Results 151 to 160 of about 1,044,480 (214)

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, Volume 7, Issue 5, October 2026.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Targeted protein degradation dismantles undruggable targets to reverse immune evasion and therapy resistance in cancer. [PDF]

Front Immunol
Zhang F, Wang Q, Li M, Wang T, Lei P, Huang T, Wu Z.   +6 more
europepmc   +1 more source

Dapagliflozin Attenuates NKCC2 Protein Expression and Alleviates Diabetic Kidney Disease in Salt Loaded‐Hypertensive Diabetic Db/Db Mice

FASEB BioAdvances, Volume 8, Issue 10, October 2026.
In salt‐loaded, hypertensive diabetic db/db mice with diabetic kidney disease, dapagliflozin lowered blood pressure and reduced tubular and glomerular injury. Mechanistically, dapagliflozin increased cullin E3 ligase abundance, promoting degradation of NKCC2.
Zenab Shahzad, Niharika Bala, Arooba Illyas, Amir Kazory, Indra Chandrasekar, Abdel A. Alli   +5 more
wiley   +1 more source

Polypropylene Nanoplastic Exposure to Respiratory Epithelial Barrier‐On‐Chip and Interfacial Interactions With Human Serum Albumin

Allergy, Volume 81, Issue 10, Page 3488-3503, October 2026.
Exposure to 305 nm PP NPs significantly disrupts the airway barrier‐on‐chip, reducing TEER, suppressing ZO‐1/ACE2 expression, and triggering ROS‐mediated apoptosis. In biological media, PP NPs exhibit a biphasic adsorption pattern, leading to the formation of a protein corona that increases their size to 364 nm.
Omur Sert, Eyup Bilgi, Reyhan Coban, Pelin Saglam‐Metiner, Basar Dogan, Zeynep Imir‐Tekneci, Suleyman Selim Cinaroglu, Ozlem Goksel, Ceyda Oksel Karakus, Ozlem Yesil‐Celiktas   +9 more
wiley   +1 more source

Altered iron metabolism and iron therapy in restless legs syndrome. [PDF]

J Neural Transm (Vienna)
Wei Z, Earley CJ.
europepmc   +1 more source

Iron, Biofilm, and Colorectal Cancer: Mechanistic Insights Into Enterococcus faecalis Pathogenesis

APMIS, Volume 134, Issue 10, October 2026.
ABSTRACT Enterococcus faecalis is a commensal of the human gastrointestinal microbiota that has emerged as a successful opportunistic pathogen associated with persistent infections, antimicrobial resistance, and biofilm formation. Increasing evidence indicates that iron availability functions as a master environmental signal coordinating E.
Sibusiso Luthuli, Nathalie Scarpulla, Lorenzo Bertolino, Lulama Luthuli, Emanuele Durante‐Mangoni   +4 more
wiley   +1 more source

High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance

Cell Proliferation, Volume 59, Issue 10, October 2026.
In hyperuricemia, uric acid inhibits CCDC90B ubiquitination degradation by binding to it. Excessive CCDC90B induces mitochondrial calcium overload, leading to mitochondrial quality control imbalance and ultimately resulting in SLC senescence and decreased testosterone levels.
Jiayu Huang, Ao Wang, Xiangyu Li, Peng Huang, Kaixuan Zeng, Lu Sun, Moxuan Li, Yixiang Chen, Jiancheng Wang   +8 more
wiley   +1 more source

African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children. [PDF]

Nat Commun
Muriuki JM, Mentzer AJ, Band G, Chong AY, Macharia AW, Mogire RM, Abuga KM, Mitchell R, Gilchrist JJ, Webb EL, Ndungu FM, Raffield LM, Ekunwe L, Bentley AR, Sirima SB, Madhi SA, Hill AVS, Prentice AM, Bejon P, Hemani G, Smith GD, Sandhu MS, Elliott AM, Williams TN, Adeyemo A, Atkinson SH.   +25 more
europepmc   +1 more source

Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia

European Journal of Haematology, Volume 117, Issue 4, Page 728-738, October 2026.
ABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
João Vitor Facco, Diane S. Krause, Sara T. Olalla Saad   +2 more
wiley   +1 more source

Biomarker-Defined Iron Deficiency in Heavy Smokers with and without COPD and/or Emphysema. [PDF]

Int J Chron Obstruct Pulmon Dis
Hardang IM, Neumann K, Gjønnes GT, Strand TE, Ashraf H, Einvik G.   +5 more
europepmc   +1 more source