Results 191 to 200 of about 134,028 (256)

A multiplex interactome of Ebola virus proteins reveals TM9SF2 as a cell‐surface attachment factor that promotes viral entry

iMetaOmics, EarlyView.
This study generates a comprehensive Ebola virus (EBOV)‐human protein–protein interactome, comprising 1728 core high‐confidence interactions. Further interactome analysis revealed the potential association of EBOV glycoprotein (GP) with the host factor TM9SF2. Subsequent mechanistic investigations confirmed that TM9SF2 functions as an attachment factor
Limin Shang, Shouwen Du, Yuchen Liu, Letian Li, Xi Wu, Yanzhi Yuan, Chaozhi Jin, Qingkun Mi, Yuhang Wang, Xiaoshuang Shi, Jiamin Wang, Guoqing Zhang, Yidan Ma, Weijin Huang, Jigang Wang, Jian Wang, Chang Li   +16 more
wiley   +1 more source

The Role of Proinflammatory Cytokines in Temporomandibular Disorders: A Systematic Review. [PDF]

Int J Mol Sci
Grzech-Leśniak Z, Matuszewska A, Fiegler-Rudol J, El Mobadder M, Wiench R, Więckiewicz M.   +5 more
europepmc   +1 more source

The gut microbiome organ

iMeta, EarlyView.
The gut microbiome can be conceptualized as a distributed organ‐like functional system with spatially structured organization, broad biochemical capacity, and continuous bidirectional communication with the host. By transforming dietary, host‐derived, and environmental substrates into bioactive metabolites with endocrine‐like, immunomodulatory, and ...
Yang Bi, Weibin Song, Maria Glymenaki, Jie Hu, Xiru Li, Heng Huang, Yousong Peng, Shuaishuai Ni, Ornuma Haonon, Zhu Liu, Krai Daowtak, Xiaotao Shen, Huadong Peng, Jutarop Phetcharaburanin, Huiru Tang, Yulan Wang, Jia V. Li, Mizu Jiang, Nick Powell, Victor W. Zhong, Elaine Holmes, Yunlei Xianyu, Zhigang Liu   +22 more
wiley   +1 more source

sCD126 as An Independent Prognostic Biomarker in Critical COVID-19. [PDF]

J Innate Immun
Marinakis G, Karakike E, Koufargyris P, Patrani M, Giamarellos-Bourboulis EJ.   +4 more
europepmc   +1 more source

Hyperoside alleviates endometrial stromal cell senescence in unexplained recurrent spontaneous abortion via DHX9‐mediated R‐loop resolution

iMeta, EarlyView.
This study suggests that the food‐derived flavonoid hyperoside may act as a natural DExH‐box helicase 9 (DHX9) modulator, directly targeting Thr419 of DHX9 to help resolve pathological R‐loop accumulation. Consequently, it suppresses cyclic GMP‐AMP synthase‐stimulator of interferon genes (cGAS‐STING)‐driven endometrial stromal senescence and restores ...
Yuepeng Jiang, Hongli Zhao, Xinyi Ding, Haoling Zhang, Yadong Guo, Yiming Ma, Lingyi Cai, Qingnan Fan, Ruisi Peng, Fuyuan Yang, Doblin Sandai, Xianling Cao, Jiali Yao, Wenyi Wang, Zhiheng Lin, Wangzheqi Zhang, Jialin He, Aihua Zhang, Xiaoxuan Zhao   +18 more
wiley   +1 more source

Targeting the MICA/B-NKG2D axis in cancer: from molecular structure to immunotherapeutic strategies-a narrative review. [PDF]

Transl Cancer Res
Zheng Y, Ding W, Chen B, Geng C, Li X.
europepmc   +1 more source

Methodological Insights Into T-Cell Activation: CD3/CD28 Versus PMA/Ionomycin Stimulation. [PDF]

Eur J Immunol
Abdulhaqov N, Melo LTA, Meinert I, Fricke S, Simeoni L.   +4 more
europepmc   +1 more source

Coombs-Negative Hemolytic Anemia and Thrombocytopenia Associated With Sarcoidosis Confined to the Spleen and Bone Marrow: A Case Report. [PDF]

Cureus
Uemura Y, Togitani K, Nakashima J.
europepmc   +1 more source

A human cerebral organoid model of West Nile virus encephalitis shows innate immunocompetency. [PDF]

Nat Commun
Steffen JF, Widerspick L, Jansen S, Tappe D.   +3 more
europepmc   +1 more source