Results 101 to 110 of about 5,620 (124)

Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses

Immunologic Research, 2020
Aberrant T helper-2 (Th2) responses play a critical role in the pathogenesis of allergic diseases. The underlying mechanism is to be further investigated. It is reported that soluble CD83 (sCD83) has immune-regulatory effects. This study aims to investigate the role of sCD83 in the regulation of Th2 polarization.
Wenyue Song, Hongfen Li, Bingkun Jia, Zhenxi Wang, Qingsheng Liu, Guangping Yang, Xiaorong Li   +6 more
openaire   +2 more sources

Soluble CD83 inhibits human monocyte differentiation into dendritic cells in vitro

Cellular Immunology, 2014
Human CD83 is type I transmembrane glycoprotein, mainly expressed on mature dendritic cells (DCs), so it was first described as a molecular marker for mature DC. However, increasing evidence has demonstrated that CD83 is also an immunomodulatory molecule either its membrane-bound CD83 (mCD83) or soluble CD83 (sCD83) released from DCs. Intriguingly, the
Hongyu, Lin, Shuang, Liang, Zhenyu, Zhong, Jiexia, Wen, Wenyan, Li, Liyue, Wang, Jian, Xu, Fei, Zhong, Xiujin, Li   +8 more
openaire   +2 more sources

Release and clinical significance of soluble CD83 in chronic lymphocytic leukemia

Leukemia Research, 2009
Soluble CD83 (sCD83), a potent immunosuppressive agent, circulates at elevated levels in some chronic lymphocytic leukemia (CLL) patients. We report that CLL patients with elevated plasma sCD83 levels had significantly shorter (P=0.038) treatment free survival.
B D, Hock, L J, Fernyhough, S M, Gough, A, Steinkasserer, A G, Cox, J L, McKenzie   +5 more
openaire   +2 more sources

The levels of soluble forms of CD21 and CD83 in multiple sclerosis

Journal of Neuroimmunology, 2018
Multiple Sclerosis (MS) is a neuroinflammatory disease of the central nervous system (CNS) in which immune system plays a crucial role in progression of the disease. An enormous amount of research has been shown that immune mediators such as cytokines and chemokines are the culprits of MS propagation suggesting that modulation of such molecules may ...
Sajad, Karampoor, Hamid, Zahednasab, Masoud, Etemadifar, Hossein, Keyvani   +3 more
openaire   +2 more sources

Immunosuppression Involving Soluble CD83 Induces Tolerogenic Dendritic Cells That Prevent Cardiac Allograft Rejection

Transplantation, 2010
Dendritic cells (DCs) are crucial regulators of immunity and important in inducing and maintaining tolerance. Here, we investigated the potential of a novel DC-immunomodulating agent, soluble CD83 (sCD83), in inducing transplant tolerance.We used the C3H-to-C57BL/6 mouse cardiac transplantation model that exhibits a combination of severe cell-mediated ...
Wei, Ge, Jacqueline, Arp, Dameng, Lian, Weihua, Liu, Miren L, Baroja, Jifu, Jiang, Siobhan, Ramcharran, Firas Zahr, Eldeen, Elisabeth, Zinser, Alexander, Steinkasserer, Perry, Chou, Stephen, Brand, Charles, Nicolette, Bertha, Garcia, Hao, Wang   +14 more
openaire   +2 more sources

Porcine CD83 is a glycosylated dimeric protein existing naturally in membrane-bound and soluble forms

Developmental & Comparative Immunology, 2019
Human and mouse CD83 have been well characteized, however, the other mammalian CD83 genes have not been cloned and characterized. In this study, the porcine CD83 (pCD83) was cloned, expressed and characterized, and showed that the pCD83 gene has 81% and 74% homologies with humans and mice, respectively, which was identified to be glycosylated when ...
Shanshan, Huo, Jianlou, Zhang, Fengyang, Wu, Yuzhu, Zuo, Dan, Cui, Xiujin, Li, Zhenyu, Zhong, Fei, Zhong   +7 more
openaire   +2 more sources

The soluble form of CD83 is present at elevated levels in a number of hematological malignancies

Leukemia Research, 2004
Recombinant forms of soluble CD83 (sCD83) inhibit anti-tumor responses. In this analysis of circulating sCD83 levels we report that although >95% of acute myeloid leukemia (AML) and multiple myeloma (MM) patients have normal or only weakly elevated sCD83 levels, 20% of chronic lymphocytic leukemia (CLL) and 5/7 mantle cell lymphoma (MCL) patients have ...
Barry D, Hock, Lisa F, Haring, Alexander, Steinkasserer, Karen G, Taylor, William N, Patton, Judith L, McKenzie   +5 more
openaire   +2 more sources

Porcine soluble CD83 alleviates LPS-induced abortion in mice by promoting Th2 cytokine production, Treg cell generation and trophoblast invasion

Theriogenology, 2020
CD83, either in its membrance-bound form (mCD83) or soluble form (sCD83), is an important immunomodulatory molecule in humans and mice. While mCD83 is immunostimulatory, sCD83 exhibits striking immunosuppressive activities, suggesting that sCD83 may be used to combat inflammatory diseases, such as rheumatoid arthritis, graft-versus-host disease and ...
Shanshan, Huo, Fengyang, Wu, Jianlou, Zhang, Xing, Wang, Wenyan, Li, Dan, Cui, Yuzhu, Zuo, Man, Hu, Fei, Zhong   +8 more
openaire   +2 more sources

Membrane-bound and soluble porcine CD83 functions antithetically in T cell activation and dendritic cell differentiation in vitro

Developmental & Comparative Immunology, 2019
Emerging evidence suggests that CD83, a dendritic cells (DCs) maturation marker in humans and mice, may prossess immunomodulatory capacities. Although porcine CD83 shares ∼75% sequence homology with its human counterpart, whether it functions as an immunoregulatory molecule remains unknown. To investigate porcine CD83 function, we deleted it in porcine
Shanshan, Huo, Jianlou, Zhang, Shuang, Liang, Fengyang, Wu, Yuzhu, Zuo, Dan, Cui, Yonghong, Zhang, Zhenyu, Zhong, Fei, Zhong   +8 more
openaire   +2 more sources

Production and characterization of human soluble CD83 fused with the fragment crystallizable region of human IgG1 in Pichia pastoris

Applied Microbiology and Biotechnology, 2013
The cell surface protein CD83 belongs to the immunoglobulin superfamily and is highly expressed on mature dendritic cells. The soluble form of CD83, sCD83, is a potential immune suppressor. In a previous study, recombinant soluble CD83 was expressed in Escherichia coli, resulting in a lack of functional glycosylation.
Yuan, Y., Wan, L., Chen, Younan, Shi, M., Wang, C., Zhao, J., Lu, X., Wang, H., Lu, Y., Cheng, J.   +9 more
openaire   +3 more sources