Results 11 to 20 of about 2,906,554 (204)
Computing the aqueous solubility of organic drug-like molecules and understanding hydrophobicity [PDF]
, 2015 This thesis covers a range of methodologies to provide an account of the current (2010-2014) state of the art and to develop new methods for solubility prediction.
McDonagh, James L.
core +2 more sources
Pharmaceutics, 2023 Different deep eutectic systems (DES) of choline chloride (CC)–urea (UA) (1:2), CC–glycerol (GLY) (1:2), CC–malonic acid (MA) (1:1), and CC–ascorbic acid (AA) (2:1) were generated and characterized by polarized light microscope (PLM) and Fourier ...
Soumalya Chakraborty +5 more
doaj +1 more source
SOLUBILITY AND DISSOLUTION ENHANCEMENT OF KETOTIFEN BY SOLID DISPERSION TECHNIQUE [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2015 Ketotifen (KT) solid dispersions and physical mixtures were prepared with the objective of solubility and dissolution improvement using Hydroxypropyl-Beta-Cyclodextrin (HP-β-CD), Pluronic 127 (PF-127), Pluronic 68 (PF-68), Polyethylene glycol 6000 (PEG ...
Omnia Mahmoud +2 more
doaj +1 more source
Pharmaceuticals, 2023 In this present research, an attempt has been made to address the influence of drug-coformer stoichiometric ratio on cocrystal design and its impact on improvement of solubility and dissolution, as well as bioavailability of poorly soluble telmisartan ...
Manami Dhibar +7 more
doaj +1 more source
Influence of pH, Temperature and Impurities on the Solubility of an Active Pharmaceutical Ingredient (API) [PDF]
, 2010 Solubility, which defines the liquid /solid equilibrium, is a key parameter to control a crystallization process. This work is focused on the effects of pH, temperature and impurities on the aqueous solubility of an Active Pharmaceutical Ingredient (API).
Estime, Nicolas +3 more
core +1 more source
Frontiers in Pharmacology, 2018 Background: The choice of lipid excipients and their origin are crucial determinant factors in the design of self-nanoemulsifying drug delivery system (SNEDDS).Aim: To investigate the aspects of alternative excipients which can influence the development ...
Aws Alshamsan +4 more
doaj +1 more source
Development of novel paracetamol/naproxen co-crystals with an improvement in naproxen solubility.
Iraqi Journal of Pharmaceutical Sciences, 2022 Co-crystals are new solid forms of drugs that could resolve more than one problem associated with drugs formulations like solubility, stability, bioavailability, mechanical and tableting properties.
Amal Fakhrulddin Al-Dulaimi +2 more
doaj +1 more source
Solubility and bioavailability improvement of pazopanib hydrochloride [PDF]
International Journal of Pharmaceutics, 2018 The anti-cancer drug pazopanib hydrochloride (PZH) has a very low aqueous solubility and a variable oral bioavailability. A new pharmaceutical formulation with an improved solubility may enhance the bioavailability and reduce the variability. A broad selection of polymer excipients was tested for their compatibility and solubilizing properties by ...
Herbrink, Maikel +6 more
openaire +4 more sources
Dehydroepiandrosterone Cocrystals with Improved Solubility and Bioavailability
Pharmaceutics, 2022 Dehydroepiandrosterone (DHEA) is an FDA-approved food supplement used as an assisted reproductive sex hormone. The bioavailability is severely limited by its poor solubility (23 µg/mL). Herein, we aimed to modulate its solubility through cocrystallization.
Yihua Jiang +7 more
openaire +3 more sources
Water solubility in aluminosilicate melts of haplogranite composition at 2 kbar [PDF]
, 1992 The compositional dependence of H2O solubility was investigated at 2 kbar and 800°C in haplogranite melts (system SiO2---1bNaAlSi3O8---1bKAlSi3O8 or Qz---1bAb---1bOr).
Taylor, Richard P. +3 more
core +1 more source