Results 21 to 30 of about 467,321 (167)

The efficacy and safety of soluble guanylate cyclase modulation in patients with heart failure: a comprehensive meta-analysis of randomized controlled trials [PDF]

Scientific Reports
Soluble guanylate cyclase (sGC) modulation has been scrutinized in several disease states including heart failure (HF). Recently, it was shown that an sGC modulator improved HF-related hospitalization significantly, though, there was no benefit related ...
Mehmet Emin Arayici, Hakan Gunes, Hulya Ellidokuz, Mehmet Birhan Yilmaz   +3 more
doaj   +2 more sources

A Zebrafish Drug-Repurposing Screen Reveals sGC-Dependent and sGC-Independent Pro-Inflammatory Activities of Nitric Oxide. [PDF]

PLoS ONE, 2015
Tissue injury and infection trigger innate immune responses. However, dysregulation may result in chronic inflammation and is commonly treated with corticosteroids and non-steroidal anti-inflammatory drugs. Unfortunately, long-term administration of both
Christine Wittmann, Markus Reischl, Asmi H Shah, Eva Kronfuss, Ralf Mikut, Urban Liebel, Clemens Grabher   +6 more
doaj   +1 more source

Vericiguat: A New Hope for Heart Failure Patients

Cardiovascular Therapeutics, 2022
Heart failure with reduced ejection fraction (HFrEF) is the inability of the heart to adequately contract or eject blood. This heart is unable to produce adequate cardiac output to perfuse vital tissues.
Raquel Chiles, Rami A. Al-Horani
doaj   +1 more source

Neurons exposed to ammonia reproduce the differential alteration in nitric oxide modulation of guanylate cyclase in the cerebellum and cortex of patients with liver cirrhosis

Neurobiology of Disease, 2005
The activation of soluble guanylate cyclase by nitric oxide is increased in the frontal cortex but is reduced in the cerebellum of patients who died with liver cirrhosis.
Regina Rodrigo, Slaven Erceg, Vicente Felipo   +2 more
doaj   +1 more source

Multilimbed membrane guanylate cyclase signaling system, evolutionary ladder

Frontiers in Molecular Neuroscience, 2023
One monumental discovery in the field of cell biology is the establishment of the membrane guanylate cyclase signal transduction system. Decoding its fundamental, molecular, biochemical, and genetic features revolutionized the processes of developing ...
Teresa Duda, Rameshwar K. Sharma
doaj   +1 more source

Localization of soluble guanylate cyclase activity in the guinea pig inner ear

, 2000
The aim of this study was to characterize the nitric oxide (NO) receptor soluble guanylate cyclase (sGC), to determine the cells targeted by NO and to elucidate the function of the NO/cGMP pathway in the inner ear.
Popa, Raul,, Takumida, Masaya,, Anniko, Matti,, Zhang, De Ming,   +3 more
core   +8 more sources

Vericiguat: The Fifth Harmony of Heart Failure with Reduced Ejection Fraction

Journal of Cardiovascular Development and Disease, 2023
Heart failure with reduced ejection fraction is a chronic and progressive syndrome that continues to be a substantial financial burden for health systems in Western countries. Despite remarkable advances in pharmacologic and device-based therapy over the
Luigi Falco, Benedetta Brescia, Dario Catapano, Maria Luigia Martucci, Fabio Valente, Rita Gravino, Carla Contaldi, Giuseppe Pacileo, Daniele Masarone   +8 more
doaj   +1 more source

Heterogeneity in human soluble guanylate cyclase due to alternative splicing [PDF]

, 1991
Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase.
Frändberg, Per-Anders, Johan Ahlner, Per-Anders Frändberg, Chhajlani, Vijay, Ahlner, Johan, Vijay Chhajlani, Axelsson, Krister L., Krister L. Axelsson, Jarl E.S. Wikberg, Wikberg, Jarl E.S.   +9 more
core   +1 more source

Repurposing Riociguat for Treatment of Refractory Angina Resulting From Coronary Spasm

JACC: Case Reports, 2021
Coronary spasm is a frequent cause of angina despite unobstructed coronary arteries, and symptom control with recommended drugs is limited. We report the case of a 77-year-old woman who had refractory angina despite conventional antianginal treatment ...
Valeria Martínez Pereyra, MS, Andreas Seitz, MD, Astrid Hubert, PhD, Sascha Beck, MS, Ute Hofmann, PhD, Matthias Schwab, MD, Raffi Bekeredjian, MD, Udo Sechtem, MD, Peter Ong, MD   +8 more
doaj   +1 more source

cGMP becomes a drug target [PDF]

, 2012
Cyclic guanosine 3',5'-monophosphate (cGMP) serves as a second messenger molecule, which regulates pleiotropic cellular functions in health and disease.
Schlossmann, Jens, Jens Schlossmann, Elisabeth Schinner, Schinner, E.   +3 more
core   +2 more sources