Results 151 to 160 of about 10,033 (176)

Porcine CD83 is a glycosylated dimeric protein existing naturally in membrane-bound and soluble forms

Developmental & Comparative Immunology, 2019
Human and mouse CD83 have been well characteized, however, the other mammalian CD83 genes have not been cloned and characterized. In this study, the porcine CD83 (pCD83) was cloned, expressed and characterized, and showed that the pCD83 gene has 81% and 74% homologies with humans and mice, respectively, which was identified to be glycosylated when ...
Shanshan, Huo, Jianlou, Zhang, Fengyang, Wu, Yuzhu, Zuo, Dan, Cui, Xiujin, Li, Zhenyu, Zhong, Fei, Zhong   +7 more
openaire   +4 more sources

Expression of soluble CD83 in plasma from early-stage rheumatoid arthritis patients is not modified by anti-TNF-α therapy

Cytokine, 2017
Rheumatoid arthritis (RA) is an autoimmune disease which may lead to severe disabilities due to structural joint damage and extraarticular manifestations The dendritic cell marker CD83 belongs to the immunoglobulin superfamily and has previously been associated with autoimmune diseases.
Anne-Mette Kristensen, Kristian Stengaard-Pedersen, Merete Lund Hetland, Kim Hørslev-Petersen, Peter Junker, Mikkel Østergaard, Per Höllsberg, Bent Deleuran, Malene Hvid   +8 more
openaire   +7 more sources

Porcine soluble CD83 alleviates LPS-induced abortion in mice by promoting Th2 cytokine production, Treg cell generation and trophoblast invasion

Theriogenology, 2020
CD83, either in its membrance-bound form (mCD83) or soluble form (sCD83), is an important immunomodulatory molecule in humans and mice. While mCD83 is immunostimulatory, sCD83 exhibits striking immunosuppressive activities, suggesting that sCD83 may be used to combat inflammatory diseases, such as rheumatoid arthritis, graft-versus-host disease and ...
Shanshan, Huo, Fengyang, Wu, Jianlou, Zhang, Xing, Wang, Wenyan, Li, Dan, Cui, Yuzhu, Zuo, Man, Hu, Fei, Zhong   +8 more
openaire   +4 more sources

Prevention of Chronic Renal Allograft Rejection by Soluble CD83

Transplantation, 2010
Recombinant human soluble CD83 had previously exhibited significant immunosuppressive properties that involved interference with dendritic cell maturation in both mouse and humans, inhibition of autoimmunity in mice, and induction of antigen-specific mouse cardiac allograft tolerance when used in combination with other immunosuppressive drugs.
Zhu, Lan, Dameng, Lian, Weihua, Liu, Jacqueline, Arp, Brayden, Charlton, Wei, Ge, Stephen, Brand, Don, Healey, Mark, DeBenedette, Charles, Nicolette, Bertha, Garcia, Hao, Wang   +11 more
openaire   +2 more sources

Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses

Immunologic Research, 2020
Aberrant T helper-2 (Th2) responses play a critical role in the pathogenesis of allergic diseases. The underlying mechanism is to be further investigated. It is reported that soluble CD83 (sCD83) has immune-regulatory effects. This study aims to investigate the role of sCD83 in the regulation of Th2 polarization.
Wenyue Song, Hongfen Li, Bingkun Jia, Zhenxi Wang, Qingsheng Liu, Guangping Yang, Xiaorong Li   +6 more
openaire   +2 more sources

Immunosuppression Involving Soluble CD83 Induces Tolerogenic Dendritic Cells That Prevent Cardiac Allograft Rejection

Transplantation, 2010
Dendritic cells (DCs) are crucial regulators of immunity and important in inducing and maintaining tolerance. Here, we investigated the potential of a novel DC-immunomodulating agent, soluble CD83 (sCD83), in inducing transplant tolerance.We used the C3H-to-C57BL/6 mouse cardiac transplantation model that exhibits a combination of severe cell-mediated ...
Wei, Ge, Jacqueline, Arp, Dameng, Lian, Weihua, Liu, Miren L, Baroja, Jifu, Jiang, Siobhan, Ramcharran, Firas Zahr, Eldeen, Elisabeth, Zinser, Alexander, Steinkasserer, Perry, Chou, Stephen, Brand, Charles, Nicolette, Bertha, Garcia, Hao, Wang   +14 more
openaire   +2 more sources

Membrane-bound and soluble porcine CD83 functions antithetically in T cell activation and dendritic cell differentiation in vitro

Developmental & Comparative Immunology, 2019
Emerging evidence suggests that CD83, a dendritic cells (DCs) maturation marker in humans and mice, may prossess immunomodulatory capacities. Although porcine CD83 shares ∼75% sequence homology with its human counterpart, whether it functions as an immunoregulatory molecule remains unknown. To investigate porcine CD83 function, we deleted it in porcine
Shanshan, Huo, Jianlou, Zhang, Shuang, Liang, Fengyang, Wu, Yuzhu, Zuo, Dan, Cui, Yonghong, Zhang, Zhenyu, Zhong, Fei, Zhong   +8 more
openaire   +2 more sources

Production and characterization of human soluble CD83 fused with the fragment crystallizable region of human IgG1 in Pichia pastoris

Applied Microbiology and Biotechnology, 2013
The cell surface protein CD83 belongs to the immunoglobulin superfamily and is highly expressed on mature dendritic cells. The soluble form of CD83, sCD83, is a potential immune suppressor. In a previous study, recombinant soluble CD83 was expressed in Escherichia coli, resulting in a lack of functional glycosylation.
Yuan, Y., Wan, L., Chen, Younan, Shi, M., Wang, C., Zhao, J., Lu, X., Wang, H., Lu, Y., Cheng, J.   +9 more
openaire   +3 more sources

Induction of Kidney Allograft Tolerance by Soluble CD83 Associated With Prevalence of Tolerogenic Dendritic Cells and Indoleamine 2,3-Dioxygenase

Transplantation, 2010
Tolerogenic dendritic cells (Tol-DCs) play a critical role in inducing and maintaining tolerance. Recognizing that both T-cell inactivation and activation are contingent on signals provided by DCs and that graft-specific activated T cells are major mediators of transplant rejection, we aimed to create an environment favoring Tol-DCs with a novel ...
Zhu, Lan, Wei, Ge, Jacqueline, Arp, Jifu, Jiang, Weihua, Liu, Dina, Gordon, Don, Healey, Mark, DeBenedette, Charles, Nicolette, Bertha, Garcia, Hao, Wang   +10 more
openaire   +2 more sources

Levels of the soluble forms of CD80, CD86, and CD83 are elevated in the synovial fluid of rheumatoid arthritis patients

Tissue Antigens, 2005
AbstractThe release of soluble forms of CD80 (sCD80), CD86 (sCD86), and CD83 (sCD83) provide a potentially powerful immunoregulatory mechanism. We therefore investigated the potential presence and relative levels of these molecules in the synovial fluid (SF) and serum of patients with rheumatoid arthritis (RA) and osteoarthritis (OA).
B D, Hock, J L, O'Donnell, K, Taylor, A, Steinkasserer, J L, McKenzie, A G, Rothwell, K L, Summers   +6 more
openaire   +2 more sources