Results 271 to 280 of about 199,414 (326)
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Active esters in solid-phase peptide synthesis
Journal of Protein Chemistry, 1989Incorporation of single amino acid residues into peptide chains built on insoluble polymeric supports a priori appeared promising: the use of isolated, well defined (and potentially commercially available) reactive intermediates were expected to reduce the extent of undesired side reactions.
M, Bodanszky, M A, Bednarek
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1994
Abstract The chemical synthesis of oxytocin, with biological activity indistinguishable from that of the native hormone, by du Vigneaud and co-workers in 1953, represents a landmark in the application of synthetic peptides to the study of biology (1).
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Abstract The chemical synthesis of oxytocin, with biological activity indistinguishable from that of the native hormone, by du Vigneaud and co-workers in 1953, represents a landmark in the application of synthetic peptides to the study of biology (1).
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1988
By the conventional methods of organic synthesis, preparation of peptides containing more than just a few amino acids is an arduous task. Introduction of blocking groups, coupling reactions and deprotection steps entail a large number of operations, such as washing the reaction mixtures neutral after coupling, precipitation or crystallization of ...
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By the conventional methods of organic synthesis, preparation of peptides containing more than just a few amino acids is an arduous task. Introduction of blocking groups, coupling reactions and deprotection steps entail a large number of operations, such as washing the reaction mixtures neutral after coupling, precipitation or crystallization of ...
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1998
B. Merrifield, Concept and Early Development of Solid-Phase Peptide Synthesis. Methods for Solid-Phase Assembly of Peptides: P.F. Alewood, D. Alewood, L. Miranda, S. Love, W. Meutermans, and D. Wilson, Rapid in Situ Neutralization Protocols for Boc and Fmoc Solid-Phase Chemistries. J.M.
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B. Merrifield, Concept and Early Development of Solid-Phase Peptide Synthesis. Methods for Solid-Phase Assembly of Peptides: P.F. Alewood, D. Alewood, L. Miranda, S. Love, W. Meutermans, and D. Wilson, Rapid in Situ Neutralization Protocols for Boc and Fmoc Solid-Phase Chemistries. J.M.
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1991
This chapter discusses solid phase peptide synthesis, an idea which first appeared in a scientific publication by Merrifield in 1963. It explains why the term ‘solid phaseȉ is misleading, elaborating that the reactions do not take place in or on the surfaces of solid phases, but in gel systems produced by the penetration of solvent and solute molecules
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This chapter discusses solid phase peptide synthesis, an idea which first appeared in a scientific publication by Merrifield in 1963. It explains why the term ‘solid phaseȉ is misleading, elaborating that the reactions do not take place in or on the surfaces of solid phases, but in gel systems produced by the penetration of solvent and solute molecules
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Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids.
International journal of peptide & protein research, 2009G. Fields, R. Noble
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Solid phase peptide synthesis. I. the synthesis of a tetrapeptide
, 1963R. Merrifield
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Ultra-Efficient Solid-Phase Peptide Synthesis
Microwave peptide synthesis offers significant advantages for peptide production in speed, efficiency, and overall purity. This chapter surveys key developments including the introduction of a wash-free methodology that has enabled 95% waste reduction in peptide synthesis at both research and production level solid-phase peptide synthesis (SPPS ...Sandeep K, Singh, Jonathan M, Collins
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