Results 81 to 90 of about 199,414 (326)

Preparation and Application of an Inexpensive α-Formylglycine Building Block Compatible with Fmoc Solid-Phase Peptide Synthesis [PDF]

, 2022
α-Formylglycine (fGly) is a rare residue located in the active site of sulfatases, and serves as a precursor to pharmaceu-tically-relevant motifs. The installation of fGly motifs into peptides is currently challenging due to degradation under the acidic ...
Martin, Fascione, Nicholas, Yates, Nathalie, Signoret, Reuben, Breetveld, Matthew, Warnes, Christopher, Spicer   +5 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Chemical synthesis of proteins: a tool for protein labeling [PDF]

, 2010
An ingenious stratagem useful to understand and modulate the structural and functional features of the proteins refers to the modification of their chemical structure.
De Rosa, Lucia
core  

Pushing the Limits of Solid-Phase Peptide Synthesis with Continuous Flow [PDF]

Since its invention by Bruce Merrifield, solid-phase peptide synthesis has conventionally been performed in batch reactors. With systems created by Atherton, Dryland, and Sheppard in the 1980s, flow-chemistry techniques began to be applied to enhance ...
Steinauer, Angela, Mijalis, A. J., Schepartz, A., Pentelute, B. L.   +3 more
core   +1 more source

Insights into the preparation of selenopeptides awaiting functional validation for fatigue mitigation: a comprehensive review

Food Science of Animal Products
Fatigue, a debilitating condition arising from intense physical and mental stress, significantly impairs work capacity and well-being, yet effective molecular interventions remain scarce.
Yuxiao Guo, Wei Jia, Rong Zhang, Bo He, Fen Ao, Haizhen Mo   +5 more
doaj   +1 more source

Synthetic Peptide Purification via Solid-Phase Extraction with Gradient Elution: A Simple, Economical, Fast, and Efficient Methodology

Molecules, 2019
A methodology was implemented for purifying peptides in one chromatographic run via solid-phase extraction (SPE), reverse phase mode (RP), and gradient elution, obtaining high-purity products with good yields.
Diego Sebastián Insuasty Cepeda, Héctor Manuel Pineda Castañeda, Andrea Verónica Rodríguez Mayor, Javier Eduardo García Castañeda, Mauricio Maldonado Villamil, Ricardo Fierro Medina, Zuly Jenny Rivera Monroy   +6 more
doaj   +1 more source

Molecular Adsorbing Host•Guest (MAHG) Crystals: A New Paradigm for Porous Materials?

Advanced Functional Materials, EarlyView.
Networking! Introduction of guest molecules in macrocycles before crystallization profoundly influences the material obtained in terms of structure and function. Beside simplicity and porous space improvement, this approach is endowed with a huge potential given the myriad of potential guest molecules that can be used to tune this burgeoning class of ...
Ingrid Suzana, Michel Giorgi, Anthony Kermagoret, Alexandre Martinez, David Bardelang   +4 more
wiley   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Solid-Phase Synthesis of C‑Terminus Cysteine Peptide Acids [PDF]

, 2022
Cysteine (Cys) is a key amino acid in many therapeutic peptides. For research and industrial purposes, solid-phase peptide synthesis is the method of choice for the preparation of most peptides.
Amit Chakraborty, Ralph Schönleber (14124123), Mthembu, Sinenhlanhla N., Schönleber, Ralph, Ralph Schönleber, Beatriz G. de la Torre (7399865), De La Torre, Beatriz G., Beatriz G. de la Torre, Amit Chakraborty (1576222), Chakraborty, Amit, Albericio, Fernando, Sinenhlanhla N. Mthembu (8052380), Sinenhlanhla N. Mthembu, Fernando Albericio (442020), Fernando Albericio   +14 more
core   +1 more source

Water‐Compatible SuFEx‐Active Diazonium Linchpin Platform for Rapid Modular Diversification and On‐DNA Functionalization

Advanced Functional Materials, EarlyView.
Sulfur fluoride exchange (SuFEx) is a powerful click platform, yet water‐compatible multifunctional linchpins remain elusive. Here, we report decagram‐scalable diazonium linchpins that enable rapid Pd‐catalyzed diversification and direct, catalyst‐free on‐DNA ligation in aqueous media.
Seok Ju Hong, Dong Hyeon Kim, Yujin Lim, Yongseok Kwon, Sangkyu Lee, Han Yong Bae   +5 more
wiley   +1 more source