Results 21 to 30 of about 129,944 (294)
Solid-Phase Synthesis of Oxetane Modified Peptides [PDF]
Organic Letters, 2017 Solid-phase peptide synthesis (SPPS) is used to create peptidomimetics in which one of the backbone amide C═O bonds is replaced by a four-membered oxetane ring. The oxetane containing dipeptide building blocks are made in three steps in solution, then integrated into peptide chains by conventional Fmoc SPPS.
Jonathan D. Beadle +5 more
openaire +3 more sources
Solid Phase versus Solution Phase Synthesis of Heterocyclic Macrocycles
Molecules, 2013 Comparing a solution phase route to a solid phase route in the synthesis of the cytotoxic natural product urukthapelstatin A (Ustat A) confirmed that a solid phase method is superior.
Shelli R. McAlpine, Seong Jong Kim
doaj +1 more source
Epimerisation in Peptide Synthesis
Molecules, 2023 Epimerisation is basically a chemical conversion that includes the transformation of an epimer into another epimer or its chiral partner. Epimerisation of amino acid is a side reaction that sometimes happens during peptide synthesis.
Suleman Duengo +4 more
doaj +1 more source
Realizing Serine/Threonine Ligation: Scope and Limitations and Mechanistic Implication Thereof
Frontiers in Chemistry, 2014 Serine/Threonine ligation (STL) has emerged as an alternative tool for protein chemical synthesis, bioconjugations as well as macrocyclization of peptides of various sizes. Owning to the high abundance of Ser/Thr residues in natural peptides and proteins,
Clarence T. T. Wong +10 more
doaj +1 more source
Synthesis of cyclotetrapeptide analogues of c-PLAI and evaluation of their antimicrobial properties [PDF]
Royal Society Open Science, 2021 Antimicrobial peptides (AMPs) are interesting compounds owing to their ability to kill several pathogens. In order to identify new AMPs, c-PLAI analogues were synthesized and evaluated together with their linear precursors for their antimicrobial ...
Rani Maharani +8 more
doaj +1 more source
Synthesis of Chlorotoxin by Native Chemical Ligation
Journal of the Turkish Chemical Society, Section A: Chemistry, 2018 Chlorotoxin (CLTX) is a neurotoxin found in the venom of the Israeli scorpion, Leirius quinquestriatus. It contains 36-amino acids with four disulfide bonds and inhibits low-conductance chloride channels.
Ulvi Karaca +2 more
doaj +1 more source
Solid-Phase Unnatural Peptide Synthesis (UPS)
, 2016 Solid-Phase Unnatural Peptide Synthesis ...
Martin J. O'Donnell (2489491) +2 more
core +2 more sources
Aqueous Microwave-Assisted Solid-Phase Synthesis Using Boc-Amino Acid Nanoparticles
Applied Sciences, 2013 We have previously developed water-based microwave (MW)-assisted peptide synthesis using Fmoc-amino acid nanopaticles. It is an organic solvent-free, environmentally friendly method for peptide synthesis.
Yoshinobu Fukumori +4 more
doaj +1 more source
Chemistry of Peptide-Oligonucleotide Conjugates: A Review
Molecules, 2021 Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability, and, thus, overall efficiency of therapeutic nucleic acids, such as ...
Kristina Klabenkova +2 more
doaj +1 more source
Exploration of the one-bead one-compound methodology for the design of prolyl oligopeptidase substrates. [PDF]
PLoS ONE, 2009 Here we describe the design, synthesis and evaluation of the first solid-phase substrates for prolyl oligopeptidase (POP), a cytosolic serine peptidase associated with schizophrenia, bipolar affective disorder and related neuropsychiatric disorders. This
Gemma Comellas +4 more
doaj +1 more source