Results 41 to 50 of about 199,414 (326)
Solid-Phase Total Synthesis of Plusbacin A3 [PDF]
, 2022 The total synthesis of the depsipeptide natural product plusbacin A3 (1) utilizing solid-phase peptide synthesis (SPPS) was disclosed. A 3-hydroxy-proline derivative compatible with Fmoc SPPS was prepared by a diastereoselective Joullié–Ugi three ...
Toyotaka Sato +17 more
core +1 more source
Synthesis of Chlorotoxin by Native Chemical Ligation
Journal of the Turkish Chemical Society, Section A: Chemistry, 2018 Chlorotoxin (CLTX) is a neurotoxin found in the venom of the Israeli scorpion, Leirius quinquestriatus. It contains 36-amino acids with four disulfide bonds and inhibits low-conductance chloride channels.
Ulvi Karaca +2 more
doaj +1 more source
Aqueous Microwave-Assisted Solid-Phase Synthesis Using Boc-Amino Acid Nanoparticles
Applied Sciences, 2013 We have previously developed water-based microwave (MW)-assisted peptide synthesis using Fmoc-amino acid nanopaticles. It is an organic solvent-free, environmentally friendly method for peptide synthesis.
Yoshinobu Fukumori +4 more
doaj +1 more source
Chemistry of Peptide-Oligonucleotide Conjugates: A Review
Molecules, 2021 Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability, and, thus, overall efficiency of therapeutic nucleic acids, such as ...
Kristina Klabenkova +2 more
doaj +1 more source
Exploration of the one-bead one-compound methodology for the design of prolyl oligopeptidase substrates. [PDF]
PLoS ONE, 2009 Here we describe the design, synthesis and evaluation of the first solid-phase substrates for prolyl oligopeptidase (POP), a cytosolic serine peptidase associated with schizophrenia, bipolar affective disorder and related neuropsychiatric disorders. This
Gemma Comellas +4 more
doaj +1 more source
Liquid-Phase Peptide Synthesis (LPPS): A Third Wave for the Preparation of Peptides.
Chemical Reviews, 2022 Since the last century, peptides have gained wide acceptance as drugs, with almost 100 already in the market and a large number in the pipeline. In this context, peptide synthesis has grown massively as a stringent field for pharmaceuticals around the ...
Anamika Sharma +3 more
semanticscholar +1 more source
Rapid microwave-assisted solid phase peptide synthesis [PDF]
, 2002 A microwave-assisted, rapid solid phase peptide synthesis procedure is presented. It has been applied to the coupling of sterically hindered Fmoc-protected amino acids yielding di- and tripeptides.
Gogoll, Adolf,, Erdelyi, Mate,
core +1 more source
Solid Phase Peptide Synthesis [PDF]
, 2022 The research done last semester was on solid-phase peptide synthesis. The technique of solid-phase peptide synthesis consists of molecules that are bound to a solid frame and using protected amino acids, the peptide is synthesized step-by-step, obtaining
Martinez, Millie
core
Solid-Phase Synthesis of the Lipopeptide Myr-HBVpreS/2-78, a Hepatitis B Virus Entry Inhibitor
Molecules, 2010 Chronic HBV infection is the leading cause of liver cirrhosis and hepatocellular carcinoma (HCC). Synthetic peptides derived from the N-terminus of the large HBV envelope protein (L-protein) have been shown to efficiently block HBV entry.
Walter Mier +5 more
doaj +1 more source
DNA display III. Solid-phase organic synthesis on unprotected DNA. [PDF]
PLoS Biology, 2004 DNA-directed synthesis represents a powerful new tool for molecular discovery. Its ultimate utility, however, hinges upon the diversity of chemical reactions that can be executed in the presence of unprotected DNA.
David R Halpin +3 more
doaj +1 more source