Results 31 to 40 of about 467,321 (167)

Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer

Nature Communications, 2021
The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (CDX ...
Maximilian W. Schenk, Sam Humphrey, A. S. Md Mukarram Hossain, Mitchell Revill, Sarah Pearsall, Alice Lallo, Stewart Brown, Samuel Bratt, Melanie Galvin, Tine Descamps, Cong Zhou, Simon P. Pearce, Lynsey Priest, Michelle Greenhalgh, Anshuman Chaturvedi, Alastair Kerr, Fiona Blackhall, Caroline Dive, Kristopher K. Frese   +18 more
doaj   +1 more source

Inhaled nitric oxide decreases pulmonary soluble guanylate cyclase protein levels in 1-month-old lambs [PDF]

, 2004
BackgroundInhaled nitric oxide produces potent pulmonary vasodilation by activating soluble guanylate cyclase and increasing smooth muscle cell concentrations of cyclic guanosine monophosphate.
Johengen, Michael J, Ovadia, Boaz, Thelitz, Stephan, Fineman, Jeffrey R, Bekker, Janine M, Black, Stephen M, Stuart, Regan B   +6 more
core   +1 more source

Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation

Pteridines, 2013
Tetrahydrobiopterin (BH4) is a major endogenous vasoprotective agent that improves endothelial function by increasing nitric oxide (NO) synthesis and scavenging of superoxide and peroxynitrite.
Schmidt Kurt, Werner Ernst R., Mayer Bernd   +2 more
doaj   +1 more source

Increased protein phosphatase 5 expression in inflammation-induced left ventricular dysfunction in rats

BMC Cardiovascular Disorders, 2022
Background Titin phosphorylation contributes to left ventricular (LV) diastolic dysfunction. The independent effects of inflammation on the molecular pathways that regulate titin phosphorylation are unclear.
Ashmeetha Manilall, Lebogang Mokotedi, Sulè Gunter, Regina Le Roux, Serena Fourie, Colleen A. Flanagan, Aletta M. E. Millen   +6 more
doaj   +1 more source

The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclase [PDF]

, 1988
The primary structure of the 70 kDa subunit of soluble bovine guanylate cyclase, which catalyzes the formation of cyclic GMP from GTP, has been determined. The alignment of six different clones out of two bovine libraries yielded a total of 3.1 kb with a
Herz, Joachim, Niroomand, Feraydoon, Eycke Böhme, Klaus-Dieter Hinsch, Gausepohl, Heinrich, Günter Schultz, Doris Koesling, Rainer Frank, Mülsch, Alexander, Feraydoon Niroomand, Heinrich Gausepohl, Frank, Rainer, Schultz, Günter, Koesling, Doris, Böhme, Eycke, Alexander Mülsch, Joachim Herz, Hinsch, Klaus-Dieter   +17 more
core   +1 more source

Crystal structures of the catalytic domain of human soluble guanylate cyclase.

PLoS ONE, 2013
Soluble guanylate cyclase (sGC) catalyses the synthesis of cyclic GMP in response to nitric oxide. The enzyme is a heterodimer of homologous α and β subunits, each of which is composed of multiple domains.
Charles K Allerston, Frank von Delft, Opher Gileadi   +2 more
doaj   +1 more source

Adenosine prevents TNFα-induced decrease in endothelial mitochondrial mass via activation of eNOS-PGC-1α regulatory axis. [PDF]

PLoS ONE, 2014
We tested whether adenosine, a cytoprotective mediator and trigger of preconditioning, could protect endothelial cells from inflammation-induced deficits in mitochondrial biogenesis and function.
Theodore J Kalogeris, Christopher Baines, Ronald J Korthuis   +2 more
doaj   +1 more source

YC-1, a Nitric Oxide-Independent Activator of Soluble Guanylate Cyclase, Inhibits the Spontaneous Contractions of Isolated Pregnant Rat Myometrium

Journal of Pharmacological Sciences, 2004
The aim of this study was to investigate the effect of YC-1 (3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole) on spontaneous contractions and levels of cyclic GMP (cGMP) of myometrial strips isolated from pregnant rats.
Ali Cetin, Tijen Kaya, Nihal Demirkoprulu, Baris Karadas, Bulent Duran, Meral Cetin   +5 more
doaj   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Cyclic GMP in the pig vitreous and retina after experimental retinal detachment [PDF]

, 2008
Purpose: Earlier studies have revealed a decreased level of cGMP in vitreous fluid obtained from patients with a retinal detachment. To further investigate this phenomenon, we developed an experimental retinal detachment model in pigs.
Heij, E.C., La, La Heij, Ellen C, Diederen, R., Diederen, Roselie M H, Lemmens, Marijke A M, de Vente, Jan, De Vente, J., La Heij, E.C., Lemmens, M.A.M., Kijlstra, Aize, Vente, J., De, Hendrikse, F., Hendrikse, Fred, Kijlstra, A.   +13 more
core