Results 111 to 120 of about 327,171 (380)

Multifunctional Microstructured Surfaces by Microcontact Printing of Reactive Microgels

Advanced Functional Materials, EarlyView.
Reactive poly(N‐vinylcaprolactam‐co‐glycidyl methacrylate) microgels are used as functional inks to create surface‐grafted arrays on glass via microcontact printing. The patterns (10–50 µm widths and spacings) enable stable binding and post‐functionalization with dyes and peptides.
Inga Litzen, Alexander Töpel, Martin Zenke, Antonio Sechi, Andrij Pich   +4 more
wiley   +1 more source

Optimized Solid Phase-Assisted Synthesis of Dendrons Applicable as Scaffolds for Radiolabeled Bioactive Multivalent Compounds Intended for Molecular Imaging

Molecules, 2014
Dendritic structures, being highly homogeneous and symmetric, represent ideal scaffolds for the multimerization of bioactive molecules and thus enable the synthesis of compounds of high valency which are e.g., applicable in radiolabeled form as ...
Gabriel Fischer, Björn Wängler, Carmen Wängler   +2 more
doaj   +1 more source

Novel sulfur and selenium containing bis-α-amino acids from 4-hydroxyproline [PDF]

, 2010
The synthesis of new substituted prolines carrying at C-4 a second α-amino acid residue is reported. The amino acid, l-cysteine or l-selenocysteine, is linked to the proline ring through the sulfur or the selenium atom, respectively.
CAPUTO, ROMUALDO, D. MASTROIANNI, DELLA GRECA, MARINA, I. de PAOLA, LONGOBARDO, LUIGI   +4 more
core   +1 more source

Tunable and Recyclable Piezoelectric Biomaterials via Ion‐Directed Guanine‐Quadruplex Assembly

Advanced Functional Materials, EarlyView.
Guanine‐quadruplex (GQ) assemblies, formed via ion‐mediated self‐assembly of amphiphilic guanine derivatives, are introduced as tunable and recyclable piezoelectric biomaterials. Distinct alkali ions induce unique dipole configurations and piezoelectric outputs, with K⁺ yielding the highest performance.
Seungho Lee, Sangyun Na, Yumi Cho, Gaeun Park, Seung Hak Oh, Jaejun Kim, Byoung‐Ki Cho, Sang Kyu Kwak, Ja‐Hyoung Ryu, Hyunhyub Ko   +9 more
wiley   +1 more source

Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy [PDF]

, 2013
Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer ...
Chan, Kiat-Hwa, Gopalan, Began, Hauser, Charlotte A. E., Joshi, Mangesh, Lakshmanan, Anupama, Lam, Dang Hoang, Mishra, Archana, Reithofer, Michael R., Wang, Shu   +8 more
core   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Reconfigurable Magnetic Soft Microrobot for Acoustically Triggered Targeted Bacterial Sterilization

Advanced Functional Materials, EarlyView.
Reconfigurable magnetic soft microrobots integrate in situ‐grown piezoelectric zinc oxide nanorods that produce reactive oxygen species upon acoustic excitation. Combining magnetically guided transport with thermally induced planar reconfiguration, the microrobots achieve targeted delivery and enhanced bacterial sterilization through efficient on ...
Quan Gao, Fan Li, Jiajie Gao, Elric Zhang, Yingdong Su, Ni Qin, Hao Ye, Josep Puigmartí, Giuseppe Cantarella, Simone Schuerle, Jiang Wu, Bradley J. Nelson, Salvador Pané   +12 more
wiley   +1 more source

Perfluorophenyl Derivatives as Unsymmetrical Linkers for Solid Phase Conjugation

Frontiers in Chemistry, 2018
Linkers play major roles in conjugation chemistry toward the advancement of drug discovery. Two different series of fluorinated linkers were introduced to the backbone of a model peptide using solid phase peptide synthesis. These fluorinated linkers have
Saba Alapour, Anamika Sharma, Anamika Sharma, Beatriz G. de la Torre, Deresh Ramjugernath, Neil A. Koorbanally, Fernando Albericio, Fernando Albericio   +7 more
doaj   +1 more source

Laser‐Based Sculpturing of Embedded Ultrathin Metal‐Oxide Nanopores for Enhanced Biomolecular Sensing

Advanced Functional Materials, EarlyView.
Controlled laser‐drilling of embedded HfO2 membranes creates three layer nanopores with Gaussian‐shaped cavities sculptured in the supporting layers. These embedded solid‐state nanopores slow DNA translocation by 12‐fold compared to SiNx pores, enabling high‐resolution, label‐free detection of short DNAs, RNAs, and proteins.
Jostine Joby, Yulia Marom, Guocong Lin, Aleksandra Baron‐Wiechec, Amit Meller   +4 more
wiley   +1 more source

Bioinspired Bromination Enables Extensible, Strain‐Stiffening Resilin Peptide Scaffolds with Tunable Degradation

Advanced Functional Materials, EarlyView.
Bioinspired bromination of a resilin‐derived peptide enables the fabrication of electrospun nanofibrous scaffolds that uniquely combine strain‐stiffening elasticity, proteolytic stability, and antioxidant functionality. These brominated peptide–gelatin hybrids mimic the extensibility of natural elastomers, demonstrating tunable mechanical resilience ...
Elisa Marelli, Lorenzo Sori, Chiara Russo, Claudia Pigliacelli, Lorenza Draghi, Monica Soncini, Pierangelo Metrangolo   +6 more
wiley   +1 more source