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Programmable Microwaveable Chemistry in the Chemputer. [PDF]
Angew Chem Int Ed EnglZero J +5 more
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Synthesis of Trifluoromethylated Analogues of the Cyclic Lipopeptide Iturin A and Evaluation of their Antifungal Activity. [PDF]
ChempluschemKaramanis P +5 more
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Convergent solid-phase peptide synthesis
Tetrahedron, 1993The solid-phase synthesis, photolytic detachment from the solid support and purification in solution, of a fully-protected octapeptide containing a methionine residue (protected as the sulphoxide) is described. Protection of methionine in this manner avoids problems associated with the oxidation of this residue during the photolysis.
F, Albericio +2 more
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Journal of Macromolecular Science: Part A - Chemistry, 1976
Abstract The last two decades have been an era of rapid progress in peptide research. This era was begun by the work of Sanger on the amino acid sequence determination of insulin and by du Vigneaud on the structure determination and synthesis of oxytocin.
BRUCE W. ERICKSON, R.B. MERRIFIELD
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Abstract The last two decades have been an era of rapid progress in peptide research. This era was begun by the work of Sanger on the amino acid sequence determination of insulin and by du Vigneaud on the structure determination and synthesis of oxytocin.
BRUCE W. ERICKSON, R.B. MERRIFIELD
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Fmoc Solid-Phase Peptide Synthesis
2015Synthetic peptides are important as drugs and in research. Currently, the method of choice for producing these compounds is solid-phase peptide synthesis. In this nonspecialist review, we describe the scope and limitations of Fmoc solid-phase peptide synthesis. Furthermore, we provide a detailed protocol for Fmoc peptide synthesis.
Hansen, Paul Robert, Oddo, Alberto
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Solid‐phase peptide synthesis on proteins
International Journal of Peptide and Protein Research, 1993A new method for solid‐phase peptide synthesis in which a protein is used as the solid support has been developed. Two aspects of the method have been demonstrated. The peptides H‐Phe‐Leu‐Glu‐Glu‐Val‐OH (1) and H‐Leu‐Leu‐Ala‐Glj‐Val‐OH (2), respectively, were synthesized on the amino groups of BSA via a cleaveable linker, using the Fmoc group ...
Hansen, Paul Robert +2 more
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Automated Solid-Phase Peptide Synthesis
2019The development of solid-phase peptide synthesis by Bruce Merrifield paved the way for a synthesis carried out by machines. Automated peptide synthesis is a fast and convenient way of synthesizing many peptides simultaneously. This chapter tries to give a general guidance for the development of synthesis protocols for the peptide synthesizer.
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Solid-Phase Synthesis of Fullerene-peptides
Journal of the American Chemical Society, 2002The solid-phase synthesis of peptides (SPPS) containing [60]fullerene-functionalized amino acids is reported. A new amino acid, fulleropyrrolidino-glutamic acid (Fgu), is used for the SPPS of a series of analogues of different length based on the natural Leu(5)-Enkephalin and on cationic antimicrobial peptides.
PANTAROTTO, DAVIDE +7 more
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Solid phase synthesis of peptide-selenoesters
Bioorganic & Medicinal Chemistry, 2013The synthesis of proteins by native chemical ligation greatly enhances the application of chemistry to complex molecules such as proteins. The essential building blocks for this approach traditionally have been peptide-thioester segments that are linked chemoselectively in consecutive reactions.
Ghassemian, Artin +3 more
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