Properties of epoxide hydrolase from the yeast Rhodotorula glutinis [PDF]
Epoxide hydrolases are ubiquitous enzymes that can be found in nearly all living organisms. Some of the enzymes play an important role in detoxifying xenobiotic and metabolic compounds.
Ariës-Kronenburg, N.A.E.
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Molecules, 2015 Selaginellin derivatives 1–3 isolated from Selaginella tamariscina were evaluated for their inhibition of soluble epoxide hydrolase (sEH) to demonstrate their potential for the treatment of cardiovascular disease.
Jang Hoon Kim +6 more
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Oxylipins in triglyceride-rich lipoproteins of dyslipidemic subjects promote endothelial inflammation following a high fat meal. [PDF]
, 2019 Elevated triglyceride-rich lipoproteins (TGRL) in circulation is a risk factor for atherosclerosis. TGRL from subjects consuming a high saturated fat test meal elicited a variable inflammatory response in TNFα-stimulated endothelial cells (EC) that ...
Akre, Samir +6 more
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The pseudomonas aeruginosa secreted protein PA2934 decreases apical membrane expression of the cystic fibrosis transmembrane conductance regulator [PDF]
, 2007 We previously reported that Pseudomonas aeruginosa PA14 secretes a protein that can reduce the apical membrane expression of the cystic fibrosis transmembrane conductance regulator (CFTR) protein.
Bomberger, Jennifer M. +6 more
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Mammalian epoxide hydrolases in xenobiotic metabolism and signalling [PDF]
, 2018 Epoxide hydrolases catalyse the hydrolysis of electrophilic—and therefore potentially genotoxic—epoxides to the corresponding less reactive vicinal diols, which explains the classification of epoxide hydrolases as typical detoxifying enzymes.
Arand, Michael +2 more
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Soluble Epoxide Hydrolase as a Therapeutic Target for Neuropsychiatric Disorders [PDF]
, 2022 Jiajing Shan, Kenji Hashimoto
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Deletion of soluble epoxide hydrolase attenuates mice Hyperoxic acute lung injury
BMC Anesthesiology, 2018 Background Recent studies reported that soluble epoxide hydrolase (sEH) plays an important role in lung diseases. However, the role of sEH in hyperoxia-induced ALI is unclear.
Li-Ping Liu +4 more
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Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis. [PDF]
, 2017 Epoxides are highly useful synthons and biosynthons for the construction of complex natural products during total synthesis and biosynthesis, respectively.
Garcia-Borràs, Marc +8 more
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Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson’s Disease: A New Therapeutic Strategy [PDF]
, 2020 Mercè Pallàs +4 more
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Frontiers in Pharmacology, 2019 Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to cardiotoxicity.
Victor Samokhvalov +9 more
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