Results 111 to 120 of about 5,620 (124)

Induction of Kidney Allograft Tolerance by Soluble CD83 Associated With Prevalence of Tolerogenic Dendritic Cells and Indoleamine 2,3-Dioxygenase

Transplantation, 2010
Tolerogenic dendritic cells (Tol-DCs) play a critical role in inducing and maintaining tolerance. Recognizing that both T-cell inactivation and activation are contingent on signals provided by DCs and that graft-specific activated T cells are major mediators of transplant rejection, we aimed to create an environment favoring Tol-DCs with a novel ...
Zhu, Lan, Wei, Ge, Jacqueline, Arp, Jifu, Jiang, Weihua, Liu, Dina, Gordon, Don, Healey, Mark, DeBenedette, Charles, Nicolette, Bertha, Garcia, Hao, Wang   +10 more
openaire   +2 more sources

Expression of soluble CD83 in plasma from early-stage rheumatoid arthritis patients is not modified by anti-TNF-α therapy

Cytokine, 2017
Rheumatoid arthritis (RA) is an autoimmune disease which may lead to severe disabilities due to structural joint damage and extraarticular manifestations The dendritic cell marker CD83 belongs to the immunoglobulin superfamily and has previously been associated with autoimmune diseases.
Anne-Mette Kristensen, Kristian Stengaard-Pedersen, Merete Lund Hetland, Kim Hørslev-Petersen, Peter Junker, Mikkel Østergaard, Per Höllsberg, Bent Deleuran, Malene Hvid   +8 more
openaire   +5 more sources

Levels of the soluble forms of CD80, CD86, and CD83 are elevated in the synovial fluid of rheumatoid arthritis patients

Tissue Antigens, 2005
AbstractThe release of soluble forms of CD80 (sCD80), CD86 (sCD86), and CD83 (sCD83) provide a potentially powerful immunoregulatory mechanism. We therefore investigated the potential presence and relative levels of these molecules in the synovial fluid (SF) and serum of patients with rheumatoid arthritis (RA) and osteoarthritis (OA).
B D, Hock, J L, O'Donnell, K, Taylor, A, Steinkasserer, J L, McKenzie, A G, Rothwell, K L, Summers   +6 more
openaire   +2 more sources

Increased levels of circulating soluble CD14 but not CD83 in infants are associated with early intestinal colonization with Staphylococcus aureus

Clinical & Experimental Allergy, 2006
SummaryBackground Soluble forms of the monocyte marker CD14 and the mature dendritic cell marker CD83 are plasma proteins with immunoregulatory functions. The physiological stimulus for their production is unclear and their possible role in allergy development is unknown.Methods We measured the plasma levels of soluble CD14 (sCD14) and ...
A-C, Lundell, I, Adlerberth, E, Lindberg, H, Karlsson, S, Ekberg, N, Aberg, R, Saalman, B, Hock, A, Steinkasserer, B, Hesselmar, A E, Wold, A, Rudin   +11 more
openaire   +2 more sources

Infection of mature monocyte-derived dendritic cells with human cytomegalovirus inhibits stimulation of T-cell proliferation via the release of soluble CD83

Blood, 2004
AbstractWe have studied the mechanisms by which human cytomegalovirus (HCMV) infection of monocyte-derived dendritic cells (moDCs) contribute to immune suppression. Unlike infection of immature moDCs, infection of mature moDCs is not lytic and results in minimally decreased surface major histocompatibility complex (MHC) and costimulatory molecule ...
Brigitte, Sénéchal, Adam M, Boruchov, John L, Reagan, Derek N J, Hart, James W, Young   +4 more
openaire   +2 more sources

Failed efficacy of soluble human CD83-Ig in allogeneic mixed lymphocyte reactions and experimental autoimmune encephalomyelitis: Implications for a lack of therapeutic potential

Immunology Letters, 2008
Soluble forms of CD83, a dendritic cell-specific surface glycoprotein, have been strongly proposed to be of therapeutic utility in inflammatory conditions such as multiple sclerosis and transplantation. We demonstrate here, however, that eukaryotically expressed, recombinant soluble human CD83-Ig molecules fail to achieve efficacy in model systems for ...
Achal, Pashine, Ulrich, Göpfert, Jinzhi, Chen, Eike, Hoffmann, Paul S, Dietrich, Stanford L, Peng   +5 more
openaire   +2 more sources

WITHDRAWN: Failed efficacy of soluble human CD83-Ig in allogeneic mixed lymphocyte reactions and experimental autoimmune encephalomyelitis: implications for a lack of therapeutic potential?

Immunology Letters, 2007
This article has been withdrawn consistent with Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). The Publisher apologizes for any inconvenience this may cause.
Achal, Pashine, Ulrich, Göpfert, Jinzhi, Chen, Eike, Hoffmann, Paul S, Dietrich, Stanford L, Peng   +5 more
openaire   +2 more sources

Production of Recombinant Human Soluble CD83 in an Eukaryotic System and Generation of Tissue-Specific CD83 Knock-out Mice

2011
Das glykosylierte Transmembranprotein CD83 mit einer Molekülmasse von 45kDa gehört zur Immunoglobulin-Superfamilie. CD83 wird von Langerhans- und Retikulumzellen, sowie von aktivierten Lymphozyten exprimiert. Darüber hinaus ist CD83 vor allem als eines der besten Oberflächenmarkerproteine auf humanen, reifen dendritischen Zellen (DZ) bekannt.
openaire   +1 more source

SUPPRESSION OF ANTIDONOR ANTIBODY RESPONSE BY SOLUBLE CD83 PREVENTS CHRONIC RENAL ALLOGRAFT REJECTION

Transplantation Journal, 2010
Z. Lan, W. Ge, J. Arp, W. Liu, S. Brand, D. Healey, C. Nicolette, B. Garcia, H. Wang   +8 more
openaire   +1 more source

Published studies reporting the efficacy of soluble CD83 in vitro as well as in vivo

Immunology Letters, 2008
Elisabeth, Zinser, Alexander, Steinkasserer   +1 more
openaire   +2 more sources