Results 121 to 130 of about 327,171 (380)

Total chemical synthesis of a heterodimeric interchain Bis-Lactam-linked peptide: application to an analogue of human insulin-like peptide 3 [PDF]

, 2013
Nonreducible cystine isosteres represent important peptide design elements in that they can maintain a near-native tertiary conformation of the peptide while simultaneously extending the in vitro and in vivo half-life of the biomolecule.
Gardiner, J., Hossain, M., Karas, J., Scanlon, D., Separovic, F., Shabanpoor, F., Wade, J.   +6 more
core   +3 more sources

4D Mapping of ZIF Biocomposites for High Protein Loading and Tunable Release Profiles

Advanced Functional Materials, EarlyView.
Systematic four‐dimensional mapping of zeolitic imidazolate framework biocomposites reveals how precursor ratios, total concentration, and washing define crystalline phase, protein loading, and release kinetics. This comprehensive study identifies conditions yielding record loading (∼85%) and precise phase–property correlations.
Michael R. Hafner, Francesco Carraro, Behnaz Abbasgholi‐NA, Simone Dal Zilio, Max Schmallegger, Helmar Wiltsche, Lingcong Ge, Michael R. Reithofer, Efwita Astria, Laura Villanova, Heinz Amenitsch, Christian Doonan, Paolo Falcaro   +12 more
wiley   +1 more source

A practical synthesis of the 13C/15N-labelled tripeptide N-formyl-Met-Leu-Phe, useful as a reference in solid-state NMR spectroscopy

Beilstein Journal of Organic Chemistry, 2008
A mild synthetic method for N-formyl-Met-Leu-Phe-OH (1) is described. After Fmoc solid phase peptide synthesis, on-bead formylation and HPLC purification, more than 30 mg of the fully 13C/15N-labelled tripeptide 1 could be isolated in a typical batch ...
Sven T. Breitung, Jakob J. Lopez, Gerd Dürner, Clemens Glaubitz, Michael W. Göbel, Marcel Suhartono   +5 more
doaj   +1 more source

Synthesis of N-peptide-6-amino-D-luciferin Conjugates

Frontiers in Chemistry, 2018
A general strategy for the synthesis of N-peptide-6-amino-D-luciferin conjugates has been developed. The applicability of the strategy was demonstrated with the preparation of a known substrate, N-Z-Asp-Glu-Val-Asp-6-amino-D-luciferin (N-Z-DEVD-aLuc).
Anita K. Kovács, Anita K. Kovács, Péter Hegyes, Gábor J. Szebeni, Gábor J. Szebeni, Lajos I. Nagy, László G. Puskás, László G. Puskás, Gábor K. Tóth   +8 more
doaj   +1 more source

Continual reproduction of self-assembling oligotriazole peptide nanomaterials. [PDF]

, 2017
Autocatalytic chemical reactions, whereby a molecule is able to catalyze its own formation from a set of precursors, mimic nature's ability to generate identical copies of relevant biomolecules, and are thought to have been crucial for the origin of life.
Brea, Roberto J, Devaraj, Neal K
core   +2 more sources

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

Microwave Assisted Synthesis of Py-Im Polyamides [PDF]

, 2012
Microwave synthesis was utilized to rapidly build Py-Im polyamides in high yields and purity using Boc-protection chemistry on Kaiser oxime resin. A representative polyamide targeting the 5′-WGWWCW-3′ (W = A or T) subset of the consensus Androgen and ...
Bacsa B., Baird E. E., Bando T., Baptiste B., Chenoweth D. M., Chenoweth D. M., Chenoweth D. M., Choi J. S., Dale J. A., DeGrado W. F., Dervan P. B., Dervan P. B., Dose C., Edelson B. S., Farnham P. J., Harki D. A., Harris D., James W. Puckett, Joshua T. Green, Kappe C. O., Krutzik P. O., König B., Lai Y.-M., Murray J. K., Muzikar K. A., Nickols N. G., Olenyuk B. Z., Olivos H. J., Palasek S. A., Pelton J. G., Peter B. Dervan, Raskatov J. A., Sinyakov A. N., Su W., Turner J. M., Wade W. S., White S., Wurtz N. R., Xiao J. H.   +38 more
core   +2 more sources

Microplastics from Wearable Bioelectronic Devices: Sources, Risks, and Sustainable Solutions

Advanced Functional Materials, EarlyView.
Bioelectronic devices (e.g., e‐skins) heavily rely on polymers that at the end of their life cycle will generate microplastics. For research, a holistic approach to viewing the full impact of such devices cannot be overlooked. The potential for devices as sources for microplastics is raised, with mitigation strategies surrounding polysaccharide and ...
Conor S. Boland
wiley   +1 more source

Synthesis method of asymmetric gold particles. [PDF]

, 2017
Asymmetric particles can exhibit unique properties. However, reported synthesis methods for asymmetric particles hinder their application because these methods have a limited scale and lack the ability to afford particles of varied shapes.
Hahm, Eunil, Jun, Bong-Hyun, Lee, Luke, Murata, Michael   +3 more
core   +1 more source

Generating Cell Surface Nucleated Hydrogels with an Artificial Membrane‐Binding Transglutaminase

Advanced Functional Materials, EarlyView.
Cell‐based therapies require advanced strategies to enhance cell delivery and bioactivity. Cell membrane engineering offers an avenue to impart new functions to delivered cells to boost their viability and function. Here, an artificial membrane‐binding transglutaminase is generated and biophysically characterized.
Rosalia Cuahtecontzi Delint, Tao Li, Kapil D. Patel, Will H. Zhang, Ben M. Carter, Graham J. Day, Adam W. Perriman   +6 more
wiley   +1 more source