Results 261 to 270 of about 199,414 (326)
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Making Solid-Phase Peptide Synthesis Greener: A Review of the Literature.
Chemistry - An Asian Journal, 2019To date, the synthesis of peptides is concurrent with the production of enormous amounts of toxic waste. DMF, CH2 Cl2 , and NMP are three of the most toxic organic solvents used in chemical synthesis and are the most common solvents used for peptide ...
Kyriakos G Varnava, V. Sarojini
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Solid‐Phase Synthesis of DOTA–Peptides
Chemistry – A European Journal, 2004AbstractA general synthetic route to two DOTA‐linked N‐Fmoc amino acids (DOTA‐F and DOTA‐K) is described that allows insertion of DOTA at any endo‐position within a peptide sequence. Three model pentapeptides were prepared to test the general utility of these derivatives in solid‐phase peptide synthesis.
Luis M, De León-Rodriguez +3 more
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Green Transformation of Solid-Phase Peptide Synthesis
ACS Sustainable Chemistry and Engineering, 2019Peptides play key roles in medicinal chemistry, being found in therapeutics and diagnostic agents, among others. Furthermore, their synthetic protocols have also been optimized for other fields such as the solid-phase organic synthesis of other organic ...
Yahya E. Jad +4 more
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Analytical Methods for Solid Phase Peptide Synthesis
Current Organic Chemistry, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
SABATINO, GIUSEPPINA +3 more
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Troubleshooting When Using γ-Valerolactone (GVL) in Green Solid-Phase Peptide Synthesis
Organic Process Research & Development, 2019The synthesis of peptides for both research and API production is conveniently carried out using the solid-phase strategy. However, the main drawback of this approach is the large amounts of hazardous solvents required.
A. Kumar +6 more
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Automated Solid-Phase Peptide Synthesis
2019The development of solid-phase peptide synthesis by Bruce Merrifield paved the way for a synthesis carried out by machines. Automated peptide synthesis is a fast and convenient way of synthesizing many peptides simultaneously. This chapter tries to give a general guidance for the development of synthesis protocols for the peptide synthesizer.
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Solid-Phase Peptide Synthesis: An Introduction
2013This chapter provides an introduction to and overview of peptide chemistry with a focus on solid-phase peptide synthesis. The background, the most common reagents, and some mechanisms are presented. This chapter also points to the different chapters and puts them into perspective.
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Microwave heating in solid-phase peptide synthesis
Chem. Soc. Rev., 2012The highly refined organic chemistry in solid-phase synthesis has made it the method of choice not only to assemble peptides but also small proteins - mainly on a laboratory scale but increasingly also on an industrial scale. While conductive heating occasionally has been applied to peptide synthesis, precise microwave irradiation to heat the reaction ...
Pedersen, Søren Ljungberg +3 more
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Solid‐Phase synthesis of peptide nucleic acids
Journal of Peptide Science, 1995AbstractPeptide nucleic acids (PNA) were synthesized by a modified Merrifield method using several improvements. Activation by O‐(benzotriazol‐1‐yl)‐1,1,3,3‐tetramethyluronium hexafluorophosphate in combination with in situ neutralization of the resin allowed efficient coupling of all four Boc‐protected PNA monomers within 30 min.
Christensen, Leif +10 more
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Automated Synthesis of Solid Phase Bound Peptides
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Heinrich Gausepohl, Christian Behn
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