Results 131 to 140 of about 534,042 (160)

The Soluble Form of CD83 Is Present at Elevated Levels in a Number of Hematological Malignancies

Leukemia Research, 2004
Recombinant forms of soluble CD83 (sCD83) inhibit anti-tumor responses. In this analysis of circulating sCD83 levels we report that although >95% of acute myeloid leukemia (AML) and multiple myeloma (MM) patients have normal or only weakly elevated sCD83 levels, 20% of chronic lymphocytic leukemia (CLL) and 5/7 mantle cell lymphoma (MCL) patients have ...
Alexander Steinkasserer, Barry Hock, Karen G Taylor   +2 more
exaly   +3 more sources

Release and Clinical Significance of Soluble CD83 in Chronic Lymphocytic Leukemia

Leukemia Research, 2009
Soluble CD83 (sCD83), a potent immunosuppressive agent, circulates at elevated levels in some chronic lymphocytic leukemia (CLL) patients. We report that CLL patients with elevated plasma sCD83 levels had significantly shorter (P=0.038) treatment free survival.
Alexander Steinkasserer, Andrew Cox, J L McKenzie   +2 more
exaly   +3 more sources

Soluble CD83 Inhibits Human Monocyte Differentiation Into Dendritic Cells in Vitro

Cellular Immunology, 2014
Human CD83 is type I transmembrane glycoprotein, mainly expressed on mature dendritic cells (DCs), so it was first described as a molecular marker for mature DC. However, increasing evidence has demonstrated that CD83 is also an immunomodulatory molecule either its membrane-bound CD83 (mCD83) or soluble CD83 (sCD83) released from DCs. Intriguingly, the
Shuang Liang, Xiujin Li, Zhenyu Zhong
exaly   +3 more sources

Porcine CD83 Is a Glycosylated Dimeric Protein Existing Naturally in Membrane-Bound and Soluble Forms

Developmental and Comparative Immunology, 2019
Human and mouse CD83 have been well characteized, however, the other mammalian CD83 genes have not been cloned and characterized. In this study, the porcine CD83 (pCD83) was cloned, expressed and characterized, and showed that the pCD83 gene has 81% and 74% homologies with humans and mice, respectively, which was identified to be glycosylated when ...
Xiujin Li, Yuzhu Zuo, Fei Zhong
exaly   +3 more sources

Increased Levels of Circulating Soluble CD14 but Not CD83 in Infants Are Associated With Early Intestinal Colonization With Staphylococcus aureus

Clinical and Experimental Allergy, 2007
BACKGROUND: Soluble forms of the monocyte marker CD14 and the mature dendritic cell marker CD83 are plasma proteins with immunoregulatory functions. The physiological stimulus for their production is unclear and their possible role in allergy development
Alexander Steinkasserer, Agnes Wold, Anna-Carin Lundell   +2 more
exaly   +1 more source

Prevention of Chronic Renal Allograft Rejection by Soluble CD83

Transplantation, 2010
Recombinant human soluble CD83 had previously exhibited significant immunosuppressive properties that involved interference with dendritic cell maturation in both mouse and humans, inhibition of autoimmunity in mice, and induction of antigen-specific mouse cardiac allograft tolerance when used in combination with other immunosuppressive drugs.
Zhu, Lan, Dameng, Lian, Weihua, Liu, Jacqueline, Arp, Brayden, Charlton, Wei, Ge, Stephen, Brand, Don, Healey, Mark, DeBenedette, Charles, Nicolette, Bertha, Garcia, Hao, Wang   +11 more
openaire   +2 more sources

Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses

Immunologic Research, 2020
Aberrant T helper-2 (Th2) responses play a critical role in the pathogenesis of allergic diseases. The underlying mechanism is to be further investigated. It is reported that soluble CD83 (sCD83) has immune-regulatory effects. This study aims to investigate the role of sCD83 in the regulation of Th2 polarization.
Wenyue Song, Hongfen Li, Bingkun Jia, Zhenxi Wang, Qingsheng Liu, Guangping Yang, Xiaorong Li   +6 more
openaire   +2 more sources

Immunosuppression Involving Soluble CD83 Induces Tolerogenic Dendritic Cells That Prevent Cardiac Allograft Rejection

Transplantation, 2010
Dendritic cells (DCs) are crucial regulators of immunity and important in inducing and maintaining tolerance. Here, we investigated the potential of a novel DC-immunomodulating agent, soluble CD83 (sCD83), in inducing transplant tolerance.We used the C3H-to-C57BL/6 mouse cardiac transplantation model that exhibits a combination of severe cell-mediated ...
Wei, Ge, Jacqueline, Arp, Dameng, Lian, Weihua, Liu, Miren L, Baroja, Jifu, Jiang, Siobhan, Ramcharran, Firas Zahr, Eldeen, Elisabeth, Zinser, Alexander, Steinkasserer, Perry, Chou, Stephen, Brand, Charles, Nicolette, Bertha, Garcia, Hao, Wang   +14 more
openaire   +2 more sources

Levels of the soluble forms of CD80, CD86, and CD83 are elevated in the synovial fluid of rheumatoid arthritis patients

Tissue Antigens, 2005
AbstractThe release of soluble forms of CD80 (sCD80), CD86 (sCD86), and CD83 (sCD83) provide a potentially powerful immunoregulatory mechanism. We therefore investigated the potential presence and relative levels of these molecules in the synovial fluid (SF) and serum of patients with rheumatoid arthritis (RA) and osteoarthritis (OA).
B D, Hock, J L, O'Donnell, K, Taylor, A, Steinkasserer, J L, McKenzie, A G, Rothwell, K L, Summers   +6 more
openaire   +2 more sources

Increased levels of circulating soluble CD14 but not CD83 in infants are associated with early intestinal colonization with Staphylococcus aureus

Clinical & Experimental Allergy, 2006
SummaryBackground Soluble forms of the monocyte marker CD14 and the mature dendritic cell marker CD83 are plasma proteins with immunoregulatory functions. The physiological stimulus for their production is unclear and their possible role in allergy development is unknown.Methods We measured the plasma levels of soluble CD14 (sCD14) and ...
A-C, Lundell, I, Adlerberth, E, Lindberg, H, Karlsson, S, Ekberg, N, Aberg, R, Saalman, B, Hock, A, Steinkasserer, B, Hesselmar, A E, Wold, A, Rudin   +11 more
openaire   +2 more sources