Results 51 to 60 of about 433,346 (276)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

THE EVALUATION OF FRUITS QUALITY IN SOME STRAWBERRY CULTIVARS (FRAGARIA X ANANASSA L. DUCH.) [PDF]

Fruit Growing Research, 2015
The major factors influencing the strawberries quality are the genotype, culture technology, climatic conditions and harvest time. In Romania consumers like strawberry fruits especially picked in May to June season, in that period having better ...
Sturzeanu Monica, Ancu Irina, Chitu Emil
doaj  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Morpho-agronomic and organoleptic response of five banana cultivars (Musa spp.) under field conditions

Biotecnología Vegetal, 2020
In Cuba, banana production is destined for the national market as fresh fruit and plays an essential role in food security. The objective of this work was to evaluate in field conditions the morpho-agronomic and organoleptic characteristics of five ...
Daily Torres-Cabrera, Leyanes García-Águila, Idalmis Bermúdez-Caraballoso, Zoe Sarría, Ortelio Hurtado Ribalta, Enmanuel Delgado, Amado Pérez, Osvaldo Fernández Martínez   +7 more
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Inheritance of Soluble Solids and Pyruvic Acid Content of Bulb Onions [PDF]

Journal of the American Society for Horticultural Science, 1995
Analysis of parents and progeny generations of bulb onion (Allium cepa L.) crosses among parents with differing content of soluble solids (SS) and pyruvic acid (PA) showed that SS and PA are expressed and inherited in a quantitative manner.
Mau-Wei Lin, James F. Watson, James R. Baggett   +2 more
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Postharvest Quality of ‘Keepsake’ Apple Fruit

HortTechnology
Storage information regarding ‘Keepsake’ apple fruit is lacking. The objective of this research was to investigate the postharvest characteristics of ‘Keepsake’ apple (Malus ×domestica Borkh.), which is a parent of ‘Honeycrisp’. Apples were obtained from
Cindy Tong
doaj   +1 more source

Flow behavior and physicochemical characterization of peach pulps

Scientia Agropecuaria, 2012
Rheological and physicochemical analyses were conducted on nine varieties of peach pulps from Mendoza (Argentina) at a range of soluble solids concentration (12.5 to 28°Brix) and temperatures (30 to 50°C).The rheology of the pulps followed the power ...
Ernesto Muñoz Puntes, Luis A. Rubio, María S. Cabeza   +2 more
doaj   +1 more source