Soluble guanylate cyclase induces cranial vasodilation and headache in adults:a randomized trial. [PDF]
Brain CommunThe role of cranial vasodilation in headache pathogenesis sparks ongoing debate. Soluble guanylate cyclase is an enzyme that catalyses the conversion of guanosine triphosphate to cyclic guanosine monophosphate, leading to relaxation of vascular smooth ...
Ashina, Håkan +7 more
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The nitric oxide–soluble guanylate cyclase–cGMP pathway in pulmonary hypertension: from PDE5 to soluble guanylate cyclase [PDF]
European Respiratory ReviewThe nitric oxide (NO)–soluble guanylate cyclase (sGC)–cyclic guanosine monophosphate (cGMP) pathway plays a key role in the pathogenesis of pulmonary hypertension (PH).
Raymond L. Benza +4 more
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Analysis of research trends and development prospects of soluble guanylate cyclase stimulators/activators: using bibliometric methods [PDF]
Frontiers in PharmacologyBackgroundThe stimulation and activation of soluble guanylate cyclase (sGC) has been a prominent focus of study in recent years. Currently, sGC stimulators/activators have a wide range of applications in various fields.
Bing Ju Yan +3 more
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Efficacy and safety of soluble guanylate cyclase stimulators or activators for chronic kidney disease: a systematic review and meta-analysis [PDF]
Frontiers in MedicineBackgroundChronic Kidney Disease (CKD) poses a major global health burden, leading to serious complications and death. The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signaling axis regulates various kidney ...
Jiaying Zhang, Xin Li, Xiaofeng Yu
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Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia and associated LUTS [PDF]
Continence, 2023 This review summarises the presentations during a workshop session entitled “The Use of Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia, Obstruction and Fibrosis – Mechanistic Concepts and Clinical Implications” at the ...
A.J. Kanai +3 more
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Activation mechanism of human soluble guanylate cyclase by stimulators and activators [PDF]
Nature Communications, 2021 Soluble guanylate cyclase (sGC) is a validated drug target for cardiovascular diseases. Here, the authors report structures of human sGC in complex with NO and sGC stimulators or activator, providing insight into the mechanism of sGC activation by ...
Rui Liu, Yunlu Kang, Lei Chen
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Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP [PDF]
The Journal of Clinical Investigation, 2023 Red blood cells (RBCs) mediate cardioprotection via nitric oxide–like bioactivity, but the signaling and the identity of any mediator released by the RBCs remains unknown.
Jiangning Yang +16 more
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A Phase II study of avenciguat, a novel soluble guanylate cyclase activator, in patients with systemic sclerosis: Study design and rationale of the VITALISScE™ study [PDF]
J Scleroderma Relat DisordINTRODUCTION Systemic sclerosis is a rare autoimmune connective tissue disease characterised by (1) microvasculopathy; (2) immune dysregulation; and (3) progressive fibrosis of the skin and internal organs. Soluble guanylate cyclase plays an important
de Vries-Bouwstra, Jeska +9 more
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Phase 1 Study of MK-5475, an Inhaled Soluble Guanylate Cyclase Stimulator, in Participants with Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease [PDF]
Int J Chron Obstruct Pulmon DisEdnan K Bajwa,1 Dawn Cislak,1 Amit Kumar,1 Dan Li,1 Eric J Messina,1 Tom Reynders,2 Jean-François Denef,2 Vasile Corcea,3 Ketan P Buch,4 Eseng Lai,1 S Aubrey Stoch1 1MRL, Merck & Co., Inc., Rahway, NJ, USA; 2Translational Medicine, MSD Belgium, Brussels,
Corcea V +10 more
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Riociguat: a soluble guanylate cyclase stimulator for the treatment of pulmonary hypertension
Drug Design, Development and Therapy, 2017 Tian-Yu Lian, Xin Jiang, Zhi-Cheng Jing State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic ...
Lian TY, Jiang X, Jing ZC
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