosheets within a polyacrylamide matrix. This design leverages a dynamic hydrogen‐bonding network to facilitate efficient energy dissipation and self‐recovery.
Yining Gao +3 more
wiley +1 more source
Effects of intra-articular injection of dimethyl itaconate combined with systemic vancomycin on periprosthetic joint infection in rats. [PDF]
Dai T, Ma C, Zhang F, Wen Y, Chen L.
europepmc +1 more source
Highly Flexible and Conformable ZnO/FeGa Magnetoelectric Heterostructures for Skin wound Healing
The magnetic field‐induced electric field generated by a highly flexile ZnO(piezoelectric)/FeGa(magnetostrictive) magnetoelectric heterostructure embedded in the low Young's modulus elastomer PDMS has been used to stimulate the wound healing processes.
Filippos Perdikos +17 more
wiley +1 more source
Halving global road traffic deaths through targeted mitigation practices by 2050. [PDF]
Zou S, Lv F, Qian Y, Han C, Zhu J.
europepmc +1 more source
Sustainable Materials Design With Multi‐Modal Artificial Intelligence
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu +8 more
wiley +1 more source
Correction to "Persistent <i>Burkholderia cepacia</i> Bacteremia in Reconstructive Surgery: Resistance to Ceftazidime/Avibactam and Co-Trimoxazole With Risk of Infective Endocarditis-A Case Report". [PDF]
europepmc +1 more source
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley +1 more source

