Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis [PDF]
Beilstein Journal of Organic Chemistry, 2018 The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis.
Dan Liu, Ya-Li Guo, Jin Qu, Chi Zhang
doaj +3 more sources
Safety-Catch Linkers for Solid-Phase Peptide Synthesis [PDF]
MoleculesSolid-phase peptide synthesis (SPPS) is the preferred strategy for synthesizing most peptides for research purposes and on a multi-kilogram scale. One key to the success of SPPS is the continual evolution and improvement of the original method proposed ...
Sikabwe Noki +2 more
doaj +2 more sources
A Photolabile Carboxyl Protecting Group for Solid Phase Peptide Synthesis [PDF]
ChemistryOpen, 2021 A new kind of photolabile protecting group (PLPG) for carboxyl moieties was designed and synthesized as the linker between resin and peptide. This group can be used for the protection of amino acid carboxyl groups.
Hongpeng Yang +8 more
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Deprotection Reagents in Fmoc Solid Phase Peptide Synthesis: Moving Away from Piperidine? [PDF]
Molecules, 2016 The deprotection step is crucial in order to secure a good quality product in Fmoc solid phase peptide synthesis. 9-Fluorenylmethoxycarbonyl (Fmoc) removal is achieved by a two-step mechanism reaction favored by the use of cyclic secondary amines ...
Omar Luna +5 more
semanticscholar +2 more sources
A practical synthesis of the 13C/15N-labelled tripeptide N-formyl-Met-Leu-Phe, useful as a reference in solid-state NMR spectroscopy [PDF]
Beilstein Journal of Organic Chemistry, 2008 A mild synthetic method for N-formyl-Met-Leu-Phe-OH (1) is described. After Fmoc solid phase peptide synthesis, on-bead formylation and HPLC purification, more than 30 mg of the fully 13C/15N-labelled tripeptide 1 could be isolated in a typical batch ...
Sven T. Breitung +5 more
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Solid‐phase peptide synthesis in 384‐well plates [PDF]
Journal of Peptide ScienceNewer solid‐phase peptide synthesis and release strategies enable the production of short peptides with high purity, allowing direct screening for desired bioactivity without prior chromatographic purification.
M. Schüttel +6 more
semanticscholar +2 more sources
Triethyl phosphate (TEP) as a green solvent for solid-phase peptide synthesis (SPPS)
Green Chemistry Letters and ReviewsTriethyl phosphate (TEP) is a new member of the Green Solid-Phase Peptide Synthesis (GSPPS) toolbox. TEP shows almost no toxicity and no carcinogenic or mutagenic properties. It degrades, giving the rather innocuous phosphoric acid and ethanol. TEP has a
K.P. Nandhini +3 more
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Automated solid-phase peptide synthesis to obtain therapeutic peptides
Beilstein Journal of Organic Chemistry, 2014 The great versatility and the inherent high affinities of peptides for their respective targets have led to tremendous progress for therapeutic applications in the last years.
Veronika Mäde +2 more
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Synthetic Evaluation of Standard and Microwave-Assisted Solid Phase Peptide Synthesis of a Long Chimeric Peptide Derived from Four Plasmodium falciparum Proteins [PDF]
Molecules, 2018 An 82-residue-long chimeric peptide was synthesised by solid phase peptide synthesis (SPPS), following the Fmoc protocol. Microwave (MW) radiation-assisted synthesis was compared to standard synthesis using low loading (0.20 mmol/g) of polyethylene ...
Yahson F. Varela +2 more
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Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis. [PDF]
ACS Omega, 2023 Herein, we report dipropylamine (DPA) as a fluorenylmethyloxycarbonyl (Fmoc) deprotection reagent to strongly reduce aspartimide formation compared to piperidine (PPR) in high-temperature (60 °C) solid-phase peptide synthesis (SPPS).
Personne H +3 more
europepmc +3 more sources