Results 241 to 250 of about 5,368,005 (298)
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Somatic Stem Cells in the Endometrium
Reproductive Sciences, 2009The human endometrium has cycles of growth, differentiation, and regeneration. In that respect, the concept that endometrial stem cells are responsible for the regenerative capacity of this tissue was proposed many years ago. Recently, the cells that present features of somatic stem cells have been identified in murine and human endometria where the ...
Cervello, I, Simon, C
openaire +3 more sources
Malignancy of Somatic Cell Hybrids
Nature, 1969HARRIS et al.1 have observed the suppression of the malignancy of three types of malignant cell as a result of their fusion with cells of line A9, which they considered non-malignant. Here we supplement their data with information neglected by or unavailable to them.
B, Ephrussi +4 more
openaire +2 more sources
Interaction of Sperm with Somatic Cells
Science, 1974We regret we did not cite the earlier work of our colleagues in the field of gynecology mentioned above; we disagree with their contention that the methods were put to the same use and achieved the same results. Our study dealt with nonphagocytic spermatozoal transfer of genetic information to cultured somatic cells. Coppleson and Reid regarded sperm
M, Coppleson, B L, Reid
openaire +2 more sources
Reprogramming of Somatic Cells
2012Reprogramming of adult somatic cells into pluripotent stem cells may provide an attractive source of stem cells for regenerative medicine. It has emerged as an invaluable method for generating patient-specific stem cells of any cell lineage without the use of embryonic stem cells.
openaire +2 more sources
Somatic evolution of cancer cells
Seminars in Cancer Biology, 2005Cancers develop through a process called genomic instability, which generates diversity, from which clonal evolution may occur. In colorectal cancers, this process has been extensively studied, and there are three identifiable processes involved in generating diversity at the genetic or epigenetic level.
C Richard, Boland, Ajay, Goel
openaire +2 more sources
Reprogramming of Somatic Cells to Pluripotency
2010Reprogramming of somatic cells into pluripotent stem cells has been achieved by introducing four transcription factors, Sox2, Oct3/4, Klf4 and c-Myc, in 2006. These induced pluripotent stem (iPS) cells have raised hopes for a new era of regenerative medicine because they can avoid the ethical problems and innate immune rejection associated with ...
Masato, Nakagawa, Shinya, Yamanaka
openaire +2 more sources
Embryonic and somatic cell cloning
Reproduction, Fertility and Development, 1999Revolutionary opportunities in biology, medicine and agriculture arise from the observation that offspring are obtained after nuclear transfer if somatic donor cells are induced to become quiescent. Exploitation of many of these opportunities will depend upon optimizing procedures for nuclear transfer.
I, Wilmut, L, Young, K H, Campbell
openaire +2 more sources