This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang +10 more
wiley +1 more source
Dysregulated Iron Homeostasis in Atopic Dermatitis: Linking Iron Deficiency to Clinical Severity and Quality of Life. [PDF]
Ponikowska M +2 more
europepmc +1 more source
Iron Status, Erythropoietin, and Cancer Incidence in the General Population
This study investigated the association between iron parameters and EPO and the development of overall and site‐specific cancer in a large cohort with a median follow‐up of 18.5 years (n = 6109; 1090 de novo malignancies). In multivariable cox proportional hazard analysis, we found that increased EPO, and decreased hepcidin concentrations are ...
Siem J. van Alfen +10 more
wiley +1 more source
Maternal Adiposity and DNA Methylation of TfR2 and HJV Genes in Early Pregnancy: Mediating Role of Inflammation and Consequences for Iron Status. [PDF]
Demirdjian SP +9 more
europepmc +1 more source
Abstract Erythropoietin (EPO) administration stimulates haematological and non‐haematological adaptations that alter substrate oxidation and enhance aerobic performance. The effects of strenuous exercise and EPO on metabolites, and whether any effect is associated with haematological and non‐haematological adaptations, has not been assessed.
Devin J. Drummer +11 more
wiley +1 more source
TMPRSS11E-mediated TFR1 cleavage influences IFN-γR2 internalization and the macrophage innate response. [PDF]
Wang T +10 more
europepmc +1 more source
The development of effective strategies for the detoxification of organophosphorus (OP) nerve agents has evolved from the early mechanistic studies of François Terrier and collaborators, who first elucidated the exceptional nucleophilicity of α‐effect species such as oximes and hydroxamates, to the modern design of supramolecular and material‐based ...
Pedro Rodríguez‐Dafonte
wiley +1 more source
New insights in nanocrystal technology chemotherapeutic drugs targeting cancer with a translational research paradigm. [PDF]
Iqbal FM +7 more
europepmc +1 more source
Some aspects of the anemia of chronic disorders modeled and analyzed by petri net based approach [PDF]
Dorota Formanowicz +4 more
core +1 more source
Assessment of Hepcidin-25 and Iron Status Profiles in Pregnant Women With Thalassemia Minor. [PDF]
Jiampochaman T +6 more
europepmc +1 more source

