Results 241 to 250 of about 132,649 (294)
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Solid-Phase Synthesis of Lipidated Peptides
Journal of the American Chemical Society, 2002Characteristic partial structures of lipidated proteins embodying different lipid groups as well as additional fluorescent tags or a maleimide for coupling to proteins can be synthesized readily by means of a new solid-phase technique employing the oxidative cleavage of the hydrazide linker as well as on-resin farnesylation and palmitoylation after ...
Ludolph, B., Eisele, F., Waldmann, H.
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Solid phase synthesis of peptide-selenoesters
Bioorganic & Medicinal Chemistry, 2013The synthesis of proteins by native chemical ligation greatly enhances the application of chemistry to complex molecules such as proteins. The essential building blocks for this approach traditionally have been peptide-thioester segments that are linked chemoselectively in consecutive reactions.
Ghassemian, Artin +3 more
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Convergent solid-phase peptide synthesis
Tetrahedron, 1993The solid-phase synthesis, photolytic detachment from the solid support and purification in solution, of a fully-protected octapeptide containing a methionine residue (protected as the sulphoxide) is described. Protection of methionine in this manner avoids problems associated with the oxidation of this residue during the photolysis.
F, Albericio +2 more
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Apparatus for Solid-Phase Peptide Synthesis
Science, 1967The apparatus, designed for solid-phase peptide synthesis, consists of a round-bottom flask, rocked on a wrist-shaker, and fitted with a special dropping funnel and a fritted filter disc embedded within the flask. The dropping funnel is designed to wash down the polymer adhering to the neck of the flask.
M C, Khosla, R R, Smeby, F M, Bumpus
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Solid‐phase peptide synthesis on proteins
International Journal of Peptide and Protein Research, 1993A new method for solid‐phase peptide synthesis in which a protein is used as the solid support has been developed. Two aspects of the method have been demonstrated. The peptides H‐Phe‐Leu‐Glu‐Glu‐Val‐OH (1) and H‐Leu‐Leu‐Ala‐Glj‐Val‐OH (2), respectively, were synthesized on the amino groups of BSA via a cleaveable linker, using the Fmoc group ...
Hansen, Paul Robert +2 more
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Journal of Macromolecular Science: Part A - Chemistry, 1976
Abstract The last two decades have been an era of rapid progress in peptide research. This era was begun by the work of Sanger on the amino acid sequence determination of insulin and by du Vigneaud on the structure determination and synthesis of oxytocin.
BRUCE W. ERICKSON, R.B. MERRIFIELD
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Abstract The last two decades have been an era of rapid progress in peptide research. This era was begun by the work of Sanger on the amino acid sequence determination of insulin and by du Vigneaud on the structure determination and synthesis of oxytocin.
BRUCE W. ERICKSON, R.B. MERRIFIELD
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Solid-Phase Synthesis of Fullerene-peptides
Journal of the American Chemical Society, 2002The solid-phase synthesis of peptides (SPPS) containing [60]fullerene-functionalized amino acids is reported. A new amino acid, fulleropyrrolidino-glutamic acid (Fgu), is used for the SPPS of a series of analogues of different length based on the natural Leu(5)-Enkephalin and on cationic antimicrobial peptides.
PANTAROTTO, DAVIDE +7 more
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Solid‐Phase Synthesis of DOTA–Peptides
Chemistry – A European Journal, 2004AbstractA general synthetic route to two DOTA‐linked N‐Fmoc amino acids (DOTA‐F and DOTA‐K) is described that allows insertion of DOTA at any endo‐position within a peptide sequence. Three model pentapeptides were prepared to test the general utility of these derivatives in solid‐phase peptide synthesis.
Luis M, De León-Rodriguez +3 more
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Analytical Methods for Solid Phase Peptide Synthesis
Current Organic Chemistry, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
SABATINO, GIUSEPPINA +3 more
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Automated Solid-Phase Peptide Synthesis
2019The development of solid-phase peptide synthesis by Bruce Merrifield paved the way for a synthesis carried out by machines. Automated peptide synthesis is a fast and convenient way of synthesizing many peptides simultaneously. This chapter tries to give a general guidance for the development of synthesis protocols for the peptide synthesizer.
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