Results 81 to 90 of about 1,533,510 (152)

PEMBUATAN S-SNEDDS (SOLID SELF NANO-EMULSIFYING DRUG DELIVERY SYSTEM) KETOPROFEN DENGAN ASAM OLEAT SEBAGAI FASE MINYAK, TWEEN 20 SEBAGAI SURFAKTAN DAN PROPILEN GLIKOL SEBAGAI KO-SURFAKTAN SERTA AEROSIL SEBAGAI SOLIDIFYING AGENT

, 2014
Ketoprofen, commonly used in rheumatoid arthritis treatment, has low solubility and cause gastritis while using orally. Solid SNEDDS can overcome this problem by forming an o/w nanoemulsion in gastric fluid.
, Dr. rer. nat. Ronny Martien, M.Si., , ELVA RUSMAYANTI SURYA   +1 more
core  

A Comprehensive Review of Solid Self Nano Emulsifying Drug Delivery System (S-SNEDDS) Technology to Enhance Nanoemulsion Stability [PDF]

Patients and practitioners prefer oral medication administration for systemic or local treatment due to its convenience and pleasurable experience. Nevertheless, numerous oral pharmaceutical formulations encounter various delivery challenges as a result ...
Yandi Syukri, Syafira Tri Nurmala Sari, Arba Pramundita Ramadani   +2 more
core   +1 more source

Design, Optimization, and Solidification of Atazanavir-Loaded Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Enhanced Oral Bioavailability [PDF]

The present study aimed to enhance the oral bioavailability of atazanavir sulfate, a BCS Class II antiretroviral drug characterized by poor aqueous solubility, through development of a solid self-nanoemulsifying drug delivery system (S-SNEDDS).
Khatri, Kavitha AN
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Digital images of CN liquid SNEDDS at different storage conditions.

, 2018
(A) Freshly prepared liquid SNEDDS; (B) Liquid SNEDDS after a minimum of 6 months of accelerated storage conditions; (C) Liquid SNEDDS after a minimum of 6 months of intermediate storage conditions; (D) Liquid SNEDDS after a minimum of 12 months of long ...
Fars Kaed Alanazi (5537078), Ahmad Abdul-Wahhab Shahba (5537081), Sayed Ibrahim Abdel-Rahman (5537084)   +2 more
core   +1 more source

Solid self-nanoemulsifying drug delivery systems of nimodipine: development and evaluation

Future Journal of Pharmaceutical Sciences
Background This study aimed to formulate solid self-nanoemulsifying drug delivery systems (SNEDDS) for nimodipine (NIM). The selection of Cremophor RH 40, Lipoxol 300, and PEG 400 as oil, surfactant, and co-surfactant was based on solubility and self ...
Mohit Kumar, Pooja A. Chawla, Abdul Faruk, Viney Chawla   +3 more
doaj   +1 more source

Supersaturated Self-Nanoemulsifying Drug Delivery Systems (super-SNEDDS)

, 2012
Purpose: The broader application of self-nanoemulsifying drug delivery systems (SNEDDS) has been hampered by the limited solubility of lipophilic, hydrophobic drugs, often requiring the inconvenient dosing of multiple units.
Thomas, Nicky Dieter
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PENGARUH PENGERING AEROSIL DAN KROSPOVIDON TERHADAP KARAKTERISTIK FISIK SOLID-SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM KURKUMIN

JIIS: Jurnal Ilmiah Ibnu Sina
Kurkumin termasuk dalam BCS II dengan kelarutan rendah namun permeabilitas tinggi. Pada penelitian sebelumnya telah diperoleh SNEDDS kurkumin dengan komposisi kurkumin 7 mg/mL, VCO (11%), tween 80 (65,66%) dan PEG 400 (23,34%), namun sediaan tersebut ...
Iis Wahyuningsih, Muhammad Rhapis Kyllingga   +1 more
doaj   +1 more source

Formulation Development of Solid Self-Nanoemulsifying Drug Delivery Systems of Quetiapine Fumarate via Hot-Melt Extrusion Technology: Optimization Using Central Composite Design

Pharmaceutics
Quetiapine fumarate (QTF) was approved for the treatment of schizophrenia and acute manic episodes. QTF can also be used as an adjunctive treatment for major depressive disorders. QTF oral bioavailability is limited due to its poor aqueous solubility and
Prateek Uttreja, Ahmed Adel Ali Youssef, Indrajeet Karnik, Kavish Sanil, Nagarjuna Narala, Honghe Wang, Rasha M. Elkanayati, Sateesh Kumar Vemula, Michael A. Repka   +8 more
doaj   +1 more source

Quality by design aided self-nano emulsifying drug delivery systems development for the oral delivery of Benidipine: Improvement of biopharmaceutical performance

Drug Delivery
The primary objective of the research effort is to establish efficient solid self-nanoemulsifying drug delivery systems (S-SNEDDS) for benidipine (BD) through the systematic application of a quality-by-design (QbD)-based paradigm.
Sheetal S. Buddhadev, Kevinkumar C. Garala, Saisivam S, Mohamed Rahamathulla, Mohammed Muqtader Ahmed, Syeda Ayesha Farhana, Ismail Pasha   +6 more
doaj   +1 more source

A Critical Review of SNEDDS: Mechanistic Basis, Formulation Advances, and Future Directions in Oral Drug Delivery

: Although many newly developed therapeutic compounds exhibit low bioavailability due to poor aqueous solubility and limited gastrointestinal permeability, oral drug delivery remains the preferred route of administration because of ...
Sonali Dasharath Mali, Prachi Suresh Patil, Rabbika Rajjak Attar, Gauri Sachin Admuthe, Prajakta Kirankumar Kavathekar, Pravin Kondiba Pawar   +5 more
core   +1 more source