Results 251 to 260 of about 132,649 (294)
Some of the next articles are maybe not open access.
Solid-Phase Peptide Synthesis: An Introduction
2013This chapter provides an introduction to and overview of peptide chemistry with a focus on solid-phase peptide synthesis. The background, the most common reagents, and some mechanisms are presented. This chapter also points to the different chapters and puts them into perspective.
openaire +3 more sources
Microwave heating in solid-phase peptide synthesis
Chem. Soc. Rev., 2012The highly refined organic chemistry in solid-phase synthesis has made it the method of choice not only to assemble peptides but also small proteins - mainly on a laboratory scale but increasingly also on an industrial scale. While conductive heating occasionally has been applied to peptide synthesis, precise microwave irradiation to heat the reaction ...
Pedersen, Søren Ljungberg +3 more
openaire +3 more sources
Automated Synthesis of Solid Phase Bound Peptides
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Heinrich Gausepohl, Christian Behn
openaire +1 more source
Solid‐Phase synthesis of peptide nucleic acids
Journal of Peptide Science, 1995AbstractPeptide nucleic acids (PNA) were synthesized by a modified Merrifield method using several improvements. Activation by O‐(benzotriazol‐1‐yl)‐1,1,3,3‐tetramethyluronium hexafluorophosphate in combination with in situ neutralization of the resin allowed efficient coupling of all four Boc‐protected PNA monomers within 30 min.
Christensen, Leif +10 more
openaire +3 more sources
Active esters in solid-phase peptide synthesis
Journal of Protein Chemistry, 1989Incorporation of single amino acid residues into peptide chains built on insoluble polymeric supports a priori appeared promising: the use of isolated, well defined (and potentially commercially available) reactive intermediates were expected to reduce the extent of undesired side reactions.
M, Bodanszky, M A, Bednarek
openaire +2 more sources
Solid‐phase synthesis of peptide‐4‐nitroanilides
International Journal of Peptide and Protein Research, 1996A wide variety of Glu/Asp and Gln containing peptide‐4‐nitroanilides and other chromogenic peptidyl‐arylamides could be quickly synthesized by a Fmoc‐based solid‐phase synthesis strategy employing the side‐chain carboxyl groups for transient anchoring to the resin. Suitable synthons for this method, Fmoc‐Glu‐NH‐Np and Fmoc‐Asp‐NH‐Np.
A, Kaspari +2 more
openaire +2 more sources
1994
Abstract The chemical synthesis of oxytocin, with biological activity indistinguishable from that of the native hormone, by du Vigneaud and co-workers in 1953, represents a landmark in the application of synthetic peptides to the study of biology (1).
openaire +1 more source
Abstract The chemical synthesis of oxytocin, with biological activity indistinguishable from that of the native hormone, by du Vigneaud and co-workers in 1953, represents a landmark in the application of synthetic peptides to the study of biology (1).
openaire +1 more source
1988
By the conventional methods of organic synthesis, preparation of peptides containing more than just a few amino acids is an arduous task. Introduction of blocking groups, coupling reactions and deprotection steps entail a large number of operations, such as washing the reaction mixtures neutral after coupling, precipitation or crystallization of ...
openaire +1 more source
By the conventional methods of organic synthesis, preparation of peptides containing more than just a few amino acids is an arduous task. Introduction of blocking groups, coupling reactions and deprotection steps entail a large number of operations, such as washing the reaction mixtures neutral after coupling, precipitation or crystallization of ...
openaire +1 more source