Results 71 to 80 of about 129,944 (294)

Synthetic receptors for the differentiation of phosphorylated peptides and synthesis and use of tetrahydrofuran amino acids

, 2010
In the first part of the work a combination of bis(Zn(II)-cyclen) triazine metal complex binding sites with guanidinium moieties or Zn(II)-NTA complexes leads to artificial receptors for the differentiation of phosphorylated peptides which contain either
Grauer, Andreas
core   +1 more source

Bacterial‐Electrochemical Platform Utilizing a MXene‐Peptide Hydrogel

Advanced Functional Materials, EarlyView.
A peptide‐based fibrillar hydrogel incorporating MXene facilitates efficient electron delivery to intracellular recombinant [FeFe]‐hydrogenase enzyme in E. coli, enabling sustained bioelectrochemical H2 production without engineered exoelectrogenicity pathways.
Oren Ben‐Zvi, Itzhak Grinberg, Or Messer, Dana Cohen‐Gerassi, Maxim Sokol, Iftach Yacoby, Lihi Adler‐Abramovich   +6 more
wiley   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

SYNTHESIS OF OLIGOPEPTIDES OF DEFINED FRAGMENT COMPOSITION [PDF]

Journal of IMAB, 2011
The advantages of the solid-phase peptide synthesis were used. The peptide chain was built on specially processed insoluble polymer resin: Wang- and Rink Amide MBHA-resin.
Tamara Paypanova, Tatyana Hristova, Rumyana Cherkezova   +2 more
doaj  

Peptide Synthesis

Bio-Protocol, 2012
This protocol describes the synthesis of peptides for affinity testing and bioconjugate with solid phase peptide synthesizer at a small scale.
zheng miao, Zhen Cheng
doaj   +1 more source

Double‐Interpenetrating Composite Bioink for Multi‐Component 3D Bioprinting and Biofabrication

Advanced Functional Materials, EarlyView.
Marine‐polysaccharides‐derived double interpenetrating network hydrogel‐based bioink, combining the attributes of physical and ionic crosslinking, enables room‐temperature bioprinting of mechanically defined structures that can be handled and are cytocompatible.
Fabian Tribukait‐Riemenschneider, V. Prasad Shastri   +1 more
wiley   +1 more source

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

Automated solid-phase peptide synthesis to obtain therapeutic peptides

Beilstein Journal of Organic Chemistry, 2014
The great versatility and the inherent high affinities of peptides for their respective targets have led to tremendous progress for therapeutic applications in the last years.
Veronika Mäde, Sylvia Els-Heindl, Annette G. Beck-Sickinger   +2 more
doaj   +1 more source

Solid Phase Peptide Synthesis: Analysis and Identification of Protein Kinase Substrates

, 2005
This research study examines the synthesis of tyrosine containing peptides based on the protein paxillin. Paxillin is a proposed substrate of the Focal Adhesion Kinase (FAK) protein tyrosine kinase.
Kroodsma, Derrick
core  

Packed Hydrogel Microfibers as Scaffolds Supporting Dynamic Cellular Behavior and Biomaterial Inks in 3D Printing

Advanced Healthcare Materials, EarlyView.
Packed hydrogel microfiber (PHM) materials consist of flexible and high aspect ratio hydrogel components that, as a bulk material, are simultaneously mechanically robust and dynamic. Cells cultured in or on PHM scaffolds can be influenced by topographical cues or interact with a dynamic environment that permits cell spreading and multicellular ...
M. Gregory Grewal, Remington M. Martinez, Georgia T. Helein, Montserrath G. Ibarra Rivera, Rodolfo Martinez Jr., Jenna L. Sumey, Steven R. Caliari, Christopher B. Highley   +7 more
wiley   +1 more source