Results 141 to 150 of about 534,042 (160)

Involvement of membrane CD83 / soluble CD83 in autoimmune pemphigus

Implication du couple CD83 membranaire / CD83 soluble dans le pemphigus auto-immun Le pemphigus est un groupe hétérogène de maladies bulleuses auto-immunes intra-épithéliales où les lymphocytes B produisent des auto-anticorps pathogènes directement responsables des lésions bulleuses et érosives, cutanées et muqueuses. Les thérapeutiques
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Membrane-bound and soluble porcine CD83 functions antithetically in T cell activation and dendritic cell differentiation in vitro

Developmental & Comparative Immunology, 2019
Emerging evidence suggests that CD83, a dendritic cells (DCs) maturation marker in humans and mice, may prossess immunomodulatory capacities. Although porcine CD83 shares ∼75% sequence homology with its human counterpart, whether it functions as an immunoregulatory molecule remains unknown. To investigate porcine CD83 function, we deleted it in porcine
Shanshan, Huo, Jianlou, Zhang, Shuang, Liang, Fengyang, Wu, Yuzhu, Zuo, Dan, Cui, Yonghong, Zhang, Zhenyu, Zhong, Fei, Zhong   +8 more
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Induction of Kidney Allograft Tolerance by Soluble CD83 Associated With Prevalence of Tolerogenic Dendritic Cells and Indoleamine 2,3-Dioxygenase

Transplantation, 2010
Tolerogenic dendritic cells (Tol-DCs) play a critical role in inducing and maintaining tolerance. Recognizing that both T-cell inactivation and activation are contingent on signals provided by DCs and that graft-specific activated T cells are major mediators of transplant rejection, we aimed to create an environment favoring Tol-DCs with a novel ...
Zhu, Lan, Wei, Ge, Jacqueline, Arp, Jifu, Jiang, Weihua, Liu, Dina, Gordon, Don, Healey, Mark, DeBenedette, Charles, Nicolette, Bertha, Garcia, Hao, Wang   +10 more
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The anti-inflammatory properties of soluble CD83 in a mouse-model of allergic contact dermatitis

Background and objectives: Allergic contact dermatitis (ACD) is a common inflammatory skin disease with a great socioeconomic impact in industrialized countries. No causal therapy for ACD has been implemented, yet. Based on the pathophysiology, irritant contact dermatitis (ICD) and ACD are distinguished.
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Production of Recombinant Human Soluble CD83 in an Eukaryotic System and Generation of Tissue-Specific CD83 Knock-out Mice

2011
Das glykosylierte Transmembranprotein CD83 mit einer Molekülmasse von 45kDa gehört zur Immunoglobulin-Superfamilie. CD83 wird von Langerhans- und Retikulumzellen, sowie von aktivierten Lymphozyten exprimiert. Darüber hinaus ist CD83 vor allem als eines der besten Oberflächenmarkerproteine auf humanen, reifen dendritischen Zellen (DZ) bekannt.
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Soluble CD83 reverses alopecia areata via indoleamine 2,3-dioxygenase-mediated regulatory T cell activation

British Journal of Dermatology
Abstract Background The primary cause of alopecia areata (AA) is autoimmune-mediated hair follicle destruction, while breakdown of immune tolerance due to disruption of regulatory T cell (Treg) homeostasis critically contributes to this process.
Sheng Wan, Yujie Li, Xu Liu, Xiuzu Song
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Published studies reporting the efficacy of soluble CD83 in vitro as well as in vivo

Immunology Letters, 2008
Elisabeth, Zinser, Alexander, Steinkasserer   +1 more
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Soluble CD83 reverses alopecia areata via IDO-mediated Treg cell activation.

The British journal of dermatology
The primary cause of alopecia areata (AA) is autoimmune-mediated hair follicle destruction, while breakdown of immune tolerance due to Treg cell homeostasis disruption critically contributes to this process. However, in AA, the factors leading to Treg cell impairment and the effective regulatory pathways remain unanswered.To assess the therapeutic ...
Sheng, Wan, Yujie, Li, Xu, Liu, Xiuzu, Song   +3 more
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SUPPRESSION OF ANTIDONOR ANTIBODY RESPONSE BY SOLUBLE CD83 PREVENTS CHRONIC RENAL ALLOGRAFT REJECTION

Transplantation Journal, 2010
Z. Lan, W. Ge, J. Arp, W. Liu, S. Brand, D. Healey, C. Nicolette, B. Garcia, H. Wang   +8 more
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Therapeutic activity of soluble CD83: Comments on Pashine et al.

Immunology Letters, 2008
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