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Reprogramming mammalian somatic cells
Theriogenology, 2012Somatic cell nuclear transfer (SCNT), the technique commonly known as cloning, permits transformation of a somatic cell into an undifferentiated zygote with the potential to develop into a newborn animal (i.e., a clone). In somatic cells, chromatin is programmed to repress most genes and express some, depending on the tissue.
N, Rodriguez-Osorio +4 more
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Construction of Somatic Cell Hybrids
Current Protocols in Human Genetics, 1996AbstractSomatic cell hybridization is the method of choice to separate a chromosome of interest from the full chromosome complement and obtain a permanent source of the chromosome. This unit begins with the choice of fusion techniques and selectable markers for hybrids containing a chromosome of interest.
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Transformationlike Phenomena in Somatic Cells
1968Publisher Summary This chapter explains how to reproduce transformation phenomena by the action of exogenous DNA on somatic cells have been confronted with a number of difficulties, some of which are hardly foreseen. The additional complications arose in connection with the appearance of transformationlike phenomena in experiments with RNA as the ...
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Reprogramming of somatic cells: iPS and iN cells.
Progress in brain research, 2017Limited access to human neurons has posed a significant barrier to progress in biological and preclinical studies of the human nervous system. The advent of cell reprogramming technologies has widely disclosed unprecedented opportunities to generate renewable sources of human neural cells for disease modeling, drug discovery, and cell therapeutics ...
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A tribute to somatic cell reprogrammers
MHR: Basic science of reproductive medicine, 2012For many biologists, the ‘holy grail’ has been to derive pluripotent cells that have the potential to differentiate into all cell types of the body. They represent enormous scientific value as they can be used to study differentiation, the onset of disease and, in the long term, offer a significant therapeutic potential (Colman and Dreesen, 2009). Long
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Telomerase expression in somatic cells
The Lancet, 2005Eric M, Brey, Howard P, Greisler
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